{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2023:LRPBTKDA6KSPXXNZRRFMKLENWX","short_pith_number":"pith:LRPBTKDA","canonical_record":{"source":{"id":"2311.03569","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-11-06T22:12:54Z","cross_cats_sorted":["q-bio.PE","q-bio.TO"],"title_canon_sha256":"f0fb2f6b2297fcbd01141227fdf2d511d28528e22dca21fa0f9b53d1ecc54b89","abstract_canon_sha256":"fbada57806e5f68080ae29f3ec4b7d821e0b4b879e937bd91eafd28e65a181bb"},"schema_version":"1.0"},"canonical_sha256":"5c5e19a860f2a4fbddb98c4ac52c8db5f2107d8c8ee7e99c8770feac408fb4be","source":{"kind":"arxiv","id":"2311.03569","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2311.03569","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"arxiv_version","alias_value":"2311.03569v1","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2311.03569","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"pith_short_12","alias_value":"LRPBTKDA6KSP","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"pith_short_16","alias_value":"LRPBTKDA6KSPXXNZ","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"pith_short_8","alias_value":"LRPBTKDA","created_at":"2026-07-05T07:10:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2023:LRPBTKDA6KSPXXNZRRFMKLENWX","target":"record","payload":{"canonical_record":{"source":{"id":"2311.03569","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-11-06T22:12:54Z","cross_cats_sorted":["q-bio.PE","q-bio.TO"],"title_canon_sha256":"f0fb2f6b2297fcbd01141227fdf2d511d28528e22dca21fa0f9b53d1ecc54b89","abstract_canon_sha256":"fbada57806e5f68080ae29f3ec4b7d821e0b4b879e937bd91eafd28e65a181bb"},"schema_version":"1.0"},"canonical_sha256":"5c5e19a860f2a4fbddb98c4ac52c8db5f2107d8c8ee7e99c8770feac408fb4be","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:10:00.317423Z","signature_b64":"kekWYM6LFuZx79whTU3xfksOIjzrwkjZQusN4Hfe2SfXLXLvce3ALyh9We7ncrbOFDpYrBRE99xzC3MIRpXJCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5c5e19a860f2a4fbddb98c4ac52c8db5f2107d8c8ee7e99c8770feac408fb4be","last_reissued_at":"2026-07-05T07:10:00.316809Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:10:00.316809Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2311.03569","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:10:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xYAxTCVykr00rDIScV9VgFxwNr/k2ZYOC20KlfoL+9QU+AM60owgS2qC1A0AWUXqlNOyGlndiR3WCeh1dIAhCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-01T02:10:41.342201Z"},"content_sha256":"f2d10b2c34b597544a9c9ec06e1cbdeea5d6e96752b63bc55da7dbcf2279a6e5","schema_version":"1.0","event_id":"sha256:f2d10b2c34b597544a9c9ec06e1cbdeea5d6e96752b63bc55da7dbcf2279a6e5"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2023:LRPBTKDA6KSPXXNZRRFMKLENWX","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A seven-step guide to spatial, agent-based modelling of tumour evolution","license":"http://creativecommons.org/licenses/by-sa/4.0/","headline":"","cross_cats":["q-bio.PE","q-bio.TO"],"primary_cat":"q-bio.QM","authors_text":"Blair Colyer, David Basanta, Maciej Bak, Robert Noble","submitted_at":"2023-11-06T22:12:54Z","abstract_excerpt":"Spatial agent-based models are increasingly used to investigate the evolution of solid tumours subject to localised cell-cell interactions and microenvironmental heterogeneity. Here we present a non-technical step by step guide to developing such a model from first principles, aimed at both aspiring modellers and other biologists and oncologists who wish to understand the assumptions and limitations of this approach. Stressing the importance of tailoring the model structure to that of the biological system, we describe methods of increasing complexity, from the basic Eden growth model up to of"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2311.03569","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2311.03569/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:10:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1J8RWTFMHZlTZn4BmugSSDVOABskc5hARwuhk+PnLJvmkBGCRsLPdzmUtYI/upZjeDeenQxQUKISqzvcjSR6AQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-01T02:10:41.342489Z"},"content_sha256":"e1b4604e09db9dd4f7fb2034a07935db67ac8ee68dc9b3fb0d1309cf67d218a5","schema_version":"1.0","event_id":"sha256:e1b4604e09db9dd4f7fb2034a07935db67ac8ee68dc9b3fb0d1309cf67d218a5"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/LRPBTKDA6KSPXXNZRRFMKLENWX/bundle.json","state_url":"https://pith.science/pith/LRPBTKDA6KSPXXNZRRFMKLENWX/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/LRPBTKDA6KSPXXNZRRFMKLENWX/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-01T02:10:41Z","links":{"resolver":"https://pith.science/pith/LRPBTKDA6KSPXXNZRRFMKLENWX","bundle":"https://pith.science/pith/LRPBTKDA6KSPXXNZRRFMKLENWX/bundle.json","state":"https://pith.science/pith/LRPBTKDA6KSPXXNZRRFMKLENWX/state.json","well_known_bundle":"https://pith.science/.well-known/pith/LRPBTKDA6KSPXXNZRRFMKLENWX/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:LRPBTKDA6KSPXXNZRRFMKLENWX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fbada57806e5f68080ae29f3ec4b7d821e0b4b879e937bd91eafd28e65a181bb","cross_cats_sorted":["q-bio.PE","q-bio.TO"],"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-11-06T22:12:54Z","title_canon_sha256":"f0fb2f6b2297fcbd01141227fdf2d511d28528e22dca21fa0f9b53d1ecc54b89"},"schema_version":"1.0","source":{"id":"2311.03569","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2311.03569","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"arxiv_version","alias_value":"2311.03569v1","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2311.03569","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"pith_short_12","alias_value":"LRPBTKDA6KSP","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"pith_short_16","alias_value":"LRPBTKDA6KSPXXNZ","created_at":"2026-07-05T07:10:00Z"},{"alias_kind":"pith_short_8","alias_value":"LRPBTKDA","created_at":"2026-07-05T07:10:00Z"}],"graph_snapshots":[{"event_id":"sha256:e1b4604e09db9dd4f7fb2034a07935db67ac8ee68dc9b3fb0d1309cf67d218a5","target":"graph","created_at":"2026-07-05T07:10:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2311.03569/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Spatial agent-based models are increasingly used to investigate the evolution of solid tumours subject to localised cell-cell interactions and microenvironmental heterogeneity. Here we present a non-technical step by step guide to developing such a model from first principles, aimed at both aspiring modellers and other biologists and oncologists who wish to understand the assumptions and limitations of this approach. Stressing the importance of tailoring the model structure to that of the biological system, we describe methods of increasing complexity, from the basic Eden growth model up to of","authors_text":"Blair Colyer, David Basanta, Maciej Bak, Robert Noble","cross_cats":["q-bio.PE","q-bio.TO"],"headline":"","license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-11-06T22:12:54Z","title":"A seven-step guide to spatial, agent-based modelling of tumour evolution"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2311.03569","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f2d10b2c34b597544a9c9ec06e1cbdeea5d6e96752b63bc55da7dbcf2279a6e5","target":"record","created_at":"2026-07-05T07:10:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fbada57806e5f68080ae29f3ec4b7d821e0b4b879e937bd91eafd28e65a181bb","cross_cats_sorted":["q-bio.PE","q-bio.TO"],"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-11-06T22:12:54Z","title_canon_sha256":"f0fb2f6b2297fcbd01141227fdf2d511d28528e22dca21fa0f9b53d1ecc54b89"},"schema_version":"1.0","source":{"id":"2311.03569","kind":"arxiv","version":1}},"canonical_sha256":"5c5e19a860f2a4fbddb98c4ac52c8db5f2107d8c8ee7e99c8770feac408fb4be","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"5c5e19a860f2a4fbddb98c4ac52c8db5f2107d8c8ee7e99c8770feac408fb4be","first_computed_at":"2026-07-05T07:10:00.316809Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:10:00.316809Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"kekWYM6LFuZx79whTU3xfksOIjzrwkjZQusN4Hfe2SfXLXLvce3ALyh9We7ncrbOFDpYrBRE99xzC3MIRpXJCA==","signature_status":"signed_v1","signed_at":"2026-07-05T07:10:00.317423Z","signed_message":"canonical_sha256_bytes"},"source_id":"2311.03569","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f2d10b2c34b597544a9c9ec06e1cbdeea5d6e96752b63bc55da7dbcf2279a6e5","sha256:e1b4604e09db9dd4f7fb2034a07935db67ac8ee68dc9b3fb0d1309cf67d218a5"],"state_sha256":"ea515f72897d9a3d7d4f2e552be1d34c2c0061135624f5d7e6522697a035e4f9"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TvNT4B6EcLWyjG9wZ19L7j1HqgS6ZT8AqGQqGRXib1LzH6cTz6P6NnrBZKnVmFIxNAzlJNv8F3sbHoTKcSyCDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-01T02:10:41.346770Z","bundle_sha256":"3e51cbe68af210d5e70539f0580f985c32db51b9fe13b4fa6bddaf53718c087f"}}