{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:LYCPSQSEMLN2QFJZJOMLZELUJU","short_pith_number":"pith:LYCPSQSE","canonical_record":{"source":{"id":"2107.14770","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.chem-ph","submitted_at":"2021-07-30T17:24:23Z","cross_cats_sorted":["physics.bio-ph","physics.data-an","q-bio.BM","q-bio.QM"],"title_canon_sha256":"6f4a8b8bcaa657e55d5e4ff1fe7d7607b620478ab681943b1a724399fd8ba9c2","abstract_canon_sha256":"9427f2f47d63908891146dee5bca18fe3146d5421ccdb2e5660e42049c025917"},"schema_version":"1.0"},"canonical_sha256":"5e04f9424462dba815394b98bc91744d20081ab3e871a51785f0698e87d90c54","source":{"kind":"arxiv","id":"2107.14770","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2107.14770","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"arxiv_version","alias_value":"2107.14770v1","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2107.14770","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"pith_short_12","alias_value":"LYCPSQSEMLN2","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"pith_short_16","alias_value":"LYCPSQSEMLN2QFJZ","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"pith_short_8","alias_value":"LYCPSQSE","created_at":"2026-07-05T04:18:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:LYCPSQSEMLN2QFJZJOMLZELUJU","target":"record","payload":{"canonical_record":{"source":{"id":"2107.14770","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.chem-ph","submitted_at":"2021-07-30T17:24:23Z","cross_cats_sorted":["physics.bio-ph","physics.data-an","q-bio.BM","q-bio.QM"],"title_canon_sha256":"6f4a8b8bcaa657e55d5e4ff1fe7d7607b620478ab681943b1a724399fd8ba9c2","abstract_canon_sha256":"9427f2f47d63908891146dee5bca18fe3146d5421ccdb2e5660e42049c025917"},"schema_version":"1.0"},"canonical_sha256":"5e04f9424462dba815394b98bc91744d20081ab3e871a51785f0698e87d90c54","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T04:18:00.794537Z","signature_b64":"Cs2rnCJtmyazgBnGaAA5G6mtExE/L339/4qYRLLa29rPnw0e3h+E9zuf0Ru/dvNgYT0kRVbCwMu+CAzsb4W8AQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"5e04f9424462dba815394b98bc91744d20081ab3e871a51785f0698e87d90c54","last_reissued_at":"2026-07-05T04:18:00.794027Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T04:18:00.794027Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2107.14770","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:18:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"MvYWxdKLU4gyLOV29i/ysO4pIxh9+RIOmZuymAwp2miGwO8kX/7dvdRYAwL+PVAKi4f0ntSx8SDOVpr5DypODg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-17T23:02:29.479367Z"},"content_sha256":"eaae6eaedc5c803a0ad2509d47e18a9bce6548954f1ee94272a6fd99a3238c2a","schema_version":"1.0","event_id":"sha256:eaae6eaedc5c803a0ad2509d47e18a9bce6548954f1ee94272a6fd99a3238c2a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:LYCPSQSEMLN2QFJZJOMLZELUJU","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Unraveling multi-state molecular dynamics in single-molecule FRET experiments- Part I: Theory of FRET-Lines","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.bio-ph","physics.data-an","q-bio.BM","q-bio.QM"],"primary_cat":"physics.chem-ph","authors_text":"Anders Barth, Claus A.M. Seidel, Hugo Sanabria, Oleg Opanasyuk, Stanislav Kalinin, Suren Felekyan, Thomas-Otavio Peulen","submitted_at":"2021-07-30T17:24:23Z","abstract_excerpt":"Conformational dynamics of biomolecules are of fundamental importance for their function. Single-molecule F\\\"orster Resonance Energy Transfer (smFRET) is a powerful approach to inform on the structure and the dynamics of labeled molecules. If the dynamics occur on the sub-millisecond timescale, capturing and quantifying conformational dynamics can be challenging by intensity-based smFRET. Multiparameter fluorescence detection (MFD) addresses this challenge by simultaneously registering intensities and fluorescence lifetimes. Together, the mean donor fluorescence lifetime and the fluorescence i"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2107.14770","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2107.14770/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:18:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NRB0dvjCdXgILYg2B1HJ460+B4de6GKojaaBPVGxz6t8JokAvQwT9ryBcYJl01MxzLddxTBGvOYQ3757mswBAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-17T23:02:29.479902Z"},"content_sha256":"7fe41428101802645d1b4e57e74b164c9d38dca71a3b19e0c38e75eefa832fd5","schema_version":"1.0","event_id":"sha256:7fe41428101802645d1b4e57e74b164c9d38dca71a3b19e0c38e75eefa832fd5"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/LYCPSQSEMLN2QFJZJOMLZELUJU/bundle.json","state_url":"https://pith.science/pith/LYCPSQSEMLN2QFJZJOMLZELUJU/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/LYCPSQSEMLN2QFJZJOMLZELUJU/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-17T23:02:29Z","links":{"resolver":"https://pith.science/pith/LYCPSQSEMLN2QFJZJOMLZELUJU","bundle":"https://pith.science/pith/LYCPSQSEMLN2QFJZJOMLZELUJU/bundle.json","state":"https://pith.science/pith/LYCPSQSEMLN2QFJZJOMLZELUJU/state.json","well_known_bundle":"https://pith.science/.well-known/pith/LYCPSQSEMLN2QFJZJOMLZELUJU/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:LYCPSQSEMLN2QFJZJOMLZELUJU","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9427f2f47d63908891146dee5bca18fe3146d5421ccdb2e5660e42049c025917","cross_cats_sorted":["physics.bio-ph","physics.data-an","q-bio.BM","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.chem-ph","submitted_at":"2021-07-30T17:24:23Z","title_canon_sha256":"6f4a8b8bcaa657e55d5e4ff1fe7d7607b620478ab681943b1a724399fd8ba9c2"},"schema_version":"1.0","source":{"id":"2107.14770","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2107.14770","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"arxiv_version","alias_value":"2107.14770v1","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2107.14770","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"pith_short_12","alias_value":"LYCPSQSEMLN2","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"pith_short_16","alias_value":"LYCPSQSEMLN2QFJZ","created_at":"2026-07-05T04:18:00Z"},{"alias_kind":"pith_short_8","alias_value":"LYCPSQSE","created_at":"2026-07-05T04:18:00Z"}],"graph_snapshots":[{"event_id":"sha256:7fe41428101802645d1b4e57e74b164c9d38dca71a3b19e0c38e75eefa832fd5","target":"graph","created_at":"2026-07-05T04:18:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2107.14770/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Conformational dynamics of biomolecules are of fundamental importance for their function. Single-molecule F\\\"orster Resonance Energy Transfer (smFRET) is a powerful approach to inform on the structure and the dynamics of labeled molecules. If the dynamics occur on the sub-millisecond timescale, capturing and quantifying conformational dynamics can be challenging by intensity-based smFRET. Multiparameter fluorescence detection (MFD) addresses this challenge by simultaneously registering intensities and fluorescence lifetimes. Together, the mean donor fluorescence lifetime and the fluorescence i","authors_text":"Anders Barth, Claus A.M. Seidel, Hugo Sanabria, Oleg Opanasyuk, Stanislav Kalinin, Suren Felekyan, Thomas-Otavio Peulen","cross_cats":["physics.bio-ph","physics.data-an","q-bio.BM","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.chem-ph","submitted_at":"2021-07-30T17:24:23Z","title":"Unraveling multi-state molecular dynamics in single-molecule FRET experiments- Part I: Theory of FRET-Lines"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2107.14770","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:eaae6eaedc5c803a0ad2509d47e18a9bce6548954f1ee94272a6fd99a3238c2a","target":"record","created_at":"2026-07-05T04:18:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9427f2f47d63908891146dee5bca18fe3146d5421ccdb2e5660e42049c025917","cross_cats_sorted":["physics.bio-ph","physics.data-an","q-bio.BM","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.chem-ph","submitted_at":"2021-07-30T17:24:23Z","title_canon_sha256":"6f4a8b8bcaa657e55d5e4ff1fe7d7607b620478ab681943b1a724399fd8ba9c2"},"schema_version":"1.0","source":{"id":"2107.14770","kind":"arxiv","version":1}},"canonical_sha256":"5e04f9424462dba815394b98bc91744d20081ab3e871a51785f0698e87d90c54","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"5e04f9424462dba815394b98bc91744d20081ab3e871a51785f0698e87d90c54","first_computed_at":"2026-07-05T04:18:00.794027Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T04:18:00.794027Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Cs2rnCJtmyazgBnGaAA5G6mtExE/L339/4qYRLLa29rPnw0e3h+E9zuf0Ru/dvNgYT0kRVbCwMu+CAzsb4W8AQ==","signature_status":"signed_v1","signed_at":"2026-07-05T04:18:00.794537Z","signed_message":"canonical_sha256_bytes"},"source_id":"2107.14770","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:eaae6eaedc5c803a0ad2509d47e18a9bce6548954f1ee94272a6fd99a3238c2a","sha256:7fe41428101802645d1b4e57e74b164c9d38dca71a3b19e0c38e75eefa832fd5"],"state_sha256":"88bf7d0eac534f9c87640e206f895ac2c7beb0ebb79215f242415456c1ce929e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"x4ZGXS7TMbRPYUmRrDj4iS/aYTmSpZAnot8emjIV4y1eGsimA94T/7YcgJy4bu7Ljd4VqM/Y2OMuKrRF5p3ZBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-17T23:02:29.484905Z","bundle_sha256":"ec4a801e238c61edbdb6b51a557ff933905ee8ce4e186b15ba3d968dc624d815"}}