{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:KVJ3DAIKM3WIACSHHFNAGCNTFS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"65486d11f941b7e6a0993c4ba3897f4eaca039614c162e13d56afbff5b762260","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-01-06T19:53:12Z","title_canon_sha256":"882cc728f1eab6a2d10337a203e44e358ec13fe398483203f65cf1ab6d246b49"},"schema_version":"1.0","source":{"id":"1501.01282","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1501.01282","created_at":"2026-05-18T02:29:55Z"},{"alias_kind":"arxiv_version","alias_value":"1501.01282v1","created_at":"2026-05-18T02:29:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1501.01282","created_at":"2026-05-18T02:29:55Z"},{"alias_kind":"pith_short_12","alias_value":"KVJ3DAIKM3WI","created_at":"2026-05-18T12:29:29Z"},{"alias_kind":"pith_short_16","alias_value":"KVJ3DAIKM3WIACSH","created_at":"2026-05-18T12:29:29Z"},{"alias_kind":"pith_short_8","alias_value":"KVJ3DAIK","created_at":"2026-05-18T12:29:29Z"}],"graph_snapshots":[{"event_id":"sha256:994f5e14d5910c3e535d698d80e03586092f7c1ade54ba1c1da155e3e31f6847","target":"graph","created_at":"2026-05-18T02:29:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We model the evolution of eukaryotic protein-protein interaction (PPI) networks. In our model, PPI networks evolve by two known biological mechanisms: (1) Gene duplication, which is followed by rapid diversification of duplicate interactions. (2) Neofunctionalization, in which a mutation leads to a new interaction with some other protein. Since many interactions are due to simple surface compatibility, we hypothesize there is an increased likelihood of interacting with other proteins in the target protein's neighborhood. We find good agreement of the model on 10 different network properties co","authors_text":"Jack Peterson, Ken A. Dill, Kristin S. Peterson, Steve Presse","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-01-06T19:53:12Z","title":"Simulated evolution of protein-protein interaction networks with realistic topology"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1501.01282","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3446947a4bb09184602b755df4e049bcb119e6fe27dec3e0e7921b63afe118e2","target":"record","created_at":"2026-05-18T02:29:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"65486d11f941b7e6a0993c4ba3897f4eaca039614c162e13d56afbff5b762260","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-01-06T19:53:12Z","title_canon_sha256":"882cc728f1eab6a2d10337a203e44e358ec13fe398483203f65cf1ab6d246b49"},"schema_version":"1.0","source":{"id":"1501.01282","kind":"arxiv","version":1}},"canonical_sha256":"5553b1810a66ec800a47395a0309b32c9e514edff637b87bdd1d75d5a2db5762","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"5553b1810a66ec800a47395a0309b32c9e514edff637b87bdd1d75d5a2db5762","first_computed_at":"2026-05-18T02:29:55.495680Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:29:55.495680Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"LANwYCS2HQ+orES7NOoKuO57JPsDTo+OeXjW6GxO3zGjVsN52Kryi9rsUqJA+Vg2JoMV9yX2ZtcgNH/8i568Bw==","signature_status":"signed_v1","signed_at":"2026-05-18T02:29:55.496041Z","signed_message":"canonical_sha256_bytes"},"source_id":"1501.01282","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3446947a4bb09184602b755df4e049bcb119e6fe27dec3e0e7921b63afe118e2","sha256:994f5e14d5910c3e535d698d80e03586092f7c1ade54ba1c1da155e3e31f6847"],"state_sha256":"2d670d70f358ba557b9ffbc3d305423f45d692bfba075e8d6a0d419289c0bcaf"}