{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:KDAVSFVHPSKKQ2I7Z77VTLGP3X","short_pith_number":"pith:KDAVSFVH","schema_version":"1.0","canonical_sha256":"50c15916a77c94a8691fcfff59accfddd2de78554c42143e45fd3de8d4e99392","source":{"kind":"arxiv","id":"1606.09123","version":1},"attestation_state":"computed","paper":{"title":"Adapting censored regression methods to adjust for the limit of detection in the calibration of diagnostic rules for clinical mass spectrometry proteomic data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Alexia Kakourou, Bart Mertens, Werner Vach","submitted_at":"2016-06-29T14:38:55Z","abstract_excerpt":"Despite the recent advances in mass spectrometry (MS), summarizing and analyzing high-throughput mass-spectrometry data remains a challenging task. This is, on the one hand, due to the complexity of the spectral signal which is measured, and on the other, due to the limit of detection (LOD). The LOD is related to the limitation of instruments in measuring markers at a relatively low level. As a consequence, the outcome data set from the quantification step of proteomic analysis often consists of a reduced list of peaks where any peak intensities below the detection limit threshold are reported"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1606.09123","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-06-29T14:38:55Z","cross_cats_sorted":[],"title_canon_sha256":"546e2ee9c2acb7804b6d1cc475202a6ac9079869feec8ff68dfab2ca5929b1c1","abstract_canon_sha256":"a2a711f6583925a37182d8e7476e207370c5dd8ba7aab79596fb2b553da7816f"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:11:41.700840Z","signature_b64":"2uwEsMDjG8494nUVZW36+p817GLwWpk7vmm5+9yc+DqaFcZBixJprsAHMdROVtFlclVwzixWMm49gMkQPXmxCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"50c15916a77c94a8691fcfff59accfddd2de78554c42143e45fd3de8d4e99392","last_reissued_at":"2026-05-18T01:11:41.700486Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:11:41.700486Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Adapting censored regression methods to adjust for the limit of detection in the calibration of diagnostic rules for clinical mass spectrometry proteomic data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Alexia Kakourou, Bart Mertens, Werner Vach","submitted_at":"2016-06-29T14:38:55Z","abstract_excerpt":"Despite the recent advances in mass spectrometry (MS), summarizing and analyzing high-throughput mass-spectrometry data remains a challenging task. This is, on the one hand, due to the complexity of the spectral signal which is measured, and on the other, due to the limit of detection (LOD). The LOD is related to the limitation of instruments in measuring markers at a relatively low level. As a consequence, the outcome data set from the quantification step of proteomic analysis often consists of a reduced list of peaks where any peak intensities below the detection limit threshold are reported"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1606.09123","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1606.09123","created_at":"2026-05-18T01:11:41.700545+00:00"},{"alias_kind":"arxiv_version","alias_value":"1606.09123v1","created_at":"2026-05-18T01:11:41.700545+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1606.09123","created_at":"2026-05-18T01:11:41.700545+00:00"},{"alias_kind":"pith_short_12","alias_value":"KDAVSFVHPSKK","created_at":"2026-05-18T12:30:25.849896+00:00"},{"alias_kind":"pith_short_16","alias_value":"KDAVSFVHPSKKQ2I7","created_at":"2026-05-18T12:30:25.849896+00:00"},{"alias_kind":"pith_short_8","alias_value":"KDAVSFVH","created_at":"2026-05-18T12:30:25.849896+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X","json":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X.json","graph_json":"https://pith.science/api/pith-number/KDAVSFVHPSKKQ2I7Z77VTLGP3X/graph.json","events_json":"https://pith.science/api/pith-number/KDAVSFVHPSKKQ2I7Z77VTLGP3X/events.json","paper":"https://pith.science/paper/KDAVSFVH"},"agent_actions":{"view_html":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X","download_json":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X.json","view_paper":"https://pith.science/paper/KDAVSFVH","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1606.09123&json=true","fetch_graph":"https://pith.science/api/pith-number/KDAVSFVHPSKKQ2I7Z77VTLGP3X/graph.json","fetch_events":"https://pith.science/api/pith-number/KDAVSFVHPSKKQ2I7Z77VTLGP3X/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X/action/timestamp_anchor","attest_storage":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X/action/storage_attestation","attest_author":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X/action/author_attestation","sign_citation":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X/action/citation_signature","submit_replication":"https://pith.science/pith/KDAVSFVHPSKKQ2I7Z77VTLGP3X/action/replication_record"}},"created_at":"2026-05-18T01:11:41.700545+00:00","updated_at":"2026-05-18T01:11:41.700545+00:00"}