{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:KU5IMTLZT332Z4OYZPNVC3YHAH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"35937c65cdf8b4c6caf27e2ff8bae2565da83ea7583bd5851bdcc53522ea9df7","cross_cats_sorted":["physics.bio-ph","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2018-08-03T11:56:35Z","title_canon_sha256":"8ce20080125b3814d601c51a093497eb182823b2cf41dda86b7b3e91a4b0b650"},"schema_version":"1.0","source":{"id":"1808.01168","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1808.01168","created_at":"2026-05-18T00:08:58Z"},{"alias_kind":"arxiv_version","alias_value":"1808.01168v1","created_at":"2026-05-18T00:08:58Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1808.01168","created_at":"2026-05-18T00:08:58Z"},{"alias_kind":"pith_short_12","alias_value":"KU5IMTLZT332","created_at":"2026-05-18T12:32:33Z"},{"alias_kind":"pith_short_16","alias_value":"KU5IMTLZT332Z4OY","created_at":"2026-05-18T12:32:33Z"},{"alias_kind":"pith_short_8","alias_value":"KU5IMTLZ","created_at":"2026-05-18T12:32:33Z"}],"graph_snapshots":[{"event_id":"sha256:3f4bdba48d0e57a34dd1052e43cc4e1a306980f80dcd9eca77d7bda973b141b5","target":"graph","created_at":"2026-05-18T00:08:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In combining DNA nanotechnology and high-bandwidth single-molecule detection in nanopipettes, we demonstrate an all-electric, label-free hybridisation sensor for short DNA sequences (< 100 nt). Such short fragments are known to occur as circulating cell-free DNA in various bodily fluids, such as blood plasma and saliva, and have been identified as disease markers for cancer and infectious diseases. To this end, we use as a model system a 88-mer target from the RV1910c gene in Mycobacterium tuberculosis that is associated with antibiotic (isoniazid) resistance in TB. Upon binding to short probe","authors_text":"Amelia Y.Y. Loh, Anthony E.G. Cass, Claire H. Burgess, Diana A. Tanase, Giorgio Ferrari, Martyn A. McLachlan, Tim Albrecht","cross_cats":["physics.bio-ph","q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2018-08-03T11:56:35Z","title":"An All-Electric Single-Molecule Hybridisation Detector for short DNA Fragments"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1808.01168","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1c1b6a1bf65daf08f58aa9f5d4469c4a259e3028b6cbb73e2be325cc1916e550","target":"record","created_at":"2026-05-18T00:08:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"35937c65cdf8b4c6caf27e2ff8bae2565da83ea7583bd5851bdcc53522ea9df7","cross_cats_sorted":["physics.bio-ph","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2018-08-03T11:56:35Z","title_canon_sha256":"8ce20080125b3814d601c51a093497eb182823b2cf41dda86b7b3e91a4b0b650"},"schema_version":"1.0","source":{"id":"1808.01168","kind":"arxiv","version":1}},"canonical_sha256":"553a864d799ef7acf1d8cbdb516f0701d7a26d5bfac54e42a2784103bddace4a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"553a864d799ef7acf1d8cbdb516f0701d7a26d5bfac54e42a2784103bddace4a","first_computed_at":"2026-05-18T00:08:58.779131Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:08:58.779131Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"L0bNgUBayESpuu2Fe4LvneKgWpehBqVHw6zR0pkI/s9EEdEgPmbEBGhRIeu+V24hBGWQstFxN+H8J5PjgsQ7Cg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:08:58.779665Z","signed_message":"canonical_sha256_bytes"},"source_id":"1808.01168","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1c1b6a1bf65daf08f58aa9f5d4469c4a259e3028b6cbb73e2be325cc1916e550","sha256:3f4bdba48d0e57a34dd1052e43cc4e1a306980f80dcd9eca77d7bda973b141b5"],"state_sha256":"086231990e82532abe7f281e98d5b4b2cdf006a52b3a3f7b6ba194c1c6932828"}