{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:L2MQHRFPPS2NQGBHPZK3NRFVAH","short_pith_number":"pith:L2MQHRFP","canonical_record":{"source":{"id":"2502.08772","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-02-12T20:26:24Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"3735b973b7901d4e95bca1275f367a78821e9115954ed2ef50e61bdbf2e9b4ba","abstract_canon_sha256":"71dfe314a25cf7b6fea80aee74759e32e7c28b7d4de1fe961a34c40a46623907"},"schema_version":"1.0"},"canonical_sha256":"5e9903c4af7cb4d818277e55b6c4b501df49385d7c51f4ea458ad386465f58c1","source":{"kind":"arxiv","id":"2502.08772","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.08772","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"arxiv_version","alias_value":"2502.08772v2","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.08772","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"pith_short_12","alias_value":"L2MQHRFPPS2N","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"pith_short_16","alias_value":"L2MQHRFPPS2NQGBH","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"pith_short_8","alias_value":"L2MQHRFP","created_at":"2026-07-05T10:41:20Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:L2MQHRFPPS2NQGBHPZK3NRFVAH","target":"record","payload":{"canonical_record":{"source":{"id":"2502.08772","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-02-12T20:26:24Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"3735b973b7901d4e95bca1275f367a78821e9115954ed2ef50e61bdbf2e9b4ba","abstract_canon_sha256":"71dfe314a25cf7b6fea80aee74759e32e7c28b7d4de1fe961a34c40a46623907"},"schema_version":"1.0"},"canonical_sha256":"5e9903c4af7cb4d818277e55b6c4b501df49385d7c51f4ea458ad386465f58c1","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:41:20.523357Z","signature_b64":"Heb+w3NqDUilkXaOGukxL7z6SMG8iUs0bUt3H82Tvwe56tAxKrqWw5OAWkff4t6zPx+H8HvHMMUw9vBDrnbWDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5e9903c4af7cb4d818277e55b6c4b501df49385d7c51f4ea458ad386465f58c1","last_reissued_at":"2026-07-05T10:41:20.522894Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:41:20.522894Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2502.08772","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:41:20Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+cNTOOkXBwTx+v5DwUbGQm4WTsQrPBQQ/RTzkI9UJMa8hP09C21rcRapyL0yOlt74ybf6WkWmvEK5mtsLGxsDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-14T00:31:08.796436Z"},"content_sha256":"524cbeac74ef650d90cfac5ead1fd70612671093697c39ed170b9ced302a79db","schema_version":"1.0","event_id":"sha256:524cbeac74ef650d90cfac5ead1fd70612671093697c39ed170b9ced302a79db"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:L2MQHRFPPS2NQGBHPZK3NRFVAH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Persistent Sheaf Laplacian Analysis of Protein Flexibility","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.BM","authors_text":"Ekaterina Merkurjev, Guo-Wei Wei, Hongsong Feng, Nicole Hayes, Xiaoqi Wei","submitted_at":"2025-02-12T20:26:24Z","abstract_excerpt":"Protein flexibility, measured by the B-factor or Debye-Waller factor, is essential for protein functions such as structural support, enzyme activity, cellular communication, and molecular transport. Theoretical analysis and prediction of protein flexibility are crucial for protein design, engineering, and drug discovery. In this work, we introduce the persistent sheaf Laplacian (PSL), an effective tool in topological data analysis, to model and analyze protein flexibility. By representing the local topology and geometry of protein atoms through the multiscale harmonic and non-harmonic spectra "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.08772","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2502.08772/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:41:20Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"71zJmMZD4cvanhFJAyaI5rUrZi4iA7Mo6F1Cr7E4mZDe/n1ZuvOwxusEGvsYjdcXalYYNBKLtP6Dr5MLi/s8Ag==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-14T00:31:08.796947Z"},"content_sha256":"b77d6bcb31e15118285c5772750346411abd30bb02e471ebc41e8145eb82ed23","schema_version":"1.0","event_id":"sha256:b77d6bcb31e15118285c5772750346411abd30bb02e471ebc41e8145eb82ed23"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/L2MQHRFPPS2NQGBHPZK3NRFVAH/bundle.json","state_url":"https://pith.science/pith/L2MQHRFPPS2NQGBHPZK3NRFVAH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/L2MQHRFPPS2NQGBHPZK3NRFVAH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-14T00:31:08Z","links":{"resolver":"https://pith.science/pith/L2MQHRFPPS2NQGBHPZK3NRFVAH","bundle":"https://pith.science/pith/L2MQHRFPPS2NQGBHPZK3NRFVAH/bundle.json","state":"https://pith.science/pith/L2MQHRFPPS2NQGBHPZK3NRFVAH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/L2MQHRFPPS2NQGBHPZK3NRFVAH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:L2MQHRFPPS2NQGBHPZK3NRFVAH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"71dfe314a25cf7b6fea80aee74759e32e7c28b7d4de1fe961a34c40a46623907","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-02-12T20:26:24Z","title_canon_sha256":"3735b973b7901d4e95bca1275f367a78821e9115954ed2ef50e61bdbf2e9b4ba"},"schema_version":"1.0","source":{"id":"2502.08772","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.08772","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"arxiv_version","alias_value":"2502.08772v2","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.08772","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"pith_short_12","alias_value":"L2MQHRFPPS2N","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"pith_short_16","alias_value":"L2MQHRFPPS2NQGBH","created_at":"2026-07-05T10:41:20Z"},{"alias_kind":"pith_short_8","alias_value":"L2MQHRFP","created_at":"2026-07-05T10:41:20Z"}],"graph_snapshots":[{"event_id":"sha256:b77d6bcb31e15118285c5772750346411abd30bb02e471ebc41e8145eb82ed23","target":"graph","created_at":"2026-07-05T10:41:20Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2502.08772/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Protein flexibility, measured by the B-factor or Debye-Waller factor, is essential for protein functions such as structural support, enzyme activity, cellular communication, and molecular transport. Theoretical analysis and prediction of protein flexibility are crucial for protein design, engineering, and drug discovery. In this work, we introduce the persistent sheaf Laplacian (PSL), an effective tool in topological data analysis, to model and analyze protein flexibility. By representing the local topology and geometry of protein atoms through the multiscale harmonic and non-harmonic spectra ","authors_text":"Ekaterina Merkurjev, Guo-Wei Wei, Hongsong Feng, Nicole Hayes, Xiaoqi Wei","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-02-12T20:26:24Z","title":"Persistent Sheaf Laplacian Analysis of Protein Flexibility"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.08772","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:524cbeac74ef650d90cfac5ead1fd70612671093697c39ed170b9ced302a79db","target":"record","created_at":"2026-07-05T10:41:20Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"71dfe314a25cf7b6fea80aee74759e32e7c28b7d4de1fe961a34c40a46623907","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2025-02-12T20:26:24Z","title_canon_sha256":"3735b973b7901d4e95bca1275f367a78821e9115954ed2ef50e61bdbf2e9b4ba"},"schema_version":"1.0","source":{"id":"2502.08772","kind":"arxiv","version":2}},"canonical_sha256":"5e9903c4af7cb4d818277e55b6c4b501df49385d7c51f4ea458ad386465f58c1","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"5e9903c4af7cb4d818277e55b6c4b501df49385d7c51f4ea458ad386465f58c1","first_computed_at":"2026-07-05T10:41:20.522894Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:41:20.522894Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Heb+w3NqDUilkXaOGukxL7z6SMG8iUs0bUt3H82Tvwe56tAxKrqWw5OAWkff4t6zPx+H8HvHMMUw9vBDrnbWDA==","signature_status":"signed_v1","signed_at":"2026-07-05T10:41:20.523357Z","signed_message":"canonical_sha256_bytes"},"source_id":"2502.08772","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:524cbeac74ef650d90cfac5ead1fd70612671093697c39ed170b9ced302a79db","sha256:b77d6bcb31e15118285c5772750346411abd30bb02e471ebc41e8145eb82ed23"],"state_sha256":"8d93a839ec10ed764e0b12a02f6aaf38db04d2aca4ff6fb5921afcbdded1d3c1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"N+cz7oElwu56iTBk0B21rO/qOZlvNYQU637L8ctUydS/BWqb1y3or85/NwmPnJ5sBbXE9S/4DE1nlG+5jgNhAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-14T00:31:08.803385Z","bundle_sha256":"ad821f1a43e270c45d8c31d169f08fe809dd550d82ccafafb704272cd4f84d51"}}