{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:LA5JZMDTYUX6WNJF7ZZFWVW6U3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1a8a0aee6ff1effe9b67fbd98cd8956c8354dd124477a7366e095f963f0861ae","cross_cats_sorted":["cs.CL","cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.AI","submitted_at":"2024-06-13T04:23:35Z","title_canon_sha256":"551b0fd7950c74735f8b6b123e0b947703048c12f7342dae60c83cf062af36e1"},"schema_version":"1.0","source":{"id":"2406.10292","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2406.10292","created_at":"2026-07-05T10:25:07Z"},{"alias_kind":"arxiv_version","alias_value":"2406.10292v3","created_at":"2026-07-05T10:25:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2406.10292","created_at":"2026-07-05T10:25:07Z"},{"alias_kind":"pith_short_12","alias_value":"LA5JZMDTYUX6","created_at":"2026-07-05T10:25:07Z"},{"alias_kind":"pith_short_16","alias_value":"LA5JZMDTYUX6WNJF","created_at":"2026-07-05T10:25:07Z"},{"alias_kind":"pith_short_8","alias_value":"LA5JZMDT","created_at":"2026-07-05T10:25:07Z"}],"graph_snapshots":[{"event_id":"sha256:557f36f15dda99143356041eabe2e55af7f091a8a3113ba357751abb42de404a","target":"graph","created_at":"2026-07-05T10:25:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2406.10292/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Background The cost of drug discovery and development is substantial, with clinical trial outcomes playing a critical role in regulatory approval and patient care. However, access to large-scale, high-quality clinical trial outcome data remains limited, hindering advancements in predictive modeling and evidence-based decision-making.\n  Methods We present the Clinical Trial Outcome (CTO) benchmark, a fully reproducible, large-scale repository encompassing approximately 125,000 drug and biologics trials. CTO integrates large language model (LLM) interpretations of publications, trial phase progr","authors_text":"Chufan Gao, Jathurshan Pradeepkumar, Jimeng Sun, Shivashankar Thati, Trisha Das","cross_cats":["cs.CL","cs.LG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.AI","submitted_at":"2024-06-13T04:23:35Z","title":"Automatically Labeling Clinical Trial Outcomes: A Large-Scale Benchmark for Drug Development"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2406.10292","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e483d5586228cfc7c2141182c3688a59d2c014dda31ee52a8d5b468424b43d48","target":"record","created_at":"2026-07-05T10:25:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1a8a0aee6ff1effe9b67fbd98cd8956c8354dd124477a7366e095f963f0861ae","cross_cats_sorted":["cs.CL","cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.AI","submitted_at":"2024-06-13T04:23:35Z","title_canon_sha256":"551b0fd7950c74735f8b6b123e0b947703048c12f7342dae60c83cf062af36e1"},"schema_version":"1.0","source":{"id":"2406.10292","kind":"arxiv","version":3}},"canonical_sha256":"583a9cb073c52feb3525fe725b56dea6f90aa5f881dbabd2dcef717b94be79fe","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"583a9cb073c52feb3525fe725b56dea6f90aa5f881dbabd2dcef717b94be79fe","first_computed_at":"2026-07-05T10:25:07.222995Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:25:07.222995Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"rACl0KLYXRSEP96Z/ZvalQget6hLoGnnuf4ivER/OAjAwi/rhRQf4efNJdOwKKZ4c8jIgGw5ZsKSFjSF0qlzAQ==","signature_status":"signed_v1","signed_at":"2026-07-05T10:25:07.223481Z","signed_message":"canonical_sha256_bytes"},"source_id":"2406.10292","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e483d5586228cfc7c2141182c3688a59d2c014dda31ee52a8d5b468424b43d48","sha256:557f36f15dda99143356041eabe2e55af7f091a8a3113ba357751abb42de404a"],"state_sha256":"a98a51b358a5eb937f13eaa21446b48786d46296e20791700ae49a0fa03c0ae0"}