{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2018:KZAXQDXDE56EGSNN4OB53P76X2","short_pith_number":"pith:KZAXQDXD","schema_version":"1.0","canonical_sha256":"5641780ee3277c4349ade383ddbffebe8b01a353c841769049565ff496f7b56d","source":{"kind":"arxiv","id":"1803.04957","version":1},"attestation_state":"computed","paper":{"title":"Common anesthetic molecules prefer to partition in liquid disorder phase domain in a composite multicomponent membrane","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"cond-mat.soft","authors_text":"Anirban Polley","submitted_at":"2018-03-13T17:51:19Z","abstract_excerpt":"Despite a vast clinical application of anesthetics, the molecular level of understanding of general anesthesia is far from our reach. Using atomistic molecular dynamics simulation, we study the effects of common anesthetics: ethanol, chloroform and methanol in the fully hydrated symmetric multicomponent lipid bilayer membrane comprising of an unsaturated palmitoyl-oleoyl-phosphatidyl-choline (POPC), a saturated palmitoyl-sphingomyelin (PSM) and cholesterol (Chol) which exhibits phase coexistence of liquid-ordered (lo) - liquid disordered (ld) phase domains. We find that the mechanical and phys"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1803.04957","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2018-03-13T17:51:19Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"7c7e145a7e728a8439788483a9e35d7877eb78c69752574ad7e54217976843e6","abstract_canon_sha256":"061093040751a3a362a8e20fff135903ba4824c243a00dedba23c3e9249aab63"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:10:02.456274Z","signature_b64":"3lKap/YDEjpBfTR1LbnRnWqXtKgESmGcIXuL/fdA6ICtsp2NpOst073equLjHJ4NMqMhDBba0tszka/QTNiyDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5641780ee3277c4349ade383ddbffebe8b01a353c841769049565ff496f7b56d","last_reissued_at":"2026-05-18T00:10:02.455625Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:10:02.455625Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Common anesthetic molecules prefer to partition in liquid disorder phase domain in a composite multicomponent membrane","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"cond-mat.soft","authors_text":"Anirban Polley","submitted_at":"2018-03-13T17:51:19Z","abstract_excerpt":"Despite a vast clinical application of anesthetics, the molecular level of understanding of general anesthesia is far from our reach. Using atomistic molecular dynamics simulation, we study the effects of common anesthetics: ethanol, chloroform and methanol in the fully hydrated symmetric multicomponent lipid bilayer membrane comprising of an unsaturated palmitoyl-oleoyl-phosphatidyl-choline (POPC), a saturated palmitoyl-sphingomyelin (PSM) and cholesterol (Chol) which exhibits phase coexistence of liquid-ordered (lo) - liquid disordered (ld) phase domains. We find that the mechanical and phys"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1803.04957","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1803.04957","created_at":"2026-05-18T00:10:02.455754+00:00"},{"alias_kind":"arxiv_version","alias_value":"1803.04957v1","created_at":"2026-05-18T00:10:02.455754+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1803.04957","created_at":"2026-05-18T00:10:02.455754+00:00"},{"alias_kind":"pith_short_12","alias_value":"KZAXQDXDE56E","created_at":"2026-05-18T12:32:33.847187+00:00"},{"alias_kind":"pith_short_16","alias_value":"KZAXQDXDE56EGSNN","created_at":"2026-05-18T12:32:33.847187+00:00"},{"alias_kind":"pith_short_8","alias_value":"KZAXQDXD","created_at":"2026-05-18T12:32:33.847187+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2","json":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2.json","graph_json":"https://pith.science/api/pith-number/KZAXQDXDE56EGSNN4OB53P76X2/graph.json","events_json":"https://pith.science/api/pith-number/KZAXQDXDE56EGSNN4OB53P76X2/events.json","paper":"https://pith.science/paper/KZAXQDXD"},"agent_actions":{"view_html":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2","download_json":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2.json","view_paper":"https://pith.science/paper/KZAXQDXD","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1803.04957&json=true","fetch_graph":"https://pith.science/api/pith-number/KZAXQDXDE56EGSNN4OB53P76X2/graph.json","fetch_events":"https://pith.science/api/pith-number/KZAXQDXDE56EGSNN4OB53P76X2/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2/action/timestamp_anchor","attest_storage":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2/action/storage_attestation","attest_author":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2/action/author_attestation","sign_citation":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2/action/citation_signature","submit_replication":"https://pith.science/pith/KZAXQDXDE56EGSNN4OB53P76X2/action/replication_record"}},"created_at":"2026-05-18T00:10:02.455754+00:00","updated_at":"2026-05-18T00:10:02.455754+00:00"}