{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:LPCRFT54Y2SD2SQSJKDCLFTMTZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"69a3e708944cb0a91371505bbc697a71d11602c3554eb4f8e77949128bd4dd6f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2015-09-28T15:31:16Z","title_canon_sha256":"c677f11e0f1e244ce5792a2e08914a717c0e1a12fb6449864de4d37850e83f73"},"schema_version":"1.0","source":{"id":"1509.08359","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.08359","created_at":"2026-05-18T01:31:54Z"},{"alias_kind":"arxiv_version","alias_value":"1509.08359v1","created_at":"2026-05-18T01:31:54Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.08359","created_at":"2026-05-18T01:31:54Z"},{"alias_kind":"pith_short_12","alias_value":"LPCRFT54Y2SD","created_at":"2026-05-18T12:29:29Z"},{"alias_kind":"pith_short_16","alias_value":"LPCRFT54Y2SD2SQS","created_at":"2026-05-18T12:29:29Z"},{"alias_kind":"pith_short_8","alias_value":"LPCRFT54","created_at":"2026-05-18T12:29:29Z"}],"graph_snapshots":[{"event_id":"sha256:05aac7bd0f531b2e73c051b27165ec57bb90d4cf648106f74edfa2488734ee36","target":"graph","created_at":"2026-05-18T01:31:54Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Structural magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients. The formation of these lesions is a complex process involving inflammation, tissue damage, and tissue repair, all of which are visible on MRI. Here we characterize the lesion formation process on longitudinal, multi-sequence structural MRI from 34 MS patients and relate the longitudinal changes we observe within lesions to therapeutic interventions. In this article, we first outline a pipeline to extract voxel level, multi-sequence longitudinal profiles from four MRI seq","authors_text":"Ani Eloyan, Blake E. Dewey, Ciprian M. Crainiceanu, Daniel S. Reich, Elizabeth M. Sweeney, John Muschelli, Matthew K. Schindler, Russell T. Shinohara","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2015-09-28T15:31:16Z","title":"Relating multi-sequence longitudinal intensity profiles and clinical covariates in new multiple sclerosis lesions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.08359","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:7b5a3362ea0ef5128cbe68d062e747e2de8e0c3260ca1da1acd3f1e7ec23277b","target":"record","created_at":"2026-05-18T01:31:54Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"69a3e708944cb0a91371505bbc697a71d11602c3554eb4f8e77949128bd4dd6f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2015-09-28T15:31:16Z","title_canon_sha256":"c677f11e0f1e244ce5792a2e08914a717c0e1a12fb6449864de4d37850e83f73"},"schema_version":"1.0","source":{"id":"1509.08359","kind":"arxiv","version":1}},"canonical_sha256":"5bc512cfbcc6a43d4a124a8625966c9e7075d1fbc562dac34d63775ef8f6c6e7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"5bc512cfbcc6a43d4a124a8625966c9e7075d1fbc562dac34d63775ef8f6c6e7","first_computed_at":"2026-05-18T01:31:54.077129Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:31:54.077129Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"rWAuOmx4zF0GSC/yxYySBUK8WPKJVaODU3sGJ/6c1jXn+PLcfPVzOiCSJbwy69yO3187TapqIHA0nv3TsVPRCg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:31:54.077818Z","signed_message":"canonical_sha256_bytes"},"source_id":"1509.08359","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:7b5a3362ea0ef5128cbe68d062e747e2de8e0c3260ca1da1acd3f1e7ec23277b","sha256:05aac7bd0f531b2e73c051b27165ec57bb90d4cf648106f74edfa2488734ee36"],"state_sha256":"af4bafbb03c2d7d066d9572424fd2d60c770ccabc2b6550c37d051d74b2f11ca"}