{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:KGQ7KNK5OUPPCLIDAX6OA5GKDJ","short_pith_number":"pith:KGQ7KNK5","canonical_record":{"source":{"id":"2411.01536","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-11-03T11:44:22Z","cross_cats_sorted":[],"title_canon_sha256":"98aeace738995a6fd3e7577c7824b5a0f3972f84d86b257a0c50e992f250d753","abstract_canon_sha256":"70f9f9cc7cf52cd58ce362b896496f4bacf93b95968e56ee135a43c9dfda3811"},"schema_version":"1.0"},"canonical_sha256":"51a1f5355d751ef12d0305fce074ca1a5cd4ba44bd425a5b58052b09a67243df","source":{"kind":"arxiv","id":"2411.01536","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.01536","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"arxiv_version","alias_value":"2411.01536v2","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.01536","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"pith_short_12","alias_value":"KGQ7KNK5OUPP","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"pith_short_16","alias_value":"KGQ7KNK5OUPPCLID","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"pith_short_8","alias_value":"KGQ7KNK5","created_at":"2026-07-05T10:55:25Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:KGQ7KNK5OUPPCLIDAX6OA5GKDJ","target":"record","payload":{"canonical_record":{"source":{"id":"2411.01536","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-11-03T11:44:22Z","cross_cats_sorted":[],"title_canon_sha256":"98aeace738995a6fd3e7577c7824b5a0f3972f84d86b257a0c50e992f250d753","abstract_canon_sha256":"70f9f9cc7cf52cd58ce362b896496f4bacf93b95968e56ee135a43c9dfda3811"},"schema_version":"1.0"},"canonical_sha256":"51a1f5355d751ef12d0305fce074ca1a5cd4ba44bd425a5b58052b09a67243df","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:55:25.578254Z","signature_b64":"8nLWKs+sJp0hL6ubWsHPMJrX+6+p0bEYFKd9moyfLKXiJ+OGVzttDHhjcWkqAujCGyzu++hQEN3xyiZWwsbnBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"51a1f5355d751ef12d0305fce074ca1a5cd4ba44bd425a5b58052b09a67243df","last_reissued_at":"2026-07-05T10:55:25.577740Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:55:25.577740Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2411.01536","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:55:25Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZlCKy5jnFQPCdZ/Kirc1P1FvWj6nWrwA3g6p2jZjMG50YK+NRZ4MtBS2zHe7ylTnmodm8w3kexbRRBexMqPgDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-09T09:04:27.823084Z"},"content_sha256":"21cbc3a0da2471b682cf60d8552f5d5273807401ee4a4ab613761a39dbd97d2f","schema_version":"1.0","event_id":"sha256:21cbc3a0da2471b682cf60d8552f5d5273807401ee4a4ab613761a39dbd97d2f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:KGQ7KNK5OUPPCLIDAX6OA5GKDJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Separation of ionic timescales explains dynamics of cellular volume regulation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Ram M. Adar","submitted_at":"2024-11-03T11:44:22Z","abstract_excerpt":"Living cells actively regulate their volume in response to changes in the extra-cellular environment, such as osmolarity and chemo-attractant concentration. While the basic physical mechanisms of volume regulation are understood from the classic \"pump-leak\" model, it does not provide an explicit expression for the volume during dynamic regulation and can benefit from further insight into the volume dynamics. Here, we propose a simple explanation of volume dynamics in terms of two phases: fast volume adjustment to membrane potential, largely determined by Cl$^-$ leakage, and slow potential adap"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.01536","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2411.01536/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:55:25Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"uNvT74D38aEjNMYIcdF3qumVA3re1NoVzg34RC/ZCMy9q6g3f1lSUgyYcahbvrJUc7ocYVsYJ9Imc3E830cMCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-09T09:04:27.824908Z"},"content_sha256":"0a99e09aca85825397f17a7c5fd0c1534e74a428926de89803463df81d4d5bf3","schema_version":"1.0","event_id":"sha256:0a99e09aca85825397f17a7c5fd0c1534e74a428926de89803463df81d4d5bf3"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/KGQ7KNK5OUPPCLIDAX6OA5GKDJ/bundle.json","state_url":"https://pith.science/pith/KGQ7KNK5OUPPCLIDAX6OA5GKDJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/KGQ7KNK5OUPPCLIDAX6OA5GKDJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-09T09:04:27Z","links":{"resolver":"https://pith.science/pith/KGQ7KNK5OUPPCLIDAX6OA5GKDJ","bundle":"https://pith.science/pith/KGQ7KNK5OUPPCLIDAX6OA5GKDJ/bundle.json","state":"https://pith.science/pith/KGQ7KNK5OUPPCLIDAX6OA5GKDJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/KGQ7KNK5OUPPCLIDAX6OA5GKDJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:KGQ7KNK5OUPPCLIDAX6OA5GKDJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"70f9f9cc7cf52cd58ce362b896496f4bacf93b95968e56ee135a43c9dfda3811","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-11-03T11:44:22Z","title_canon_sha256":"98aeace738995a6fd3e7577c7824b5a0f3972f84d86b257a0c50e992f250d753"},"schema_version":"1.0","source":{"id":"2411.01536","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.01536","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"arxiv_version","alias_value":"2411.01536v2","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.01536","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"pith_short_12","alias_value":"KGQ7KNK5OUPP","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"pith_short_16","alias_value":"KGQ7KNK5OUPPCLID","created_at":"2026-07-05T10:55:25Z"},{"alias_kind":"pith_short_8","alias_value":"KGQ7KNK5","created_at":"2026-07-05T10:55:25Z"}],"graph_snapshots":[{"event_id":"sha256:0a99e09aca85825397f17a7c5fd0c1534e74a428926de89803463df81d4d5bf3","target":"graph","created_at":"2026-07-05T10:55:25Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2411.01536/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Living cells actively regulate their volume in response to changes in the extra-cellular environment, such as osmolarity and chemo-attractant concentration. While the basic physical mechanisms of volume regulation are understood from the classic \"pump-leak\" model, it does not provide an explicit expression for the volume during dynamic regulation and can benefit from further insight into the volume dynamics. Here, we propose a simple explanation of volume dynamics in terms of two phases: fast volume adjustment to membrane potential, largely determined by Cl$^-$ leakage, and slow potential adap","authors_text":"Ram M. Adar","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-11-03T11:44:22Z","title":"Separation of ionic timescales explains dynamics of cellular volume regulation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.01536","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:21cbc3a0da2471b682cf60d8552f5d5273807401ee4a4ab613761a39dbd97d2f","target":"record","created_at":"2026-07-05T10:55:25Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"70f9f9cc7cf52cd58ce362b896496f4bacf93b95968e56ee135a43c9dfda3811","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-11-03T11:44:22Z","title_canon_sha256":"98aeace738995a6fd3e7577c7824b5a0f3972f84d86b257a0c50e992f250d753"},"schema_version":"1.0","source":{"id":"2411.01536","kind":"arxiv","version":2}},"canonical_sha256":"51a1f5355d751ef12d0305fce074ca1a5cd4ba44bd425a5b58052b09a67243df","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"51a1f5355d751ef12d0305fce074ca1a5cd4ba44bd425a5b58052b09a67243df","first_computed_at":"2026-07-05T10:55:25.577740Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:55:25.577740Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"8nLWKs+sJp0hL6ubWsHPMJrX+6+p0bEYFKd9moyfLKXiJ+OGVzttDHhjcWkqAujCGyzu++hQEN3xyiZWwsbnBg==","signature_status":"signed_v1","signed_at":"2026-07-05T10:55:25.578254Z","signed_message":"canonical_sha256_bytes"},"source_id":"2411.01536","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:21cbc3a0da2471b682cf60d8552f5d5273807401ee4a4ab613761a39dbd97d2f","sha256:0a99e09aca85825397f17a7c5fd0c1534e74a428926de89803463df81d4d5bf3"],"state_sha256":"76df91d759335ae00a6eab42818300c41f7975163ae3cbf2102d42048a5e54ed"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"j6O7/U3DsclgTuTQWOsKdp+0v9YlnHDO3tka1QHQmms/7TzflHCcTBrwwMw3n1+GuEK0wn2+Ohwz6alQfMXIDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-09T09:04:27.839540Z","bundle_sha256":"a9281ec6c1b9059bd01747ac127c64349c854559eea3b65eb6f9a0b2dc1b4d03"}}