{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:KBGI2HBM5XPWITXFCESMYTZWEE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"16efdd066afdd99463693e15b15d84e4f755992f46235b10a7e89443e8001d00","cross_cats_sorted":["cs.AI"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.BM","submitted_at":"2025-07-03T06:13:23Z","title_canon_sha256":"b760f7fa01c121c89727fb6c5a4c3abdc6ae278deb1e5a143f416fdf2af027bc"},"schema_version":"1.0","source":{"id":"2507.02345","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2507.02345","created_at":"2026-07-05T11:31:16Z"},{"alias_kind":"arxiv_version","alias_value":"2507.02345v1","created_at":"2026-07-05T11:31:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2507.02345","created_at":"2026-07-05T11:31:16Z"},{"alias_kind":"pith_short_12","alias_value":"KBGI2HBM5XPW","created_at":"2026-07-05T11:31:16Z"},{"alias_kind":"pith_short_16","alias_value":"KBGI2HBM5XPWITXF","created_at":"2026-07-05T11:31:16Z"},{"alias_kind":"pith_short_8","alias_value":"KBGI2HBM","created_at":"2026-07-05T11:31:16Z"}],"graph_snapshots":[{"event_id":"sha256:f24cafa223a0e0a2f003bfd4aeb7ea23cb0a380262efc037e3690b40bfb976be","target":"graph","created_at":"2026-07-05T11:31:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2507.02345/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Antibody engineering is essential for developing therapeutics and advancing biomedical research. Traditional discovery methods often rely on time-consuming and resource-intensive experimental screening. To enhance and streamline this process, we introduce a production-grade, high-throughput platform built on HelixFold3, HelixDesign-Antibody, which utilizes the high-accuracy structure prediction model, HelixFold3. The platform facilitates the large-scale generation of antibody candidate sequences and evaluates their interaction with antigens. Integrated high-performance computing (HPC) support ","authors_text":"Jie Gao, Jing Hu, Kunrui Zhu, Shanzhuo Zhang, Sheng Qian, Xiaomin Fang, Xiaonan Zhang, Yueyang Huang","cross_cats":["cs.AI"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.BM","submitted_at":"2025-07-03T06:13:23Z","title":"HelixDesign-Antibody: A Scalable Production-Grade Platform for Antibody Design Built on HelixFold3"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2507.02345","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:850c51332536bb91900a9f9cf81ae43836e46098743dd4425b6e5ef666cf3140","target":"record","created_at":"2026-07-05T11:31:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"16efdd066afdd99463693e15b15d84e4f755992f46235b10a7e89443e8001d00","cross_cats_sorted":["cs.AI"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.BM","submitted_at":"2025-07-03T06:13:23Z","title_canon_sha256":"b760f7fa01c121c89727fb6c5a4c3abdc6ae278deb1e5a143f416fdf2af027bc"},"schema_version":"1.0","source":{"id":"2507.02345","kind":"arxiv","version":1}},"canonical_sha256":"504c8d1c2ceddf644ee51124cc4f36212ed9a66bddf3652478c4b993fed01182","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"504c8d1c2ceddf644ee51124cc4f36212ed9a66bddf3652478c4b993fed01182","first_computed_at":"2026-07-05T11:31:16.346210Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:31:16.346210Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"eTRrUpZIH5VrCFoZQF6eJD/hUO64I5aLhr3ZvH2YDdnQNxJcPM63XPClQyuxckyWBJ/HbrXKEKMo0INC86KZDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T11:31:16.346756Z","signed_message":"canonical_sha256_bytes"},"source_id":"2507.02345","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:850c51332536bb91900a9f9cf81ae43836e46098743dd4425b6e5ef666cf3140","sha256:f24cafa223a0e0a2f003bfd4aeb7ea23cb0a380262efc037e3690b40bfb976be"],"state_sha256":"a443e85252591bcaffd1b013bb0c57fb18aa62cfc66eb86f40b64e76e4ed2276"}