{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:KLQYJ5JQSGIMZ7ALELOYUFQJRE","short_pith_number":"pith:KLQYJ5JQ","canonical_record":{"source":{"id":"1401.7872","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-01-30T15:02:42Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"9ede1a3aa15c0a9ef2728ca8c735e07fca623d405d585783e07ae1d7c1bcc4a1","abstract_canon_sha256":"bacf314f10eb0b6c65a3674f12ff56c04a9e1e6cf1cb9cd1d937f0f03ce881c9"},"schema_version":"1.0"},"canonical_sha256":"52e184f5309190ccfc0b22dd8a1609893dd33f088b45fcb0e1a8a1ab6c8fff66","source":{"kind":"arxiv","id":"1401.7872","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1401.7872","created_at":"2026-05-18T03:00:38Z"},{"alias_kind":"arxiv_version","alias_value":"1401.7872v1","created_at":"2026-05-18T03:00:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1401.7872","created_at":"2026-05-18T03:00:38Z"},{"alias_kind":"pith_short_12","alias_value":"KLQYJ5JQSGIM","created_at":"2026-05-18T12:28:35Z"},{"alias_kind":"pith_short_16","alias_value":"KLQYJ5JQSGIMZ7AL","created_at":"2026-05-18T12:28:35Z"},{"alias_kind":"pith_short_8","alias_value":"KLQYJ5JQ","created_at":"2026-05-18T12:28:35Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:KLQYJ5JQSGIMZ7ALELOYUFQJRE","target":"record","payload":{"canonical_record":{"source":{"id":"1401.7872","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-01-30T15:02:42Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"9ede1a3aa15c0a9ef2728ca8c735e07fca623d405d585783e07ae1d7c1bcc4a1","abstract_canon_sha256":"bacf314f10eb0b6c65a3674f12ff56c04a9e1e6cf1cb9cd1d937f0f03ce881c9"},"schema_version":"1.0"},"canonical_sha256":"52e184f5309190ccfc0b22dd8a1609893dd33f088b45fcb0e1a8a1ab6c8fff66","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:00:38.103868Z","signature_b64":"U+mCskCYVLp/ySp5nsZECcKGwry04dmEpe2Rd9v5JO+fHiaczZpJaLHgBWXHUGrU8ZLPc+YYIrm9rUQWy5izDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"52e184f5309190ccfc0b22dd8a1609893dd33f088b45fcb0e1a8a1ab6c8fff66","last_reissued_at":"2026-05-18T03:00:38.103171Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:00:38.103171Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1401.7872","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:00:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gw2sRxDXPEWrtWCgZGW7DilZFIX44VIvURs1N1zrJ1OfIKBUHnPTcdljSj6zqkNUIUj5LqPSfLxKzH5no9IXAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T02:15:34.496138Z"},"content_sha256":"3ebe292bb7e9a128e3aee61760d4903e5aae65651b87b14e981e8b0deaa82953","schema_version":"1.0","event_id":"sha256:3ebe292bb7e9a128e3aee61760d4903e5aae65651b87b14e981e8b0deaa82953"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:KLQYJ5JQSGIMZ7ALELOYUFQJRE","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"On the conflict between precision and robustness in the proportion regulation of cell types","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.CB"],"primary_cat":"physics.bio-ph","authors_text":"Harry K. MacWilliams, Ismael Rafols, Yasuji Sawada, Yasuo Maeda","submitted_at":"2014-01-30T15:02:42Z","abstract_excerpt":"In Dictyostelium discoideum the proportion of cell types is known to be actively regulated, recovering, for example, after the removal of a given cell type. However, we have recently shown that regulation is intrinsically imprecise: it controls the proportion above/below certain upper and lower thresholds, but not within an allowed range of values that these thresholds define. To explain this finding we present a model based on (i) a global negative feedback, and (ii) a cell-autonomous positive feedback leading to a hysteresis-like behaviour (i.e, a bistability of cell type). The simulated cel"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1401.7872","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:00:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dnW8XbnlHBHmcKwCpe82SETErURar0+H2625pMnnSF4J3eueqCtAiXW1twRKqiqgu21RjneNQrpo6H7bq81XDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T02:15:34.496502Z"},"content_sha256":"e4f31c77f3abf7ac2317ade6a8890155e7f12754ccba5e1d8b213c796c40d3bf","schema_version":"1.0","event_id":"sha256:e4f31c77f3abf7ac2317ade6a8890155e7f12754ccba5e1d8b213c796c40d3bf"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/KLQYJ5JQSGIMZ7ALELOYUFQJRE/bundle.json","state_url":"https://pith.science/pith/KLQYJ5JQSGIMZ7ALELOYUFQJRE/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/KLQYJ5JQSGIMZ7ALELOYUFQJRE/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-02T02:15:34Z","links":{"resolver":"https://pith.science/pith/KLQYJ5JQSGIMZ7ALELOYUFQJRE","bundle":"https://pith.science/pith/KLQYJ5JQSGIMZ7ALELOYUFQJRE/bundle.json","state":"https://pith.science/pith/KLQYJ5JQSGIMZ7ALELOYUFQJRE/state.json","well_known_bundle":"https://pith.science/.well-known/pith/KLQYJ5JQSGIMZ7ALELOYUFQJRE/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:KLQYJ5JQSGIMZ7ALELOYUFQJRE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bacf314f10eb0b6c65a3674f12ff56c04a9e1e6cf1cb9cd1d937f0f03ce881c9","cross_cats_sorted":["q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-01-30T15:02:42Z","title_canon_sha256":"9ede1a3aa15c0a9ef2728ca8c735e07fca623d405d585783e07ae1d7c1bcc4a1"},"schema_version":"1.0","source":{"id":"1401.7872","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1401.7872","created_at":"2026-05-18T03:00:38Z"},{"alias_kind":"arxiv_version","alias_value":"1401.7872v1","created_at":"2026-05-18T03:00:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1401.7872","created_at":"2026-05-18T03:00:38Z"},{"alias_kind":"pith_short_12","alias_value":"KLQYJ5JQSGIM","created_at":"2026-05-18T12:28:35Z"},{"alias_kind":"pith_short_16","alias_value":"KLQYJ5JQSGIMZ7AL","created_at":"2026-05-18T12:28:35Z"},{"alias_kind":"pith_short_8","alias_value":"KLQYJ5JQ","created_at":"2026-05-18T12:28:35Z"}],"graph_snapshots":[{"event_id":"sha256:e4f31c77f3abf7ac2317ade6a8890155e7f12754ccba5e1d8b213c796c40d3bf","target":"graph","created_at":"2026-05-18T03:00:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In Dictyostelium discoideum the proportion of cell types is known to be actively regulated, recovering, for example, after the removal of a given cell type. However, we have recently shown that regulation is intrinsically imprecise: it controls the proportion above/below certain upper and lower thresholds, but not within an allowed range of values that these thresholds define. To explain this finding we present a model based on (i) a global negative feedback, and (ii) a cell-autonomous positive feedback leading to a hysteresis-like behaviour (i.e, a bistability of cell type). The simulated cel","authors_text":"Harry K. MacWilliams, Ismael Rafols, Yasuji Sawada, Yasuo Maeda","cross_cats":["q-bio.CB"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-01-30T15:02:42Z","title":"On the conflict between precision and robustness in the proportion regulation of cell types"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1401.7872","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3ebe292bb7e9a128e3aee61760d4903e5aae65651b87b14e981e8b0deaa82953","target":"record","created_at":"2026-05-18T03:00:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bacf314f10eb0b6c65a3674f12ff56c04a9e1e6cf1cb9cd1d937f0f03ce881c9","cross_cats_sorted":["q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-01-30T15:02:42Z","title_canon_sha256":"9ede1a3aa15c0a9ef2728ca8c735e07fca623d405d585783e07ae1d7c1bcc4a1"},"schema_version":"1.0","source":{"id":"1401.7872","kind":"arxiv","version":1}},"canonical_sha256":"52e184f5309190ccfc0b22dd8a1609893dd33f088b45fcb0e1a8a1ab6c8fff66","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"52e184f5309190ccfc0b22dd8a1609893dd33f088b45fcb0e1a8a1ab6c8fff66","first_computed_at":"2026-05-18T03:00:38.103171Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:00:38.103171Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"U+mCskCYVLp/ySp5nsZECcKGwry04dmEpe2Rd9v5JO+fHiaczZpJaLHgBWXHUGrU8ZLPc+YYIrm9rUQWy5izDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:00:38.103868Z","signed_message":"canonical_sha256_bytes"},"source_id":"1401.7872","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3ebe292bb7e9a128e3aee61760d4903e5aae65651b87b14e981e8b0deaa82953","sha256:e4f31c77f3abf7ac2317ade6a8890155e7f12754ccba5e1d8b213c796c40d3bf"],"state_sha256":"27cc206b880313d629c1ac9e7c8f16173c37ee772ca1a22149359c75367587f2"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"YW9agX5JoEM7ozv2ScsBKiZmTWt/IrxIjbHJEYSx1P6IGMdXtL6wlP9oDpZ87+GlqEPnIbrqbPdSZ4tjnvi4Dg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-02T02:15:34.498367Z","bundle_sha256":"27cab4612878282913409ff79a89a067be548af143d30caada9496d63e549fe0"}}