{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:LQMUNRRVSPGVHISKCMEISVLOMN","short_pith_number":"pith:LQMUNRRV","schema_version":"1.0","canonical_sha256":"5c1946c63593cd53a24a130889556e63540158dd8ccea87d13fd5e642a1aa9fe","source":{"kind":"arxiv","id":"1509.03693","version":1},"attestation_state":"computed","paper":{"title":"Integrated probability of coronary heart disease subject to the -308 tumor necrosis factor-alpha SNP: a Bayesian meta-analysis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"C. Sofia Carvalho","submitted_at":"2015-09-12T02:01:37Z","abstract_excerpt":"We present a meta-analysis of independent studies on the potential implication in the occurrence of coronary heart disease (CHD) of the single-nucleotide polymorphism (SNP) at the -308 position of the tumor necrosis factor alpha (TNF-alpha) gene. We use Bayesian analysis to integrate independent data sets and to infer statistically robust measurements of correlation. Bayesian hypothesis testing indicates that there is no preference for the hypothesis that the -308 TNF-alpha SNP is related to the occurrence of CHD, in the Caucasian or in the Asian population, over the null hypothesis. As a meas"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1509.03693","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-09-12T02:01:37Z","cross_cats_sorted":[],"title_canon_sha256":"28b9788cee236c94222007386c84c3ffb84d8e2b061855554dac41a5552b65ff","abstract_canon_sha256":"029003afaa4a3df72d28fb7b66f9cf246ec2333f29b7f224503d0c4befbc1a92"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:32:50.093662Z","signature_b64":"3saDNci+K2/WpV6T2THmIDRwxz0I9f7FGAPZ+PVLzpDHHTEfyiUpjyIrd5WKNg19MbjHPFZIq71lJCnU/fNCCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5c1946c63593cd53a24a130889556e63540158dd8ccea87d13fd5e642a1aa9fe","last_reissued_at":"2026-05-18T01:32:50.093035Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:32:50.093035Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Integrated probability of coronary heart disease subject to the -308 tumor necrosis factor-alpha SNP: a Bayesian meta-analysis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"C. Sofia Carvalho","submitted_at":"2015-09-12T02:01:37Z","abstract_excerpt":"We present a meta-analysis of independent studies on the potential implication in the occurrence of coronary heart disease (CHD) of the single-nucleotide polymorphism (SNP) at the -308 position of the tumor necrosis factor alpha (TNF-alpha) gene. We use Bayesian analysis to integrate independent data sets and to infer statistically robust measurements of correlation. Bayesian hypothesis testing indicates that there is no preference for the hypothesis that the -308 TNF-alpha SNP is related to the occurrence of CHD, in the Caucasian or in the Asian population, over the null hypothesis. As a meas"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.03693","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1509.03693","created_at":"2026-05-18T01:32:50.093128+00:00"},{"alias_kind":"arxiv_version","alias_value":"1509.03693v1","created_at":"2026-05-18T01:32:50.093128+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.03693","created_at":"2026-05-18T01:32:50.093128+00:00"},{"alias_kind":"pith_short_12","alias_value":"LQMUNRRVSPGV","created_at":"2026-05-18T12:29:29.992203+00:00"},{"alias_kind":"pith_short_16","alias_value":"LQMUNRRVSPGVHISK","created_at":"2026-05-18T12:29:29.992203+00:00"},{"alias_kind":"pith_short_8","alias_value":"LQMUNRRV","created_at":"2026-05-18T12:29:29.992203+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN","json":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN.json","graph_json":"https://pith.science/api/pith-number/LQMUNRRVSPGVHISKCMEISVLOMN/graph.json","events_json":"https://pith.science/api/pith-number/LQMUNRRVSPGVHISKCMEISVLOMN/events.json","paper":"https://pith.science/paper/LQMUNRRV"},"agent_actions":{"view_html":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN","download_json":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN.json","view_paper":"https://pith.science/paper/LQMUNRRV","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1509.03693&json=true","fetch_graph":"https://pith.science/api/pith-number/LQMUNRRVSPGVHISKCMEISVLOMN/graph.json","fetch_events":"https://pith.science/api/pith-number/LQMUNRRVSPGVHISKCMEISVLOMN/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN/action/timestamp_anchor","attest_storage":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN/action/storage_attestation","attest_author":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN/action/author_attestation","sign_citation":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN/action/citation_signature","submit_replication":"https://pith.science/pith/LQMUNRRVSPGVHISKCMEISVLOMN/action/replication_record"}},"created_at":"2026-05-18T01:32:50.093128+00:00","updated_at":"2026-05-18T01:32:50.093128+00:00"}