{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:KUKT7DKVHL2OHE6US47OH6XD22","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"31b784393101b0b0eddd18d628bd1082c5df9403445c2ce12af41b275c65bf09","cross_cats_sorted":["cs.AI"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-09T03:54:49Z","title_canon_sha256":"66cd5a0c8446a75553d0159b006dd25dc9e6ba1b27e12086cfa97d3722da0274"},"schema_version":"1.0","source":{"id":"2606.11264","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.11264","created_at":"2026-06-11T00:08:15Z"},{"alias_kind":"arxiv_version","alias_value":"2606.11264v1","created_at":"2026-06-11T00:08:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.11264","created_at":"2026-06-11T00:08:15Z"},{"alias_kind":"pith_short_12","alias_value":"KUKT7DKVHL2O","created_at":"2026-06-11T00:08:15Z"},{"alias_kind":"pith_short_16","alias_value":"KUKT7DKVHL2OHE6U","created_at":"2026-06-11T00:08:15Z"},{"alias_kind":"pith_short_8","alias_value":"KUKT7DKV","created_at":"2026-06-11T00:08:15Z"}],"graph_snapshots":[{"event_id":"sha256:4c11dfeb944fe730e4e03c6b60bfa2a87da2880f17c9e2dbe95068c8de32cd0c","target":"graph","created_at":"2026-06-11T00:08:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.11264/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Health digital twins (HDTs) promise patient-specific modeling and decision support but current approaches remain structurally fragmented: monolithic models that address a single organ or task lack cross-scale fidelity, while system-level twins lack generalizable architectural frameworks. We propose OmniBioTwin, a System-of-Twinned-Systems (SoTS) framework that organizes HDTs as modular computational entities coupled through explicit interaction operators within a multi-layer network architecture. The framework comprises seven coordinated layers - spanning data integration, autonomous twin mode","authors_text":"Jiang Bian, Yu Huang, Zhaohui Wang","cross_cats":["cs.AI"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-09T03:54:49Z","title":"OmniBioTwin: A System-of-Twinned-Systems Framework for Health Digital Twins"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.11264","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5ce1695c591d4a411f4e752a454bc1371cb517adbabac6690bfbebfe950bb803","target":"record","created_at":"2026-06-11T00:08:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"31b784393101b0b0eddd18d628bd1082c5df9403445c2ce12af41b275c65bf09","cross_cats_sorted":["cs.AI"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-09T03:54:49Z","title_canon_sha256":"66cd5a0c8446a75553d0159b006dd25dc9e6ba1b27e12086cfa97d3722da0274"},"schema_version":"1.0","source":{"id":"2606.11264","kind":"arxiv","version":1}},"canonical_sha256":"55153f8d553af4e393d4973ee3fae3d6aa04ceb4b3814b5affaab6345e84a242","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"55153f8d553af4e393d4973ee3fae3d6aa04ceb4b3814b5affaab6345e84a242","first_computed_at":"2026-06-11T00:08:15.523535Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-11T00:08:15.523535Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nE1JFiQcPwULmWIFSiPdyVWOkKMmR3mTTtRjj4IsvsJUXooyuOLf1Wm4CNc/tEuhbFbMSeWYpa9V0HS8lT9aDA==","signature_status":"signed_v1","signed_at":"2026-06-11T00:08:15.524621Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.11264","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5ce1695c591d4a411f4e752a454bc1371cb517adbabac6690bfbebfe950bb803","sha256:4c11dfeb944fe730e4e03c6b60bfa2a87da2880f17c9e2dbe95068c8de32cd0c"],"state_sha256":"1e32be3a637be9cc0654006b19b6dddab07c8a0a9c37a9f99c13866e52f4b927"}