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Asymmetric cryptography methods such as the widely used RSA method allow secure exchange of information between parties who have not shared secret keys. However, the existing asymmetric cryptographic schemes rely on unproven mathematical assumptions for security. Further, the digital keys used in their implementation are susceptible to copying that might remain unnoticed. Here we introduce a secure communication method that overcomes these two limitations by employing Physical Unclonable Keys (PUKs). 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