{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:LVXC4XVTK5ZKZHQYJQLJBF2VXH","short_pith_number":"pith:LVXC4XVT","canonical_record":{"source":{"id":"1701.02943","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-01-11T12:13:57Z","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"title_canon_sha256":"d12cbe854e8b6e3023c921a6f84f9a539d3d4d23fa652c0a793c3dd4d2d15521","abstract_canon_sha256":"46aca5f4ba90cba0e062bd789eb62e02f9ee9031b9d5b3b2b1ff8c4a1db56707"},"schema_version":"1.0"},"canonical_sha256":"5d6e2e5eb35772ac9e184c16909755b9f1de1abe0931d74419a97e4c6a6fe9a1","source":{"kind":"arxiv","id":"1701.02943","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1701.02943","created_at":"2026-05-18T00:43:55Z"},{"alias_kind":"arxiv_version","alias_value":"1701.02943v1","created_at":"2026-05-18T00:43:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.02943","created_at":"2026-05-18T00:43:55Z"},{"alias_kind":"pith_short_12","alias_value":"LVXC4XVTK5ZK","created_at":"2026-05-18T12:31:28Z"},{"alias_kind":"pith_short_16","alias_value":"LVXC4XVTK5ZKZHQY","created_at":"2026-05-18T12:31:28Z"},{"alias_kind":"pith_short_8","alias_value":"LVXC4XVT","created_at":"2026-05-18T12:31:28Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:LVXC4XVTK5ZKZHQYJQLJBF2VXH","target":"record","payload":{"canonical_record":{"source":{"id":"1701.02943","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-01-11T12:13:57Z","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"title_canon_sha256":"d12cbe854e8b6e3023c921a6f84f9a539d3d4d23fa652c0a793c3dd4d2d15521","abstract_canon_sha256":"46aca5f4ba90cba0e062bd789eb62e02f9ee9031b9d5b3b2b1ff8c4a1db56707"},"schema_version":"1.0"},"canonical_sha256":"5d6e2e5eb35772ac9e184c16909755b9f1de1abe0931d74419a97e4c6a6fe9a1","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:43:55.703746Z","signature_b64":"k8cYlj1f/SYaOZvkyuARldqy9+ntLDbjKrNdQQiSeQ3m2uBxvawdrJKEHIxh8JcSp32svBnaj+4Prrpp6J7RDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5d6e2e5eb35772ac9e184c16909755b9f1de1abe0931d74419a97e4c6a6fe9a1","last_reissued_at":"2026-05-18T00:43:55.703171Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:43:55.703171Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1701.02943","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:43:55Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lGNKD0BuB+goMG1iLC9xFN1Sobn0A9LfjbZRiNtgdGgiUSFH6OITo197kfx2P+r5Tp3h5/kLrbgo17EqJItkAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-07T09:17:27.425933Z"},"content_sha256":"f192598750325e3d0b70699f66ade366d25acce3e224a2fcfaaf8d2b6d38ce3d","schema_version":"1.0","event_id":"sha256:f192598750325e3d0b70699f66ade366d25acce3e224a2fcfaaf8d2b6d38ce3d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:LVXC4XVTK5ZKZHQYJQLJBF2VXH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Entropy facilitated active transport","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.soft","physics.bio-ph"],"primary_cat":"q-bio.BM","authors_text":"A. Lervik, D. Bedeaux, J. M. Rubi, S. Kjelstrup","submitted_at":"2017-01-11T12:13:57Z","abstract_excerpt":"We show how active transport of ions can be interpreted as an entropy facilitated process. In this interpretation, the pore geometry through which substrates are transported can give rise to a driving force. This gives a direct link between the geometry and the changes in Gibbs energy required. Quantifying the size of this effect for several proteins we find that the entropic contribution from the pore geometry is significant and we discuss how the effect can be used to interpret variations in the affinity at the binding site."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.02943","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:43:55Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JS5L1Qj2wX4iaE8DOk9p9j0PCJaJbXTLlRNY5ghtfc/Nc4jluqTBl5hlCisi1GwL9s9VCH+9XAHdzI0UdqctAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-07T09:17:27.426631Z"},"content_sha256":"6415233e3066ce59f131d684a010dd89c6cd7c0af22100695d4c9cee3fc44a94","schema_version":"1.0","event_id":"sha256:6415233e3066ce59f131d684a010dd89c6cd7c0af22100695d4c9cee3fc44a94"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/LVXC4XVTK5ZKZHQYJQLJBF2VXH/bundle.json","state_url":"https://pith.science/pith/LVXC4XVTK5ZKZHQYJQLJBF2VXH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/LVXC4XVTK5ZKZHQYJQLJBF2VXH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-07T09:17:27Z","links":{"resolver":"https://pith.science/pith/LVXC4XVTK5ZKZHQYJQLJBF2VXH","bundle":"https://pith.science/pith/LVXC4XVTK5ZKZHQYJQLJBF2VXH/bundle.json","state":"https://pith.science/pith/LVXC4XVTK5ZKZHQYJQLJBF2VXH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/LVXC4XVTK5ZKZHQYJQLJBF2VXH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:LVXC4XVTK5ZKZHQYJQLJBF2VXH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"46aca5f4ba90cba0e062bd789eb62e02f9ee9031b9d5b3b2b1ff8c4a1db56707","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-01-11T12:13:57Z","title_canon_sha256":"d12cbe854e8b6e3023c921a6f84f9a539d3d4d23fa652c0a793c3dd4d2d15521"},"schema_version":"1.0","source":{"id":"1701.02943","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1701.02943","created_at":"2026-05-18T00:43:55Z"},{"alias_kind":"arxiv_version","alias_value":"1701.02943v1","created_at":"2026-05-18T00:43:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.02943","created_at":"2026-05-18T00:43:55Z"},{"alias_kind":"pith_short_12","alias_value":"LVXC4XVTK5ZK","created_at":"2026-05-18T12:31:28Z"},{"alias_kind":"pith_short_16","alias_value":"LVXC4XVTK5ZKZHQY","created_at":"2026-05-18T12:31:28Z"},{"alias_kind":"pith_short_8","alias_value":"LVXC4XVT","created_at":"2026-05-18T12:31:28Z"}],"graph_snapshots":[{"event_id":"sha256:6415233e3066ce59f131d684a010dd89c6cd7c0af22100695d4c9cee3fc44a94","target":"graph","created_at":"2026-05-18T00:43:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We show how active transport of ions can be interpreted as an entropy facilitated process. In this interpretation, the pore geometry through which substrates are transported can give rise to a driving force. This gives a direct link between the geometry and the changes in Gibbs energy required. Quantifying the size of this effect for several proteins we find that the entropic contribution from the pore geometry is significant and we discuss how the effect can be used to interpret variations in the affinity at the binding site.","authors_text":"A. Lervik, D. Bedeaux, J. M. Rubi, S. Kjelstrup","cross_cats":["cond-mat.soft","physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-01-11T12:13:57Z","title":"Entropy facilitated active transport"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.02943","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f192598750325e3d0b70699f66ade366d25acce3e224a2fcfaaf8d2b6d38ce3d","target":"record","created_at":"2026-05-18T00:43:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"46aca5f4ba90cba0e062bd789eb62e02f9ee9031b9d5b3b2b1ff8c4a1db56707","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-01-11T12:13:57Z","title_canon_sha256":"d12cbe854e8b6e3023c921a6f84f9a539d3d4d23fa652c0a793c3dd4d2d15521"},"schema_version":"1.0","source":{"id":"1701.02943","kind":"arxiv","version":1}},"canonical_sha256":"5d6e2e5eb35772ac9e184c16909755b9f1de1abe0931d74419a97e4c6a6fe9a1","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"5d6e2e5eb35772ac9e184c16909755b9f1de1abe0931d74419a97e4c6a6fe9a1","first_computed_at":"2026-05-18T00:43:55.703171Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:43:55.703171Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"k8cYlj1f/SYaOZvkyuARldqy9+ntLDbjKrNdQQiSeQ3m2uBxvawdrJKEHIxh8JcSp32svBnaj+4Prrpp6J7RDA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:43:55.703746Z","signed_message":"canonical_sha256_bytes"},"source_id":"1701.02943","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f192598750325e3d0b70699f66ade366d25acce3e224a2fcfaaf8d2b6d38ce3d","sha256:6415233e3066ce59f131d684a010dd89c6cd7c0af22100695d4c9cee3fc44a94"],"state_sha256":"43c43de3d0058ae3b71d594893f5f80420e638edb49f189ce674c50ad5fc2fab"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"77vLgKlfGWbQTlecSXtdSGrdTdQEf49pn7Z6JsafAoKJFGtKymDdP1aeK03tzLVMwF0vvyxorO3TJvMHlA5yDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-07T09:17:27.429744Z","bundle_sha256":"5e8bb5386a79104ea52e975cecb0c06081d6c639b0d059e3aa77d3068bc8006e"}}