{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:M3M5ZMFHLNNEYXZLYBEKL3BRNX","short_pith_number":"pith:M3M5ZMFH","canonical_record":{"source":{"id":"1312.3991","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2013-12-14T00:48:56Z","cross_cats_sorted":[],"title_canon_sha256":"23b29e2e2572d729d683680005084c2c5cffafec8e875f067c44578e205dbbde","abstract_canon_sha256":"66ce0c99f3d1367edbb9653e82cb0e923e3007f937f18ff08729050e182af47b"},"schema_version":"1.0"},"canonical_sha256":"66d9dcb0a75b5a4c5f2bc048a5ec316defbd246cda141f500d5931d31750c28b","source":{"kind":"arxiv","id":"1312.3991","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1312.3991","created_at":"2026-05-18T03:04:36Z"},{"alias_kind":"arxiv_version","alias_value":"1312.3991v1","created_at":"2026-05-18T03:04:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1312.3991","created_at":"2026-05-18T03:04:36Z"},{"alias_kind":"pith_short_12","alias_value":"M3M5ZMFHLNNE","created_at":"2026-05-18T12:27:51Z"},{"alias_kind":"pith_short_16","alias_value":"M3M5ZMFHLNNEYXZL","created_at":"2026-05-18T12:27:51Z"},{"alias_kind":"pith_short_8","alias_value":"M3M5ZMFH","created_at":"2026-05-18T12:27:51Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:M3M5ZMFHLNNEYXZLYBEKL3BRNX","target":"record","payload":{"canonical_record":{"source":{"id":"1312.3991","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2013-12-14T00:48:56Z","cross_cats_sorted":[],"title_canon_sha256":"23b29e2e2572d729d683680005084c2c5cffafec8e875f067c44578e205dbbde","abstract_canon_sha256":"66ce0c99f3d1367edbb9653e82cb0e923e3007f937f18ff08729050e182af47b"},"schema_version":"1.0"},"canonical_sha256":"66d9dcb0a75b5a4c5f2bc048a5ec316defbd246cda141f500d5931d31750c28b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:04:36.351660Z","signature_b64":"XHHfRPA3BG6Zn9fAK6By4xYjywD+qkivnZYzlvE4k24khYcxD5Swyv4fCuv7r9kDl03wPmJr7x2YLUcmHe65CQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"66d9dcb0a75b5a4c5f2bc048a5ec316defbd246cda141f500d5931d31750c28b","last_reissued_at":"2026-05-18T03:04:36.350787Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:04:36.350787Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1312.3991","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:04:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"P3uMN40z0Ys0vHf8dmA2fGzeDw0omth6bTb3Z8JFzjX11DIkHmI3kyjnpQdFRhzbPR00w2BX2NsqLGFuUC9YAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T07:58:35.613785Z"},"content_sha256":"1b4bec22a66dd27701810dffa7491248eb89a771d66ef0fd3a79ca351daab4de","schema_version":"1.0","event_id":"sha256:1b4bec22a66dd27701810dffa7491248eb89a771d66ef0fd3a79ca351daab4de"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:M3M5ZMFHLNNEYXZLYBEKL3BRNX","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Biological mechanism and identifiability of a class of stationary conductance model for Voltage-gated Ion channels","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.SC","authors_text":"Febe Francis, M\\'iriam R. Garc\\'ia, Oliver Mason, Richard H. Middleton","submitted_at":"2013-12-14T00:48:56Z","abstract_excerpt":"The physiology of voltage gated ion channels is complex and insights into their gating mechanism is incomplete. Their function is best represented by Markov models with relatively large number of distinct states that are connected by thermodynamically feasible transitions. On the other hand, popular models such as the one of Hodgkin and Huxley have empirical assumptions that are generally unrealistic. Experimental protocols often dictate the number of states in proposed Markov models, thus creating disagreements between various observations on the same channel. Here we aim to propose a limit t"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1312.3991","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:04:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WtLOSQcAWIElzGh8EgW+wHsVBH1wwJ81nNkkXZUa2vRgxQ+4z4lCuoJUvx41OscZf0H8GjBgKlHbzPuI4ekZBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T07:58:35.614464Z"},"content_sha256":"b54510145f2eeef75f9e121c425eda14f01c010b4fe69c7eb70052716c01e270","schema_version":"1.0","event_id":"sha256:b54510145f2eeef75f9e121c425eda14f01c010b4fe69c7eb70052716c01e270"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/M3M5ZMFHLNNEYXZLYBEKL3BRNX/bundle.json","state_url":"https://pith.science/pith/M3M5ZMFHLNNEYXZLYBEKL3BRNX/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/M3M5ZMFHLNNEYXZLYBEKL3BRNX/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T07:58:35Z","links":{"resolver":"https://pith.science/pith/M3M5ZMFHLNNEYXZLYBEKL3BRNX","bundle":"https://pith.science/pith/M3M5ZMFHLNNEYXZLYBEKL3BRNX/bundle.json","state":"https://pith.science/pith/M3M5ZMFHLNNEYXZLYBEKL3BRNX/state.json","well_known_bundle":"https://pith.science/.well-known/pith/M3M5ZMFHLNNEYXZLYBEKL3BRNX/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:M3M5ZMFHLNNEYXZLYBEKL3BRNX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"66ce0c99f3d1367edbb9653e82cb0e923e3007f937f18ff08729050e182af47b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2013-12-14T00:48:56Z","title_canon_sha256":"23b29e2e2572d729d683680005084c2c5cffafec8e875f067c44578e205dbbde"},"schema_version":"1.0","source":{"id":"1312.3991","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1312.3991","created_at":"2026-05-18T03:04:36Z"},{"alias_kind":"arxiv_version","alias_value":"1312.3991v1","created_at":"2026-05-18T03:04:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1312.3991","created_at":"2026-05-18T03:04:36Z"},{"alias_kind":"pith_short_12","alias_value":"M3M5ZMFHLNNE","created_at":"2026-05-18T12:27:51Z"},{"alias_kind":"pith_short_16","alias_value":"M3M5ZMFHLNNEYXZL","created_at":"2026-05-18T12:27:51Z"},{"alias_kind":"pith_short_8","alias_value":"M3M5ZMFH","created_at":"2026-05-18T12:27:51Z"}],"graph_snapshots":[{"event_id":"sha256:b54510145f2eeef75f9e121c425eda14f01c010b4fe69c7eb70052716c01e270","target":"graph","created_at":"2026-05-18T03:04:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The physiology of voltage gated ion channels is complex and insights into their gating mechanism is incomplete. Their function is best represented by Markov models with relatively large number of distinct states that are connected by thermodynamically feasible transitions. On the other hand, popular models such as the one of Hodgkin and Huxley have empirical assumptions that are generally unrealistic. Experimental protocols often dictate the number of states in proposed Markov models, thus creating disagreements between various observations on the same channel. Here we aim to propose a limit t","authors_text":"Febe Francis, M\\'iriam R. Garc\\'ia, Oliver Mason, Richard H. Middleton","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2013-12-14T00:48:56Z","title":"Biological mechanism and identifiability of a class of stationary conductance model for Voltage-gated Ion channels"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1312.3991","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1b4bec22a66dd27701810dffa7491248eb89a771d66ef0fd3a79ca351daab4de","target":"record","created_at":"2026-05-18T03:04:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"66ce0c99f3d1367edbb9653e82cb0e923e3007f937f18ff08729050e182af47b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2013-12-14T00:48:56Z","title_canon_sha256":"23b29e2e2572d729d683680005084c2c5cffafec8e875f067c44578e205dbbde"},"schema_version":"1.0","source":{"id":"1312.3991","kind":"arxiv","version":1}},"canonical_sha256":"66d9dcb0a75b5a4c5f2bc048a5ec316defbd246cda141f500d5931d31750c28b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"66d9dcb0a75b5a4c5f2bc048a5ec316defbd246cda141f500d5931d31750c28b","first_computed_at":"2026-05-18T03:04:36.350787Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:04:36.350787Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XHHfRPA3BG6Zn9fAK6By4xYjywD+qkivnZYzlvE4k24khYcxD5Swyv4fCuv7r9kDl03wPmJr7x2YLUcmHe65CQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:04:36.351660Z","signed_message":"canonical_sha256_bytes"},"source_id":"1312.3991","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1b4bec22a66dd27701810dffa7491248eb89a771d66ef0fd3a79ca351daab4de","sha256:b54510145f2eeef75f9e121c425eda14f01c010b4fe69c7eb70052716c01e270"],"state_sha256":"aba4544aa4837e78d202479260e2699ea9bbc8cd2f6c012226174b0eea5e7bb3"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZJdI2xHIEHYpkofLz7wqxY7mhEcaW1XCioD/LpeQDM+EdvyEBR2oWMntMsAehQdUMXo9xMl5/lnwEkafsGKxDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T07:58:35.618739Z","bundle_sha256":"788f024cc661e4e9681dbc8f118dce6f5d7b696d6f0b7c79276803277e70b057"}}