{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:KOVL2WCLIAJ2PL4ZFL3UHYCRP2","short_pith_number":"pith:KOVL2WCL","canonical_record":{"source":{"id":"1210.3294","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-10-11T16:44:01Z","cross_cats_sorted":[],"title_canon_sha256":"f346ae05348a939eaf901402c96e4887ddf6ff300b5e9272dc4d82392efda74d","abstract_canon_sha256":"3493cdedf540a2e8105397759b007fef6e8686914a96d74e1593566e036af8a0"},"schema_version":"1.0"},"canonical_sha256":"53aabd584b4013a7af992af743e0517ea1331ddb492a1f914fb1072331a9d563","source":{"kind":"arxiv","id":"1210.3294","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1210.3294","created_at":"2026-05-18T01:27:15Z"},{"alias_kind":"arxiv_version","alias_value":"1210.3294v1","created_at":"2026-05-18T01:27:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1210.3294","created_at":"2026-05-18T01:27:15Z"},{"alias_kind":"pith_short_12","alias_value":"KOVL2WCLIAJ2","created_at":"2026-05-18T12:27:11Z"},{"alias_kind":"pith_short_16","alias_value":"KOVL2WCLIAJ2PL4Z","created_at":"2026-05-18T12:27:11Z"},{"alias_kind":"pith_short_8","alias_value":"KOVL2WCL","created_at":"2026-05-18T12:27:11Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:KOVL2WCLIAJ2PL4ZFL3UHYCRP2","target":"record","payload":{"canonical_record":{"source":{"id":"1210.3294","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-10-11T16:44:01Z","cross_cats_sorted":[],"title_canon_sha256":"f346ae05348a939eaf901402c96e4887ddf6ff300b5e9272dc4d82392efda74d","abstract_canon_sha256":"3493cdedf540a2e8105397759b007fef6e8686914a96d74e1593566e036af8a0"},"schema_version":"1.0"},"canonical_sha256":"53aabd584b4013a7af992af743e0517ea1331ddb492a1f914fb1072331a9d563","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:27:15.515896Z","signature_b64":"SXdGbdazbGrkO9KCjak+2FCok/8FkBvutcL9p5Le6bl4epxdIYQIqrw7wZPXt5C/5MbJdQvTLHLM3qLzfg1zBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"53aabd584b4013a7af992af743e0517ea1331ddb492a1f914fb1072331a9d563","last_reissued_at":"2026-05-18T01:27:15.515388Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:27:15.515388Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1210.3294","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:27:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0DZdKgLJ6CNdC0Yh1wTdl159waNAERS+u9BM10zcygLzl1NwMadksfaKXWbW6H+bXLBKOL9FJtte3MY4HX30CQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T05:41:03.295613Z"},"content_sha256":"ccbf3fdbe78fc530ecd56eee2e7df06b228519801330b46cfee5ed7a3b20a031","schema_version":"1.0","event_id":"sha256:ccbf3fdbe78fc530ecd56eee2e7df06b228519801330b46cfee5ed7a3b20a031"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:KOVL2WCLIAJ2PL4ZFL3UHYCRP2","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Integrative modeling of eQTLs and cis-regulatory elements suggest mechanisms underlying cell type specificity of eQTLs","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.GN","authors_text":"Barbara E Engelhardt, Christopher D Brown, Lara M Mangravite","submitted_at":"2012-10-11T16:44:01Z","abstract_excerpt":"Genetic variants in cis-regulatory elements or trans-acting regulators commonly influence the quantity and spatiotemporal distribution of gene transcription. Recent interest in expression quantitative trait locus (eQTL) mapping has paralleled the adoption of genome-wide association studies (GWAS) for the analysis of complex traits and disease in humans. Under the hypothesis that many GWAS associations tag non-coding SNPs with small effects, and that these SNPs exert phenotypic control by modifying gene expression, it has become common to interpret GWAS associations using eQTL data. To exploit "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1210.3294","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:27:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Bd1fat6IVdvjespN6j8v+5jGj+NaPI4l/6cdKznK7JVapvRDQhHrjliUhyopHNam9ilzQCnlB2UuAb8zMKM2AA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T05:41:03.296279Z"},"content_sha256":"19e8936d6234b7ce136cd19aff03f0a605b0f1e1c56ffd1f0dc3e9bac70a25fd","schema_version":"1.0","event_id":"sha256:19e8936d6234b7ce136cd19aff03f0a605b0f1e1c56ffd1f0dc3e9bac70a25fd"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/KOVL2WCLIAJ2PL4ZFL3UHYCRP2/bundle.json","state_url":"https://pith.science/pith/KOVL2WCLIAJ2PL4ZFL3UHYCRP2/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/KOVL2WCLIAJ2PL4ZFL3UHYCRP2/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T05:41:03Z","links":{"resolver":"https://pith.science/pith/KOVL2WCLIAJ2PL4ZFL3UHYCRP2","bundle":"https://pith.science/pith/KOVL2WCLIAJ2PL4ZFL3UHYCRP2/bundle.json","state":"https://pith.science/pith/KOVL2WCLIAJ2PL4ZFL3UHYCRP2/state.json","well_known_bundle":"https://pith.science/.well-known/pith/KOVL2WCLIAJ2PL4ZFL3UHYCRP2/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:KOVL2WCLIAJ2PL4ZFL3UHYCRP2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"3493cdedf540a2e8105397759b007fef6e8686914a96d74e1593566e036af8a0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-10-11T16:44:01Z","title_canon_sha256":"f346ae05348a939eaf901402c96e4887ddf6ff300b5e9272dc4d82392efda74d"},"schema_version":"1.0","source":{"id":"1210.3294","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1210.3294","created_at":"2026-05-18T01:27:15Z"},{"alias_kind":"arxiv_version","alias_value":"1210.3294v1","created_at":"2026-05-18T01:27:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1210.3294","created_at":"2026-05-18T01:27:15Z"},{"alias_kind":"pith_short_12","alias_value":"KOVL2WCLIAJ2","created_at":"2026-05-18T12:27:11Z"},{"alias_kind":"pith_short_16","alias_value":"KOVL2WCLIAJ2PL4Z","created_at":"2026-05-18T12:27:11Z"},{"alias_kind":"pith_short_8","alias_value":"KOVL2WCL","created_at":"2026-05-18T12:27:11Z"}],"graph_snapshots":[{"event_id":"sha256:19e8936d6234b7ce136cd19aff03f0a605b0f1e1c56ffd1f0dc3e9bac70a25fd","target":"graph","created_at":"2026-05-18T01:27:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Genetic variants in cis-regulatory elements or trans-acting regulators commonly influence the quantity and spatiotemporal distribution of gene transcription. Recent interest in expression quantitative trait locus (eQTL) mapping has paralleled the adoption of genome-wide association studies (GWAS) for the analysis of complex traits and disease in humans. Under the hypothesis that many GWAS associations tag non-coding SNPs with small effects, and that these SNPs exert phenotypic control by modifying gene expression, it has become common to interpret GWAS associations using eQTL data. To exploit ","authors_text":"Barbara E Engelhardt, Christopher D Brown, Lara M Mangravite","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-10-11T16:44:01Z","title":"Integrative modeling of eQTLs and cis-regulatory elements suggest mechanisms underlying cell type specificity of eQTLs"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1210.3294","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ccbf3fdbe78fc530ecd56eee2e7df06b228519801330b46cfee5ed7a3b20a031","target":"record","created_at":"2026-05-18T01:27:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"3493cdedf540a2e8105397759b007fef6e8686914a96d74e1593566e036af8a0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-10-11T16:44:01Z","title_canon_sha256":"f346ae05348a939eaf901402c96e4887ddf6ff300b5e9272dc4d82392efda74d"},"schema_version":"1.0","source":{"id":"1210.3294","kind":"arxiv","version":1}},"canonical_sha256":"53aabd584b4013a7af992af743e0517ea1331ddb492a1f914fb1072331a9d563","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"53aabd584b4013a7af992af743e0517ea1331ddb492a1f914fb1072331a9d563","first_computed_at":"2026-05-18T01:27:15.515388Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:27:15.515388Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"SXdGbdazbGrkO9KCjak+2FCok/8FkBvutcL9p5Le6bl4epxdIYQIqrw7wZPXt5C/5MbJdQvTLHLM3qLzfg1zBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:27:15.515896Z","signed_message":"canonical_sha256_bytes"},"source_id":"1210.3294","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ccbf3fdbe78fc530ecd56eee2e7df06b228519801330b46cfee5ed7a3b20a031","sha256:19e8936d6234b7ce136cd19aff03f0a605b0f1e1c56ffd1f0dc3e9bac70a25fd"],"state_sha256":"6e943e373873f6e1d7830fc65dccaf35272de9de38ddfdc22309392098d5ac14"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"toALD6aqfg0wGperV1G+zxFdMv+Puddoljq6CxVHTEz3mpBBaSAuYbS6pd3n3pTaIEmlPcxmK9J/epaPBGR1DA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T05:41:03.300024Z","bundle_sha256":"2ab5d860623da3a818438b96e1099b64ae6bb98c8b3f76ed7aa1d0360b191249"}}