{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:L4XLWBYH5F337MHYE2EU3EC5OC","short_pith_number":"pith:L4XLWBYH","canonical_record":{"source":{"id":"2502.17759","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2025-02-25T01:25:49Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"f8740f534e2e1f4af1fa3f2fb00edc5de373a723b819ae7593482e38477cf107","abstract_canon_sha256":"899c24b35f8afaa03066c2dfea33a4253d73e0acb4c43f147e8d84e3595f9c03"},"schema_version":"1.0"},"canonical_sha256":"5f2ebb0707e977bfb0f826894d905d70babf0ec9a16089a166ef59a6d436d0a3","source":{"kind":"arxiv","id":"2502.17759","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.17759","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"arxiv_version","alias_value":"2502.17759v1","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.17759","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"pith_short_12","alias_value":"L4XLWBYH5F33","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"pith_short_16","alias_value":"L4XLWBYH5F337MHY","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"pith_short_8","alias_value":"L4XLWBYH","created_at":"2026-07-05T10:19:43Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:L4XLWBYH5F337MHYE2EU3EC5OC","target":"record","payload":{"canonical_record":{"source":{"id":"2502.17759","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2025-02-25T01:25:49Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"f8740f534e2e1f4af1fa3f2fb00edc5de373a723b819ae7593482e38477cf107","abstract_canon_sha256":"899c24b35f8afaa03066c2dfea33a4253d73e0acb4c43f147e8d84e3595f9c03"},"schema_version":"1.0"},"canonical_sha256":"5f2ebb0707e977bfb0f826894d905d70babf0ec9a16089a166ef59a6d436d0a3","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:19:43.554455Z","signature_b64":"3hQlYivddQh5emF2xGZu3y7e74MxQShrjFnZb9/Ed1hWjYJm60DVmYjp5nq6YnzoomdoXDDUHKf1OUKuM1gEDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5f2ebb0707e977bfb0f826894d905d70babf0ec9a16089a166ef59a6d436d0a3","last_reissued_at":"2026-07-05T10:19:43.553945Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:19:43.553945Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2502.17759","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:19:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"y2CemlxJw5OiLd/cPR0ZGM0wLLuXcynozAQxwIaFJlIuLSEJ5s81QtaS29yUnAxjBULWvHc2VJPjthrQWSpkCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-06T11:29:58.733297Z"},"content_sha256":"8d0d7a4b1d6941b854ec731805251237cd56ba5ea29bcd9cea9d70312da95ad6","schema_version":"1.0","event_id":"sha256:8d0d7a4b1d6941b854ec731805251237cd56ba5ea29bcd9cea9d70312da95ad6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:L4XLWBYH5F337MHYE2EU3EC5OC","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Label-free Prediction of Vascular Connectivity in Perfused Microvascular Networks in vitro","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.CV"],"primary_cat":"eess.IV","authors_text":"Chen Han, Jie Gao, Liang Xu, Mingzhai Sun, Min Ye, Pengwu Song, Peng Yao, Qingdong Zhang, Ronald X. Xu, Ru Zhang, Shilu Zhu, Yang Zhang, Zhiyuan Zheng","submitted_at":"2025-02-25T01:25:49Z","abstract_excerpt":"Continuous monitoring and in-situ assessment of microvascular connectivity have significant implications for culturing vascularized organoids and optimizing the therapeutic strategies. However, commonly used methods for vascular connectivity assessment heavily rely on fluorescent labels that may either raise biocompatibility concerns or interrupt the normal cell growth process. To address this issue, a Vessel Connectivity Network (VC-Net) was developed for label-free assessment of vascular connectivity. To validate the VC-Net, microvascular networks (MVNs) were cultured in vitro and their micr"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.17759","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2502.17759/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:19:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"haqDHpLvyVbCOy1vR7z1pFxqjvHEv1EqvcASH2rn4/2LSBpe2v2FP2lEdJCpOW8kNeTj3jA3OHIzsHcBHe4QAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-06T11:29:58.733681Z"},"content_sha256":"9d0bad71c027c36694ee344996132c77b115604a3c93831075c059df8caa2741","schema_version":"1.0","event_id":"sha256:9d0bad71c027c36694ee344996132c77b115604a3c93831075c059df8caa2741"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/L4XLWBYH5F337MHYE2EU3EC5OC/bundle.json","state_url":"https://pith.science/pith/L4XLWBYH5F337MHYE2EU3EC5OC/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/L4XLWBYH5F337MHYE2EU3EC5OC/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-06T11:29:58Z","links":{"resolver":"https://pith.science/pith/L4XLWBYH5F337MHYE2EU3EC5OC","bundle":"https://pith.science/pith/L4XLWBYH5F337MHYE2EU3EC5OC/bundle.json","state":"https://pith.science/pith/L4XLWBYH5F337MHYE2EU3EC5OC/state.json","well_known_bundle":"https://pith.science/.well-known/pith/L4XLWBYH5F337MHYE2EU3EC5OC/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:L4XLWBYH5F337MHYE2EU3EC5OC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"899c24b35f8afaa03066c2dfea33a4253d73e0acb4c43f147e8d84e3595f9c03","cross_cats_sorted":["cs.CV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2025-02-25T01:25:49Z","title_canon_sha256":"f8740f534e2e1f4af1fa3f2fb00edc5de373a723b819ae7593482e38477cf107"},"schema_version":"1.0","source":{"id":"2502.17759","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.17759","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"arxiv_version","alias_value":"2502.17759v1","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.17759","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"pith_short_12","alias_value":"L4XLWBYH5F33","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"pith_short_16","alias_value":"L4XLWBYH5F337MHY","created_at":"2026-07-05T10:19:43Z"},{"alias_kind":"pith_short_8","alias_value":"L4XLWBYH","created_at":"2026-07-05T10:19:43Z"}],"graph_snapshots":[{"event_id":"sha256:9d0bad71c027c36694ee344996132c77b115604a3c93831075c059df8caa2741","target":"graph","created_at":"2026-07-05T10:19:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2502.17759/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Continuous monitoring and in-situ assessment of microvascular connectivity have significant implications for culturing vascularized organoids and optimizing the therapeutic strategies. However, commonly used methods for vascular connectivity assessment heavily rely on fluorescent labels that may either raise biocompatibility concerns or interrupt the normal cell growth process. To address this issue, a Vessel Connectivity Network (VC-Net) was developed for label-free assessment of vascular connectivity. To validate the VC-Net, microvascular networks (MVNs) were cultured in vitro and their micr","authors_text":"Chen Han, Jie Gao, Liang Xu, Mingzhai Sun, Min Ye, Pengwu Song, Peng Yao, Qingdong Zhang, Ronald X. Xu, Ru Zhang, Shilu Zhu, Yang Zhang, Zhiyuan Zheng","cross_cats":["cs.CV"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2025-02-25T01:25:49Z","title":"Label-free Prediction of Vascular Connectivity in Perfused Microvascular Networks in vitro"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.17759","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8d0d7a4b1d6941b854ec731805251237cd56ba5ea29bcd9cea9d70312da95ad6","target":"record","created_at":"2026-07-05T10:19:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"899c24b35f8afaa03066c2dfea33a4253d73e0acb4c43f147e8d84e3595f9c03","cross_cats_sorted":["cs.CV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2025-02-25T01:25:49Z","title_canon_sha256":"f8740f534e2e1f4af1fa3f2fb00edc5de373a723b819ae7593482e38477cf107"},"schema_version":"1.0","source":{"id":"2502.17759","kind":"arxiv","version":1}},"canonical_sha256":"5f2ebb0707e977bfb0f826894d905d70babf0ec9a16089a166ef59a6d436d0a3","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"5f2ebb0707e977bfb0f826894d905d70babf0ec9a16089a166ef59a6d436d0a3","first_computed_at":"2026-07-05T10:19:43.553945Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:19:43.553945Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"3hQlYivddQh5emF2xGZu3y7e74MxQShrjFnZb9/Ed1hWjYJm60DVmYjp5nq6YnzoomdoXDDUHKf1OUKuM1gEDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T10:19:43.554455Z","signed_message":"canonical_sha256_bytes"},"source_id":"2502.17759","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8d0d7a4b1d6941b854ec731805251237cd56ba5ea29bcd9cea9d70312da95ad6","sha256:9d0bad71c027c36694ee344996132c77b115604a3c93831075c059df8caa2741"],"state_sha256":"9216a391726bc0c8a73aec29dc16836699948198ad8826cd4a855fbcf10ac420"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0A/5vLLNCBsBawUwnAS9hrPyH6MIZzDk5G633CpugilGuxavydcuI4o9rRz2NrOCufr0jwXYesG2oL9l1OoICw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-06T11:29:58.735632Z","bundle_sha256":"96929a79ac77c9db6086c973eaa1481bce86a1522264182a7970da5126f70002"}}