{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:JPFGUIXRWJCJ2LPMOOLAEFUDSD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bef65dbcb92d8b15f12932d3284a78a2c2a74adba102ee0d3cfb06740526f975","cross_cats_sorted":["cs.AI"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CE","submitted_at":"2024-12-04T16:14:02Z","title_canon_sha256":"dc229714a5738b0e3206240898a66f669a4c91d4fd1dcdcce3cbc92946fef309"},"schema_version":"1.0","source":{"id":"2412.03424","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2412.03424","created_at":"2026-07-05T09:44:29Z"},{"alias_kind":"arxiv_version","alias_value":"2412.03424v1","created_at":"2026-07-05T09:44:29Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2412.03424","created_at":"2026-07-05T09:44:29Z"},{"alias_kind":"pith_short_12","alias_value":"JPFGUIXRWJCJ","created_at":"2026-07-05T09:44:29Z"},{"alias_kind":"pith_short_16","alias_value":"JPFGUIXRWJCJ2LPM","created_at":"2026-07-05T09:44:29Z"},{"alias_kind":"pith_short_8","alias_value":"JPFGUIXR","created_at":"2026-07-05T09:44:29Z"}],"graph_snapshots":[{"event_id":"sha256:ca22071b5a4fa9ac6a905f3bb5cafabcde190dd3ac32459f2ae8b735ab4f8655","target":"graph","created_at":"2026-07-05T09:44:29Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2412.03424/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Computer-aided synthesis planning (CASP) has made significant strides in generating retrosynthetic pathways for simple molecules in a non-constrained fashion. Recent work introduces a specialised bidirectional search algorithm with forward and retro expansion to address the starting material-constrained synthesis problem, allowing CASP systems to provide synthesis pathways from specified starting materials, such as waste products or renewable feed-stocks. In this work, we introduce a simple guided search which allows solving the starting material-constrained synthesis planning problem using an","authors_text":"Daniel Armstrong, Jeff Guo, Philippe Schwaller, Zlatko Joncev","cross_cats":["cs.AI"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CE","submitted_at":"2024-12-04T16:14:02Z","title":"Tango*: Constrained synthesis planning using chemically informed value functions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.03424","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:405dd72e358536b7d480a53cc45527b276c844ef2d374ebbb655dd88b407710a","target":"record","created_at":"2026-07-05T09:44:29Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bef65dbcb92d8b15f12932d3284a78a2c2a74adba102ee0d3cfb06740526f975","cross_cats_sorted":["cs.AI"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.CE","submitted_at":"2024-12-04T16:14:02Z","title_canon_sha256":"dc229714a5738b0e3206240898a66f669a4c91d4fd1dcdcce3cbc92946fef309"},"schema_version":"1.0","source":{"id":"2412.03424","kind":"arxiv","version":1}},"canonical_sha256":"4bca6a22f1b2449d2dec739602168390c8a7348423c06df02020987c70dc1483","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4bca6a22f1b2449d2dec739602168390c8a7348423c06df02020987c70dc1483","first_computed_at":"2026-07-05T09:44:29.233233Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:44:29.233233Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"1gpR+cDXw0gi22fha0LfujWGnNF9Y99ClbYb77opuYrYASuw/n92tkZwqbZjhguUhaXHxL20P3boeQ5D5GnqDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T09:44:29.233709Z","signed_message":"canonical_sha256_bytes"},"source_id":"2412.03424","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:405dd72e358536b7d480a53cc45527b276c844ef2d374ebbb655dd88b407710a","sha256:ca22071b5a4fa9ac6a905f3bb5cafabcde190dd3ac32459f2ae8b735ab4f8655"],"state_sha256":"321a85b31d55292d3d773d9d5aff7c28c4442b0d9016ccf2ac7578fae12fe89e"}