{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2018:KBYKHF53S534W42QCIIDKEH6RK","short_pith_number":"pith:KBYKHF53","schema_version":"1.0","canonical_sha256":"5070a397bb9777cb735012103510fe8ab7d9587b0176e9f4cc8c2592497fa2b9","source":{"kind":"arxiv","id":"1802.09265","version":2},"attestation_state":"computed","paper":{"title":"Limited Resources Induce Bistability in Microtubule Length Regulation","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"Aniruddha Mitra, Erwin Frey, Louis Reese, Matthias Rank, Stefan Diez","submitted_at":"2018-02-26T12:10:59Z","abstract_excerpt":"The availability of protein is an important factor for the determination of the size of the mitotic spindle. Involved in spindle-size regulation is kinesin-8, a molecular motor and microtubule (MT) depolymerase, which is known to tightly control MT length. Here, we propose and analyze a theoretical model in which kinesin-induced MT depolymerization competes with spontaneous polymerization while supplies of both tubulin and kinesin are limited. In contrast to previous studies where resources were unconstrained, we find that, for a wide range of concentrations, MT length regulation is bistable. "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1802.09265","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-26T12:10:59Z","cross_cats_sorted":["q-bio.SC"],"title_canon_sha256":"019d9850b47e6cdb81d4b18a61361e825936a5ab99396dcfa1257dc4979a6820","abstract_canon_sha256":"6d0f9d8511e4dd6695abf8c145eead484c77d898523d6d7329c196843cab5351"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:19:02.280749Z","signature_b64":"HkCzAAYsc5vJw7lOlCSJGxeijIktLJGxifUrzmqtYy8uwQV2tNtyj5FLoW8PuhoPP/43iVrciU+Qf/xsvC5cAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5070a397bb9777cb735012103510fe8ab7d9587b0176e9f4cc8c2592497fa2b9","last_reissued_at":"2026-05-18T00:19:02.280077Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:19:02.280077Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Limited Resources Induce Bistability in Microtubule Length Regulation","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"Aniruddha Mitra, Erwin Frey, Louis Reese, Matthias Rank, Stefan Diez","submitted_at":"2018-02-26T12:10:59Z","abstract_excerpt":"The availability of protein is an important factor for the determination of the size of the mitotic spindle. Involved in spindle-size regulation is kinesin-8, a molecular motor and microtubule (MT) depolymerase, which is known to tightly control MT length. Here, we propose and analyze a theoretical model in which kinesin-induced MT depolymerization competes with spontaneous polymerization while supplies of both tubulin and kinesin are limited. In contrast to previous studies where resources were unconstrained, we find that, for a wide range of concentrations, MT length regulation is bistable. "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1802.09265","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1802.09265","created_at":"2026-05-18T00:19:02.280189+00:00"},{"alias_kind":"arxiv_version","alias_value":"1802.09265v2","created_at":"2026-05-18T00:19:02.280189+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1802.09265","created_at":"2026-05-18T00:19:02.280189+00:00"},{"alias_kind":"pith_short_12","alias_value":"KBYKHF53S534","created_at":"2026-05-18T12:32:33.847187+00:00"},{"alias_kind":"pith_short_16","alias_value":"KBYKHF53S534W42Q","created_at":"2026-05-18T12:32:33.847187+00:00"},{"alias_kind":"pith_short_8","alias_value":"KBYKHF53","created_at":"2026-05-18T12:32:33.847187+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK","json":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK.json","graph_json":"https://pith.science/api/pith-number/KBYKHF53S534W42QCIIDKEH6RK/graph.json","events_json":"https://pith.science/api/pith-number/KBYKHF53S534W42QCIIDKEH6RK/events.json","paper":"https://pith.science/paper/KBYKHF53"},"agent_actions":{"view_html":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK","download_json":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK.json","view_paper":"https://pith.science/paper/KBYKHF53","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1802.09265&json=true","fetch_graph":"https://pith.science/api/pith-number/KBYKHF53S534W42QCIIDKEH6RK/graph.json","fetch_events":"https://pith.science/api/pith-number/KBYKHF53S534W42QCIIDKEH6RK/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK/action/timestamp_anchor","attest_storage":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK/action/storage_attestation","attest_author":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK/action/author_attestation","sign_citation":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK/action/citation_signature","submit_replication":"https://pith.science/pith/KBYKHF53S534W42QCIIDKEH6RK/action/replication_record"}},"created_at":"2026-05-18T00:19:02.280189+00:00","updated_at":"2026-05-18T00:19:02.280189+00:00"}