{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:JSSJK3OUAB5VHB7GPQZU7XU6W7","short_pith_number":"pith:JSSJK3OU","canonical_record":{"source":{"id":"1011.5747","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2010-11-26T10:25:06Z","cross_cats_sorted":["stat.TH"],"title_canon_sha256":"8b3151a0c707ab4c4188420ed3d22724249aadbf5739336f1bf5fa9ae6d47ef2","abstract_canon_sha256":"2129a8d40f819ee4695950f64760232a151ff613b6e22dd821e91426b9f6ec23"},"schema_version":"1.0"},"canonical_sha256":"4ca4956dd4007b5387e67c334fde9eb7e2abcb6b730b040afe79955b6b314070","source":{"kind":"arxiv","id":"1011.5747","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1011.5747","created_at":"2026-05-18T04:34:38Z"},{"alias_kind":"arxiv_version","alias_value":"1011.5747v1","created_at":"2026-05-18T04:34:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1011.5747","created_at":"2026-05-18T04:34:38Z"},{"alias_kind":"pith_short_12","alias_value":"JSSJK3OUAB5V","created_at":"2026-05-18T12:26:09Z"},{"alias_kind":"pith_short_16","alias_value":"JSSJK3OUAB5VHB7G","created_at":"2026-05-18T12:26:09Z"},{"alias_kind":"pith_short_8","alias_value":"JSSJK3OU","created_at":"2026-05-18T12:26:09Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:JSSJK3OUAB5VHB7GPQZU7XU6W7","target":"record","payload":{"canonical_record":{"source":{"id":"1011.5747","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2010-11-26T10:25:06Z","cross_cats_sorted":["stat.TH"],"title_canon_sha256":"8b3151a0c707ab4c4188420ed3d22724249aadbf5739336f1bf5fa9ae6d47ef2","abstract_canon_sha256":"2129a8d40f819ee4695950f64760232a151ff613b6e22dd821e91426b9f6ec23"},"schema_version":"1.0"},"canonical_sha256":"4ca4956dd4007b5387e67c334fde9eb7e2abcb6b730b040afe79955b6b314070","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:34:38.540665Z","signature_b64":"5taiJr574DSLUR58vbyusZjoS236nMaUL9O1rsmJ5A1kEKRW98crssJxuqVzDKw0GJtcMp6IxuenpjPWGmGVCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4ca4956dd4007b5387e67c334fde9eb7e2abcb6b730b040afe79955b6b314070","last_reissued_at":"2026-05-18T04:34:38.540183Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:34:38.540183Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1011.5747","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:34:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"33nSQPO90ht67Hlyryv56niDczNAlCGQL3c0UZGESUTFguGPPa9fXt3Tyu9lID76hskXscd6e9KT2lBoIDSxCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T17:55:21.196188Z"},"content_sha256":"85e3a52184de71403d0204846dde74fd4a0a2ebf3d2424938da5fe8124bf7a88","schema_version":"1.0","event_id":"sha256:85e3a52184de71403d0204846dde74fd4a0a2ebf3d2424938da5fe8124bf7a88"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:JSSJK3OUAB5VHB7GPQZU7XU6W7","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Optimal designs for discriminating between dose-response models in toxicology studies","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.TH"],"primary_cat":"math.ST","authors_text":"Andrey Pepelyshev, Holger Dette, Piter Shpilev, Weng Kee Wong","submitted_at":"2010-11-26T10:25:06Z","abstract_excerpt":"We consider design issues for toxicology studies when we have a continuous response and the true mean response is only known to be a member of a class of nested models. This class of non-linear models was proposed by toxicologists who were concerned only with estimation problems. We develop robust and efficient designs for model discrimination and for estimating parameters in the selected model at the same time. In particular, we propose designs that maximize the minimum of $D$- or $D_1$-efficiencies over all models in the given class. We show that our optimal designs are efficient for determi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1011.5747","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:34:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"q1cFwWwxyjMpuu9v0oKnZdv9fv0bDoJhjysiPTZ0VqAgbbHZEhXdENl3TNmebw3OcE07v255iQiNFjn7OnbGCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T17:55:21.196788Z"},"content_sha256":"0e392b2f6f0cdbf14c5c95a917715378b3a3933e6fe8d31612068bfc48529441","schema_version":"1.0","event_id":"sha256:0e392b2f6f0cdbf14c5c95a917715378b3a3933e6fe8d31612068bfc48529441"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/JSSJK3OUAB5VHB7GPQZU7XU6W7/bundle.json","state_url":"https://pith.science/pith/JSSJK3OUAB5VHB7GPQZU7XU6W7/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/JSSJK3OUAB5VHB7GPQZU7XU6W7/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-20T17:55:21Z","links":{"resolver":"https://pith.science/pith/JSSJK3OUAB5VHB7GPQZU7XU6W7","bundle":"https://pith.science/pith/JSSJK3OUAB5VHB7GPQZU7XU6W7/bundle.json","state":"https://pith.science/pith/JSSJK3OUAB5VHB7GPQZU7XU6W7/state.json","well_known_bundle":"https://pith.science/.well-known/pith/JSSJK3OUAB5VHB7GPQZU7XU6W7/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:JSSJK3OUAB5VHB7GPQZU7XU6W7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2129a8d40f819ee4695950f64760232a151ff613b6e22dd821e91426b9f6ec23","cross_cats_sorted":["stat.TH"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2010-11-26T10:25:06Z","title_canon_sha256":"8b3151a0c707ab4c4188420ed3d22724249aadbf5739336f1bf5fa9ae6d47ef2"},"schema_version":"1.0","source":{"id":"1011.5747","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1011.5747","created_at":"2026-05-18T04:34:38Z"},{"alias_kind":"arxiv_version","alias_value":"1011.5747v1","created_at":"2026-05-18T04:34:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1011.5747","created_at":"2026-05-18T04:34:38Z"},{"alias_kind":"pith_short_12","alias_value":"JSSJK3OUAB5V","created_at":"2026-05-18T12:26:09Z"},{"alias_kind":"pith_short_16","alias_value":"JSSJK3OUAB5VHB7G","created_at":"2026-05-18T12:26:09Z"},{"alias_kind":"pith_short_8","alias_value":"JSSJK3OU","created_at":"2026-05-18T12:26:09Z"}],"graph_snapshots":[{"event_id":"sha256:0e392b2f6f0cdbf14c5c95a917715378b3a3933e6fe8d31612068bfc48529441","target":"graph","created_at":"2026-05-18T04:34:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We consider design issues for toxicology studies when we have a continuous response and the true mean response is only known to be a member of a class of nested models. This class of non-linear models was proposed by toxicologists who were concerned only with estimation problems. We develop robust and efficient designs for model discrimination and for estimating parameters in the selected model at the same time. In particular, we propose designs that maximize the minimum of $D$- or $D_1$-efficiencies over all models in the given class. We show that our optimal designs are efficient for determi","authors_text":"Andrey Pepelyshev, Holger Dette, Piter Shpilev, Weng Kee Wong","cross_cats":["stat.TH"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2010-11-26T10:25:06Z","title":"Optimal designs for discriminating between dose-response models in toxicology studies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1011.5747","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:85e3a52184de71403d0204846dde74fd4a0a2ebf3d2424938da5fe8124bf7a88","target":"record","created_at":"2026-05-18T04:34:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2129a8d40f819ee4695950f64760232a151ff613b6e22dd821e91426b9f6ec23","cross_cats_sorted":["stat.TH"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.ST","submitted_at":"2010-11-26T10:25:06Z","title_canon_sha256":"8b3151a0c707ab4c4188420ed3d22724249aadbf5739336f1bf5fa9ae6d47ef2"},"schema_version":"1.0","source":{"id":"1011.5747","kind":"arxiv","version":1}},"canonical_sha256":"4ca4956dd4007b5387e67c334fde9eb7e2abcb6b730b040afe79955b6b314070","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4ca4956dd4007b5387e67c334fde9eb7e2abcb6b730b040afe79955b6b314070","first_computed_at":"2026-05-18T04:34:38.540183Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:34:38.540183Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"5taiJr574DSLUR58vbyusZjoS236nMaUL9O1rsmJ5A1kEKRW98crssJxuqVzDKw0GJtcMp6IxuenpjPWGmGVCA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:34:38.540665Z","signed_message":"canonical_sha256_bytes"},"source_id":"1011.5747","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:85e3a52184de71403d0204846dde74fd4a0a2ebf3d2424938da5fe8124bf7a88","sha256:0e392b2f6f0cdbf14c5c95a917715378b3a3933e6fe8d31612068bfc48529441"],"state_sha256":"8a4ba9b9ba09eaf7012184b2b9f942bdbef463980f0f776a6e460dab1d4d7ac7"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"qUzBOC77xZ8h96MLK1N9F45EaHEQYCMUzm+sCYWRzKN4hEI4YdD3E/4UV1W4PtB3Krp7IzUnHpk9hEAepr0kAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-20T17:55:21.198866Z","bundle_sha256":"87bfd068c0f566b6b6ad8a5006b09c3bd8304dd28639883a9cd79549be0597c2"}}