{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:JRPOTBG2YRTDRFDFRV2WJPZGCP","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c02d3a5151ad20b7e24b9fb14af58323f24b5c3aaaa7f4d4fe4aa47bfe001a2a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2022-07-16T21:08:39Z","title_canon_sha256":"06853b6a4b73d64f6b9550832aae4c2f054b922a385d74ea3ffb702709bfbbea"},"schema_version":"1.0","source":{"id":"2207.08016","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2207.08016","created_at":"2026-07-05T10:02:39Z"},{"alias_kind":"arxiv_version","alias_value":"2207.08016v1","created_at":"2026-07-05T10:02:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2207.08016","created_at":"2026-07-05T10:02:39Z"},{"alias_kind":"pith_short_12","alias_value":"JRPOTBG2YRTD","created_at":"2026-07-05T10:02:39Z"},{"alias_kind":"pith_short_16","alias_value":"JRPOTBG2YRTDRFDF","created_at":"2026-07-05T10:02:39Z"},{"alias_kind":"pith_short_8","alias_value":"JRPOTBG2","created_at":"2026-07-05T10:02:39Z"}],"graph_snapshots":[{"event_id":"sha256:524816c530f6f4427c17285a0c7cc2e8b8ab0cc49d0f71d2cd251ab9b5866ebf","target":"graph","created_at":"2026-07-05T10:02:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2207.08016/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Purpose: Patient-specific ridge filters can modulate proton energy to obtain a conformal dose. We describe a new framework for optimization of filter design and spot maps to meet the unique demands of FLASH radiotherapy. We demonstrate an Integrated Biological Optimization IMPT (IBO-IMPT) approach for optimization of dose, dose-averaged dose rate (DADR), and dose-averaged LET (LETd). Methods: We developed inverse planning software to design patient-specific ridge filters that spread the Bragg peak from a fixed-energy, 250 MeV beam to a proximal beam-specific planning target volume. The softwar","authors_text":"Filipa Baltazar, Jeffrey Bradley, Jun Zhou, Kristin Higgins, Liyong Lin, Martina Palkowitsch, Minglei Kang, Niklas Wahl, Ruirui Liu, Serdar Charyyev, Wei Liu, William Dynan, Xiaofeng Yang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2022-07-16T21:08:39Z","title":"An Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2207.08016","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:98ed053ee919a041c49cbb09a7a6c9dfec2e4d04a19a01fd0d21b51393e970f2","target":"record","created_at":"2026-07-05T10:02:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c02d3a5151ad20b7e24b9fb14af58323f24b5c3aaaa7f4d4fe4aa47bfe001a2a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2022-07-16T21:08:39Z","title_canon_sha256":"06853b6a4b73d64f6b9550832aae4c2f054b922a385d74ea3ffb702709bfbbea"},"schema_version":"1.0","source":{"id":"2207.08016","kind":"arxiv","version":1}},"canonical_sha256":"4c5ee984dac4663894658d7564bf2613cbb510f70e07545ea6582e71a0798121","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4c5ee984dac4663894658d7564bf2613cbb510f70e07545ea6582e71a0798121","first_computed_at":"2026-07-05T10:02:39.400515Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:02:39.400515Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Cs0fPhM/fwsuAqDLIwIvypefypyN9CjZurPG3dW/YfmQW/7R0rT9bakrOPSiN+AUBAVNWZRao0mzR8qCWmoxAw==","signature_status":"signed_v1","signed_at":"2026-07-05T10:02:39.401013Z","signed_message":"canonical_sha256_bytes"},"source_id":"2207.08016","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:98ed053ee919a041c49cbb09a7a6c9dfec2e4d04a19a01fd0d21b51393e970f2","sha256:524816c530f6f4427c17285a0c7cc2e8b8ab0cc49d0f71d2cd251ab9b5866ebf"],"state_sha256":"70b0c51a52a086cfe759195894c63341f4a57b55cf2cf8cee8c3553602e9f888"}