{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:KC547HVD3LNOLLK2QORRAM4OAS","short_pith_number":"pith:KC547HVD","canonical_record":{"source":{"id":"2412.05108","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"math.ST","submitted_at":"2024-12-06T15:09:17Z","cross_cats_sorted":["stat.ME","stat.ML","stat.TH"],"title_canon_sha256":"64286828b428ff41e3f29fc8252823e999c682ee75362b3fe30886d29233806c","abstract_canon_sha256":"254f8f6119159b97f1862d144245d502c42fe170b3e05aebeb52bf10a962847c"},"schema_version":"1.0"},"canonical_sha256":"50bbcf9ea3dadae5ad5a83a310338e04bf0993b9119347ba5ca09e9ea186f90d","source":{"kind":"arxiv","id":"2412.05108","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2412.05108","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"arxiv_version","alias_value":"2412.05108v1","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2412.05108","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"pith_short_12","alias_value":"KC547HVD3LNO","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"pith_short_16","alias_value":"KC547HVD3LNOLLK2","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"pith_short_8","alias_value":"KC547HVD","created_at":"2026-07-05T09:45:28Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:KC547HVD3LNOLLK2QORRAM4OAS","target":"record","payload":{"canonical_record":{"source":{"id":"2412.05108","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"math.ST","submitted_at":"2024-12-06T15:09:17Z","cross_cats_sorted":["stat.ME","stat.ML","stat.TH"],"title_canon_sha256":"64286828b428ff41e3f29fc8252823e999c682ee75362b3fe30886d29233806c","abstract_canon_sha256":"254f8f6119159b97f1862d144245d502c42fe170b3e05aebeb52bf10a962847c"},"schema_version":"1.0"},"canonical_sha256":"50bbcf9ea3dadae5ad5a83a310338e04bf0993b9119347ba5ca09e9ea186f90d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:45:28.566043Z","signature_b64":"c+mW9gUpq6cBhQu9DqibCRYNC2BJLalpSe/8GMkNoIWd+jGRDqsCLzMB8Z3xY/PhVi7C1cxS8dYXw1PPaJ9aCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"50bbcf9ea3dadae5ad5a83a310338e04bf0993b9119347ba5ca09e9ea186f90d","last_reissued_at":"2026-07-05T09:45:28.565543Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:45:28.565543Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2412.05108","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:45:28Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9Npy4S8pj6QeHE3MmHfvxTqVSuJE/A1vhRqRb/h0QLOM36HeMUCER4myNuwYmr0ys5uo+x787cS1On+3GUhHDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T16:12:57.449074Z"},"content_sha256":"929a5d6d057197b7cf7acf3be5b3daaee433d41503655d33b387d28c7087b126","schema_version":"1.0","event_id":"sha256:929a5d6d057197b7cf7acf3be5b3daaee433d41503655d33b387d28c7087b126"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:KC547HVD3LNOLLK2QORRAM4OAS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Constructing optimal treatment length strategies to maximize quality-adjusted lifetimes","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["stat.ME","stat.ML","stat.TH"],"primary_cat":"math.ST","authors_text":"Ashkan Ertefaie, Brent A. Johnson, Hao Sun, Luke Duttweiler","submitted_at":"2024-12-06T15:09:17Z","abstract_excerpt":"Real-world clinical decision making is a complex process that involves balancing the risks and benefits of treatments. Quality-adjusted lifetime is a composite outcome that combines patient quantity and quality of life, making it an attractive outcome in clinical research. We propose methods for constructing optimal treatment length strategies to maximize this outcome. Existing methods for estimating optimal treatment strategies for survival outcomes cannot be applied to a quality-adjusted lifetime due to induced informative censoring. We propose a weighted estimating equation that adjusts for"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.05108","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2412.05108/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:45:28Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"neG0UK3hZEQJ8z8eDnA+wJtA9HNvqoHLLcX86D7iPDLPp/h3DrB7bOSZHiiGIHbxDFVeChK0IL2ry0YnnV12Cw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T16:12:57.449574Z"},"content_sha256":"82576277fc4ef8d634c850aca0ac147c2e592de78719ea81a665e77db4c1c71a","schema_version":"1.0","event_id":"sha256:82576277fc4ef8d634c850aca0ac147c2e592de78719ea81a665e77db4c1c71a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/KC547HVD3LNOLLK2QORRAM4OAS/bundle.json","state_url":"https://pith.science/pith/KC547HVD3LNOLLK2QORRAM4OAS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/KC547HVD3LNOLLK2QORRAM4OAS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-07T16:12:57Z","links":{"resolver":"https://pith.science/pith/KC547HVD3LNOLLK2QORRAM4OAS","bundle":"https://pith.science/pith/KC547HVD3LNOLLK2QORRAM4OAS/bundle.json","state":"https://pith.science/pith/KC547HVD3LNOLLK2QORRAM4OAS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/KC547HVD3LNOLLK2QORRAM4OAS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:KC547HVD3LNOLLK2QORRAM4OAS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"254f8f6119159b97f1862d144245d502c42fe170b3e05aebeb52bf10a962847c","cross_cats_sorted":["stat.ME","stat.ML","stat.TH"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"math.ST","submitted_at":"2024-12-06T15:09:17Z","title_canon_sha256":"64286828b428ff41e3f29fc8252823e999c682ee75362b3fe30886d29233806c"},"schema_version":"1.0","source":{"id":"2412.05108","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2412.05108","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"arxiv_version","alias_value":"2412.05108v1","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2412.05108","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"pith_short_12","alias_value":"KC547HVD3LNO","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"pith_short_16","alias_value":"KC547HVD3LNOLLK2","created_at":"2026-07-05T09:45:28Z"},{"alias_kind":"pith_short_8","alias_value":"KC547HVD","created_at":"2026-07-05T09:45:28Z"}],"graph_snapshots":[{"event_id":"sha256:82576277fc4ef8d634c850aca0ac147c2e592de78719ea81a665e77db4c1c71a","target":"graph","created_at":"2026-07-05T09:45:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2412.05108/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Real-world clinical decision making is a complex process that involves balancing the risks and benefits of treatments. Quality-adjusted lifetime is a composite outcome that combines patient quantity and quality of life, making it an attractive outcome in clinical research. We propose methods for constructing optimal treatment length strategies to maximize this outcome. Existing methods for estimating optimal treatment strategies for survival outcomes cannot be applied to a quality-adjusted lifetime due to induced informative censoring. We propose a weighted estimating equation that adjusts for","authors_text":"Ashkan Ertefaie, Brent A. Johnson, Hao Sun, Luke Duttweiler","cross_cats":["stat.ME","stat.ML","stat.TH"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"math.ST","submitted_at":"2024-12-06T15:09:17Z","title":"Constructing optimal treatment length strategies to maximize quality-adjusted lifetimes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.05108","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:929a5d6d057197b7cf7acf3be5b3daaee433d41503655d33b387d28c7087b126","target":"record","created_at":"2026-07-05T09:45:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"254f8f6119159b97f1862d144245d502c42fe170b3e05aebeb52bf10a962847c","cross_cats_sorted":["stat.ME","stat.ML","stat.TH"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"math.ST","submitted_at":"2024-12-06T15:09:17Z","title_canon_sha256":"64286828b428ff41e3f29fc8252823e999c682ee75362b3fe30886d29233806c"},"schema_version":"1.0","source":{"id":"2412.05108","kind":"arxiv","version":1}},"canonical_sha256":"50bbcf9ea3dadae5ad5a83a310338e04bf0993b9119347ba5ca09e9ea186f90d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"50bbcf9ea3dadae5ad5a83a310338e04bf0993b9119347ba5ca09e9ea186f90d","first_computed_at":"2026-07-05T09:45:28.565543Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:45:28.565543Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"c+mW9gUpq6cBhQu9DqibCRYNC2BJLalpSe/8GMkNoIWd+jGRDqsCLzMB8Z3xY/PhVi7C1cxS8dYXw1PPaJ9aCg==","signature_status":"signed_v1","signed_at":"2026-07-05T09:45:28.566043Z","signed_message":"canonical_sha256_bytes"},"source_id":"2412.05108","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:929a5d6d057197b7cf7acf3be5b3daaee433d41503655d33b387d28c7087b126","sha256:82576277fc4ef8d634c850aca0ac147c2e592de78719ea81a665e77db4c1c71a"],"state_sha256":"ca810033e0c65b727ba039bb4a6bee5f7bbbdc127ba9611c7b7795d8e64d218c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9dLHbsp9TSzKTjIF+jv/qnO+8M4a7bE+QyVSq1PU3Zb/7VTLtjgelHWvLxzEV9XI89Pv/9+27y8+VBwS6MC5DQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-07T16:12:57.454981Z","bundle_sha256":"79af18b9bbb80e43775a572cf0e46fe10b3c702b6f80867265a4d8c2b49d8bf8"}}