{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:KLXP3WTJKHUFRT26PKXKP7A4UJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ffdb7b0fd7017496c5932e61ed3277a40fc14a289426821b3323d7cbfa868566","cross_cats_sorted":["physics.bio-ph","physics.chem-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2023-08-23T05:59:45Z","title_canon_sha256":"cde51a5734b8836470c0008c16961c9285bb06d4187bfee721cf4ab283ef042f"},"schema_version":"1.0","source":{"id":"2308.11936","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2308.11936","created_at":"2026-07-05T06:47:26Z"},{"alias_kind":"arxiv_version","alias_value":"2308.11936v2","created_at":"2026-07-05T06:47:26Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2308.11936","created_at":"2026-07-05T06:47:26Z"},{"alias_kind":"pith_short_12","alias_value":"KLXP3WTJKHUF","created_at":"2026-07-05T06:47:26Z"},{"alias_kind":"pith_short_16","alias_value":"KLXP3WTJKHUFRT26","created_at":"2026-07-05T06:47:26Z"},{"alias_kind":"pith_short_8","alias_value":"KLXP3WTJ","created_at":"2026-07-05T06:47:26Z"}],"graph_snapshots":[{"event_id":"sha256:4f6abacc8b9c55e13983f6031a1bd947eafb8180894b9baef46c38f8d5569ae4","target":"graph","created_at":"2026-07-05T06:47:26Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2308.11936/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"This work presents a general chemical reaction network theory for olfactory sensing processes that employ G-protein-coupled receptors as olfactory receptors (ORs). The theory is applicable to general mixtures of odorants and an arbitrary number of ORs. Reactions of ORs with G-proteins, both in the presence and the absence of odorants, are explicitly considered. A unique feature of the theory is the definition of an odor activity vector consisting of strengths of odorant-induced signals from ORs relative to those due to background G-protein activity in the absence of odorants. It is demonstrate","authors_text":"Changbong Hyeon, Kiri Choi, Seogjoo J. Jang, Won Kyu Kim","cross_cats":["physics.bio-ph","physics.chem-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2023-08-23T05:59:45Z","title":"General Chemical Reaction Network Theory for Olfactory Sensing Based on G-Protein-Coupled Receptors : Elucidation of Odorant Mixture Effects and Agonist-Synergist Threshold"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2308.11936","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:21bd00529238cbd923febf63c38794e6500fb698aed8806d20da2786c5acca08","target":"record","created_at":"2026-07-05T06:47:26Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ffdb7b0fd7017496c5932e61ed3277a40fc14a289426821b3323d7cbfa868566","cross_cats_sorted":["physics.bio-ph","physics.chem-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2023-08-23T05:59:45Z","title_canon_sha256":"cde51a5734b8836470c0008c16961c9285bb06d4187bfee721cf4ab283ef042f"},"schema_version":"1.0","source":{"id":"2308.11936","kind":"arxiv","version":2}},"canonical_sha256":"52eefdda6951e858cf5e7aaea7fc1ca258269f28df177f06fd78dfbf1136a222","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"52eefdda6951e858cf5e7aaea7fc1ca258269f28df177f06fd78dfbf1136a222","first_computed_at":"2026-07-05T06:47:26.756410Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T06:47:26.756410Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"B/K9U8jr2KMr+gyKdBfP/RpOeRDO6/kCuUBn3L6dlalRIoT1VPy47CqFuA7e5OuCWvYCsTEeSlJHzrgfX8IYCg==","signature_status":"signed_v1","signed_at":"2026-07-05T06:47:26.756989Z","signed_message":"canonical_sha256_bytes"},"source_id":"2308.11936","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:21bd00529238cbd923febf63c38794e6500fb698aed8806d20da2786c5acca08","sha256:4f6abacc8b9c55e13983f6031a1bd947eafb8180894b9baef46c38f8d5569ae4"],"state_sha256":"7c3de31939f2bb9906e9c5393b8954f853cb5bebc3e1623223e7806ff01e3859"}