{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:KL5R5F3B4CWRGTZGHUFWWZSOJH","short_pith_number":"pith:KL5R5F3B","canonical_record":{"source":{"id":"1404.5324","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-21T20:32:28Z","cross_cats_sorted":[],"title_canon_sha256":"3811e43883b425648b0b43c69405b51e2f781a8f142112cfe03c58ab6f260e55","abstract_canon_sha256":"58d58f5d99f911d1993926a2900a4a592a6f255b4945e0b5dac7ed3664abdae4"},"schema_version":"1.0"},"canonical_sha256":"52fb1e9761e0ad134f263d0b6b664e49fe787f2445118755390875ba13b69d41","source":{"kind":"arxiv","id":"1404.5324","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1404.5324","created_at":"2026-05-18T02:53:39Z"},{"alias_kind":"arxiv_version","alias_value":"1404.5324v1","created_at":"2026-05-18T02:53:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1404.5324","created_at":"2026-05-18T02:53:39Z"},{"alias_kind":"pith_short_12","alias_value":"KL5R5F3B4CWR","created_at":"2026-05-18T12:28:35Z"},{"alias_kind":"pith_short_16","alias_value":"KL5R5F3B4CWRGTZG","created_at":"2026-05-18T12:28:35Z"},{"alias_kind":"pith_short_8","alias_value":"KL5R5F3B","created_at":"2026-05-18T12:28:35Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:KL5R5F3B4CWRGTZGHUFWWZSOJH","target":"record","payload":{"canonical_record":{"source":{"id":"1404.5324","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-21T20:32:28Z","cross_cats_sorted":[],"title_canon_sha256":"3811e43883b425648b0b43c69405b51e2f781a8f142112cfe03c58ab6f260e55","abstract_canon_sha256":"58d58f5d99f911d1993926a2900a4a592a6f255b4945e0b5dac7ed3664abdae4"},"schema_version":"1.0"},"canonical_sha256":"52fb1e9761e0ad134f263d0b6b664e49fe787f2445118755390875ba13b69d41","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:53:39.285528Z","signature_b64":"5bsNGPugUZuH6l5sNYEJ6vrpinG4FfYwLNeAGAQRhSMKM9YlFg1Eq0WTmcPHN/TZoijVWfExgFxyXfKk+IqhBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"52fb1e9761e0ad134f263d0b6b664e49fe787f2445118755390875ba13b69d41","last_reissued_at":"2026-05-18T02:53:39.284791Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:53:39.284791Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1404.5324","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:53:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OLzn7tiC9HPyCOP27/qixJm3ku14yhDrLZPexDpj0+9na1TkGvuSQ9oxocPacfm/e0bSK3LCg+zSJRr+Nrl1Ag==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T16:48:24.443507Z"},"content_sha256":"cd349a0699cf96108273217b63b5e6bb075d8f1db2cb3b1f5520b42c1540235a","schema_version":"1.0","event_id":"sha256:cd349a0699cf96108273217b63b5e6bb075d8f1db2cb3b1f5520b42c1540235a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:KL5R5F3B4CWRGTZGHUFWWZSOJH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"For principled model fitting in mathematical biology","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Thomas House","submitted_at":"2014-04-21T20:32:28Z","abstract_excerpt":"The mathematical models used to capture features of complex, biological systems are typically non-linear, meaning that there are no generally valid simple relationships between their outputs and the data that might be used to validate them. This invalidates the assumptions behind standard statistical methods such as linear regression, and often the methods used to parameterise biological models from data are ad hoc. In this perspective, I will argue for an approach to model fitting in mathematical biology that incorporates modern statistical methodology without losing the insights gained throu"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1404.5324","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:53:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/Ie6v5U9Lzj3K5RbD4VLSG0KauV/PJxnjiODURu29CANzFsP24nIJ7JHEXusJf1DmKIOG9YorVCOw6dN/EqnCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T16:48:24.444335Z"},"content_sha256":"676c469122a6213b6d5f0e70fc1b8fa1da69cb2102a74ca71d98fabe4fdcbc59","schema_version":"1.0","event_id":"sha256:676c469122a6213b6d5f0e70fc1b8fa1da69cb2102a74ca71d98fabe4fdcbc59"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/KL5R5F3B4CWRGTZGHUFWWZSOJH/bundle.json","state_url":"https://pith.science/pith/KL5R5F3B4CWRGTZGHUFWWZSOJH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/KL5R5F3B4CWRGTZGHUFWWZSOJH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-06T16:48:24Z","links":{"resolver":"https://pith.science/pith/KL5R5F3B4CWRGTZGHUFWWZSOJH","bundle":"https://pith.science/pith/KL5R5F3B4CWRGTZGHUFWWZSOJH/bundle.json","state":"https://pith.science/pith/KL5R5F3B4CWRGTZGHUFWWZSOJH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/KL5R5F3B4CWRGTZGHUFWWZSOJH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:KL5R5F3B4CWRGTZGHUFWWZSOJH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"58d58f5d99f911d1993926a2900a4a592a6f255b4945e0b5dac7ed3664abdae4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-21T20:32:28Z","title_canon_sha256":"3811e43883b425648b0b43c69405b51e2f781a8f142112cfe03c58ab6f260e55"},"schema_version":"1.0","source":{"id":"1404.5324","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1404.5324","created_at":"2026-05-18T02:53:39Z"},{"alias_kind":"arxiv_version","alias_value":"1404.5324v1","created_at":"2026-05-18T02:53:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1404.5324","created_at":"2026-05-18T02:53:39Z"},{"alias_kind":"pith_short_12","alias_value":"KL5R5F3B4CWR","created_at":"2026-05-18T12:28:35Z"},{"alias_kind":"pith_short_16","alias_value":"KL5R5F3B4CWRGTZG","created_at":"2026-05-18T12:28:35Z"},{"alias_kind":"pith_short_8","alias_value":"KL5R5F3B","created_at":"2026-05-18T12:28:35Z"}],"graph_snapshots":[{"event_id":"sha256:676c469122a6213b6d5f0e70fc1b8fa1da69cb2102a74ca71d98fabe4fdcbc59","target":"graph","created_at":"2026-05-18T02:53:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The mathematical models used to capture features of complex, biological systems are typically non-linear, meaning that there are no generally valid simple relationships between their outputs and the data that might be used to validate them. This invalidates the assumptions behind standard statistical methods such as linear regression, and often the methods used to parameterise biological models from data are ad hoc. In this perspective, I will argue for an approach to model fitting in mathematical biology that incorporates modern statistical methodology without losing the insights gained throu","authors_text":"Thomas House","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-21T20:32:28Z","title":"For principled model fitting in mathematical biology"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1404.5324","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cd349a0699cf96108273217b63b5e6bb075d8f1db2cb3b1f5520b42c1540235a","target":"record","created_at":"2026-05-18T02:53:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"58d58f5d99f911d1993926a2900a4a592a6f255b4945e0b5dac7ed3664abdae4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-21T20:32:28Z","title_canon_sha256":"3811e43883b425648b0b43c69405b51e2f781a8f142112cfe03c58ab6f260e55"},"schema_version":"1.0","source":{"id":"1404.5324","kind":"arxiv","version":1}},"canonical_sha256":"52fb1e9761e0ad134f263d0b6b664e49fe787f2445118755390875ba13b69d41","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"52fb1e9761e0ad134f263d0b6b664e49fe787f2445118755390875ba13b69d41","first_computed_at":"2026-05-18T02:53:39.284791Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:53:39.284791Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"5bsNGPugUZuH6l5sNYEJ6vrpinG4FfYwLNeAGAQRhSMKM9YlFg1Eq0WTmcPHN/TZoijVWfExgFxyXfKk+IqhBA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:53:39.285528Z","signed_message":"canonical_sha256_bytes"},"source_id":"1404.5324","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cd349a0699cf96108273217b63b5e6bb075d8f1db2cb3b1f5520b42c1540235a","sha256:676c469122a6213b6d5f0e70fc1b8fa1da69cb2102a74ca71d98fabe4fdcbc59"],"state_sha256":"f6fba42580d77775ef9c575697800587b22705b53d635541a035b6406fcdff41"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Y28X+7MLfEp7Nop2/Q1OebhrCp3gYujGu/XHzfnhw6iDWR9Kl/CAhdoygctrNdwD2atrwWJFFLT9BfF3u1DcAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-06T16:48:24.447194Z","bundle_sha256":"42a30b07bbed949b60474921899dd75924064080e6334cfe4ca7ab7043a792df"}}