{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:KDVZRWFSSN7LMWEWDGF7NJ24A6","short_pith_number":"pith:KDVZRWFS","canonical_record":{"source":{"id":"2607.17412","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-07-19T21:20:10Z","cross_cats_sorted":[],"title_canon_sha256":"10247d486b0c4de2d83bf5953536d035f71d4dec74617d2eb5498c4607681d15","abstract_canon_sha256":"f1d9f39eb6c55fa760396e98ceeab441a83877ea1c705f440c36ff6f35f9f0a4"},"schema_version":"1.0"},"canonical_sha256":"50eb98d8b2937eb65896198bf6a75c07b8f7910dfaddc33e661e423a67822e2f","source":{"kind":"arxiv","id":"2607.17412","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.17412","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"arxiv_version","alias_value":"2607.17412v1","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.17412","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"pith_short_12","alias_value":"KDVZRWFSSN7L","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"pith_short_16","alias_value":"KDVZRWFSSN7LMWEW","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"pith_short_8","alias_value":"KDVZRWFS","created_at":"2026-07-21T01:21:31Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:KDVZRWFSSN7LMWEWDGF7NJ24A6","target":"record","payload":{"canonical_record":{"source":{"id":"2607.17412","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-07-19T21:20:10Z","cross_cats_sorted":[],"title_canon_sha256":"10247d486b0c4de2d83bf5953536d035f71d4dec74617d2eb5498c4607681d15","abstract_canon_sha256":"f1d9f39eb6c55fa760396e98ceeab441a83877ea1c705f440c36ff6f35f9f0a4"},"schema_version":"1.0"},"canonical_sha256":"50eb98d8b2937eb65896198bf6a75c07b8f7910dfaddc33e661e423a67822e2f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-21T01:21:31.673863Z","signature_b64":"SXUSfRR8+jeD8ANbG3YE0lXhosb5Cmio4w9RjpkMmdkktrVaRCOqCdNb5JjiywAjCzPYnBo/96u/HQrsIYveCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"50eb98d8b2937eb65896198bf6a75c07b8f7910dfaddc33e661e423a67822e2f","last_reissued_at":"2026-07-21T01:21:31.672922Z","signature_status":"signed_v1","first_computed_at":"2026-07-21T01:21:31.672922Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2607.17412","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-21T01:21:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PrF1US/tQbhw/xjiIukAamg65Vbaf4fuQu33ETQsnpRVjU1hqn8XuO9lTWdLbrMGxGknzy9tkCNkbPyYCEPPCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T18:08:54.235760Z"},"content_sha256":"8b24fba43f06cdda8fd82f2f306c62c6888e54ea59266be8fa1ce12f60614444","schema_version":"1.0","event_id":"sha256:8b24fba43f06cdda8fd82f2f306c62c6888e54ea59266be8fa1ce12f60614444"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:KDVZRWFSSN7LMWEWDGF7NJ24A6","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"CORAL: Learning Amyloid Fibril Ligand Docking with Cooperative Binding Rewards","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cs.LG","authors_text":"Bohan Li, J\\\"urgen Schmidhuber, Yasheng Sun, Youqi Tao","submitted_at":"2026-07-19T21:20:10Z","abstract_excerpt":"A hallmark of neurodegenerative diseases such as Alzheimer's and Parkinson's is the aberrant aggregation of proteins into amyloid fibrils, and small molecules that selectively bind to these fibrils hold promise as diagnostics, imaging probes, and therapeutics. Predicting how such ligands bind to fibril targets, however, presents two fundamental challenges. First, resolved co-crystal structures of amyloid-ligand complexes are exceptionally scarce; even with recent advances in cryo-EM only a handful have been structurally characterized, making supervised training of docking models impractical fo"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.17412","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2607.17412/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-21T01:21:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CS6SjwCMVmH5F3nTBl28TFoIqy4MzJNeJ3SDhaQe9lvyKmSkCWCyI5IBnFmU75BN9rgpYHX6yPj7U1rr5ossBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T18:08:54.236283Z"},"content_sha256":"e61a6327de73f82dcd052be63c72688964f07fca26d8b0da14b24e9bb1f97cf5","schema_version":"1.0","event_id":"sha256:e61a6327de73f82dcd052be63c72688964f07fca26d8b0da14b24e9bb1f97cf5"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/KDVZRWFSSN7LMWEWDGF7NJ24A6/bundle.json","state_url":"https://pith.science/pith/KDVZRWFSSN7LMWEWDGF7NJ24A6/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/KDVZRWFSSN7LMWEWDGF7NJ24A6/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-07T18:08:54Z","links":{"resolver":"https://pith.science/pith/KDVZRWFSSN7LMWEWDGF7NJ24A6","bundle":"https://pith.science/pith/KDVZRWFSSN7LMWEWDGF7NJ24A6/bundle.json","state":"https://pith.science/pith/KDVZRWFSSN7LMWEWDGF7NJ24A6/state.json","well_known_bundle":"https://pith.science/.well-known/pith/KDVZRWFSSN7LMWEWDGF7NJ24A6/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:KDVZRWFSSN7LMWEWDGF7NJ24A6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f1d9f39eb6c55fa760396e98ceeab441a83877ea1c705f440c36ff6f35f9f0a4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-07-19T21:20:10Z","title_canon_sha256":"10247d486b0c4de2d83bf5953536d035f71d4dec74617d2eb5498c4607681d15"},"schema_version":"1.0","source":{"id":"2607.17412","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2607.17412","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"arxiv_version","alias_value":"2607.17412v1","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2607.17412","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"pith_short_12","alias_value":"KDVZRWFSSN7L","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"pith_short_16","alias_value":"KDVZRWFSSN7LMWEW","created_at":"2026-07-21T01:21:31Z"},{"alias_kind":"pith_short_8","alias_value":"KDVZRWFS","created_at":"2026-07-21T01:21:31Z"}],"graph_snapshots":[{"event_id":"sha256:e61a6327de73f82dcd052be63c72688964f07fca26d8b0da14b24e9bb1f97cf5","target":"graph","created_at":"2026-07-21T01:21:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2607.17412/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"A hallmark of neurodegenerative diseases such as Alzheimer's and Parkinson's is the aberrant aggregation of proteins into amyloid fibrils, and small molecules that selectively bind to these fibrils hold promise as diagnostics, imaging probes, and therapeutics. Predicting how such ligands bind to fibril targets, however, presents two fundamental challenges. First, resolved co-crystal structures of amyloid-ligand complexes are exceptionally scarce; even with recent advances in cryo-EM only a handful have been structurally characterized, making supervised training of docking models impractical fo","authors_text":"Bohan Li, J\\\"urgen Schmidhuber, Yasheng Sun, Youqi Tao","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-07-19T21:20:10Z","title":"CORAL: Learning Amyloid Fibril Ligand Docking with Cooperative Binding Rewards"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2607.17412","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8b24fba43f06cdda8fd82f2f306c62c6888e54ea59266be8fa1ce12f60614444","target":"record","created_at":"2026-07-21T01:21:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f1d9f39eb6c55fa760396e98ceeab441a83877ea1c705f440c36ff6f35f9f0a4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2026-07-19T21:20:10Z","title_canon_sha256":"10247d486b0c4de2d83bf5953536d035f71d4dec74617d2eb5498c4607681d15"},"schema_version":"1.0","source":{"id":"2607.17412","kind":"arxiv","version":1}},"canonical_sha256":"50eb98d8b2937eb65896198bf6a75c07b8f7910dfaddc33e661e423a67822e2f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"50eb98d8b2937eb65896198bf6a75c07b8f7910dfaddc33e661e423a67822e2f","first_computed_at":"2026-07-21T01:21:31.672922Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-21T01:21:31.672922Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"SXUSfRR8+jeD8ANbG3YE0lXhosb5Cmio4w9RjpkMmdkktrVaRCOqCdNb5JjiywAjCzPYnBo/96u/HQrsIYveCA==","signature_status":"signed_v1","signed_at":"2026-07-21T01:21:31.673863Z","signed_message":"canonical_sha256_bytes"},"source_id":"2607.17412","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8b24fba43f06cdda8fd82f2f306c62c6888e54ea59266be8fa1ce12f60614444","sha256:e61a6327de73f82dcd052be63c72688964f07fca26d8b0da14b24e9bb1f97cf5"],"state_sha256":"e4d75ab1722c5431f0650f9b93e4012bb50e9dfe91958c3f766bc34752c2e842"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"y84zAM+TikuPzybWTROnLOcybjGI6Vj85zxyOoP6oNq2p0lG7HgpMT66mYGgPjwfqMPCWssS1FsQHa+uwBSkDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-07T18:08:54.242374Z","bundle_sha256":"0ef6d89e55dcadd29cc00d5cd3051bdbb0d34f65552aab31e001bc4730d7f5bb"}}