{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:M3TQCTFRU3Y7E27PA4P24Z2UIZ","short_pith_number":"pith:M3TQCTFR","canonical_record":{"source":{"id":"1607.07259","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2016-07-25T13:26:38Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"42c38ab13b5b1814297466b16666a07b76d9b0108af3b6c4a076e76d6795e178","abstract_canon_sha256":"499a13af02159ae21fc5153be95547362a4e14738d9bd73b2ceb2db02b1017e2"},"schema_version":"1.0"},"canonical_sha256":"66e7014cb1a6f1f26bef071fae6754465e2b6444a9e3282981a69721fec7d874","source":{"kind":"arxiv","id":"1607.07259","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1607.07259","created_at":"2026-05-18T01:10:34Z"},{"alias_kind":"arxiv_version","alias_value":"1607.07259v1","created_at":"2026-05-18T01:10:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1607.07259","created_at":"2026-05-18T01:10:34Z"},{"alias_kind":"pith_short_12","alias_value":"M3TQCTFRU3Y7","created_at":"2026-05-18T12:30:29Z"},{"alias_kind":"pith_short_16","alias_value":"M3TQCTFRU3Y7E27P","created_at":"2026-05-18T12:30:29Z"},{"alias_kind":"pith_short_8","alias_value":"M3TQCTFR","created_at":"2026-05-18T12:30:29Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:M3TQCTFRU3Y7E27PA4P24Z2UIZ","target":"record","payload":{"canonical_record":{"source":{"id":"1607.07259","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2016-07-25T13:26:38Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"42c38ab13b5b1814297466b16666a07b76d9b0108af3b6c4a076e76d6795e178","abstract_canon_sha256":"499a13af02159ae21fc5153be95547362a4e14738d9bd73b2ceb2db02b1017e2"},"schema_version":"1.0"},"canonical_sha256":"66e7014cb1a6f1f26bef071fae6754465e2b6444a9e3282981a69721fec7d874","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:10:34.379504Z","signature_b64":"SXuWnGiD19XLqdH1zq5NcvZ4OgPZAXNxWNcxlRA3rYOx4+rOJ6NAy2eZW72fp5Ppxvne7iq2CK6Klr7gptgWDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"66e7014cb1a6f1f26bef071fae6754465e2b6444a9e3282981a69721fec7d874","last_reissued_at":"2026-05-18T01:10:34.378991Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:10:34.378991Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1607.07259","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:10:34Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"C+enu08iEpVM4+/OI2Rz76OnLNU4q/paq2Y1xbFGu++Kg39hLw0QAgShX4U+RY1zWz/gzfEsV9OL2T+4JuqXCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-19T08:11:16.623797Z"},"content_sha256":"c4e67517bb55d5cb8daede89a281f38758d681b5f911ee770453f44af7900112","schema_version":"1.0","event_id":"sha256:c4e67517bb55d5cb8daede89a281f38758d681b5f911ee770453f44af7900112"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:M3TQCTFRU3Y7E27PA4P24Z2UIZ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Model-free immune therapy: A control approach to acute inflammation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"math.OC","authors_text":"C\\'edric Join, Judy Day, Michel Fliess, Ouassim Bara, Seddik M. Djouadi","submitted_at":"2016-07-25T13:26:38Z","abstract_excerpt":"Control of an inflammatory immune response is still an ongoing research. Here, a strategy consisting of manipulating a pro and anti-inflammatory mediator is considered. Already existing and promising model-based techniques suffer unfortunately from a most difficult calibration. This is due to the different types of inflammations and to the strong parameter variation between patients. This communication explores another route via the new model-free control and its corresponding \"intelligent\" controllers. A \"virtual\" patient, i.e., a mathematical model, is only employed for digital simulations. "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1607.07259","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:10:34Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"W5l2hV4I1CvgL42Dvp4uYDjWMsFXD70uRpRJS+1Ha0khH3DAj9fljawVkh/fAGLe2p18RkqZguZLTGB7lSpjBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-19T08:11:16.624529Z"},"content_sha256":"86fd9461e0fe6ee2790538afe2fe0b794e6b53487f21b47dfd39770f07782b66","schema_version":"1.0","event_id":"sha256:86fd9461e0fe6ee2790538afe2fe0b794e6b53487f21b47dfd39770f07782b66"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/M3TQCTFRU3Y7E27PA4P24Z2UIZ/bundle.json","state_url":"https://pith.science/pith/M3TQCTFRU3Y7E27PA4P24Z2UIZ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/M3TQCTFRU3Y7E27PA4P24Z2UIZ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-19T08:11:16Z","links":{"resolver":"https://pith.science/pith/M3TQCTFRU3Y7E27PA4P24Z2UIZ","bundle":"https://pith.science/pith/M3TQCTFRU3Y7E27PA4P24Z2UIZ/bundle.json","state":"https://pith.science/pith/M3TQCTFRU3Y7E27PA4P24Z2UIZ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/M3TQCTFRU3Y7E27PA4P24Z2UIZ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:M3TQCTFRU3Y7E27PA4P24Z2UIZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"499a13af02159ae21fc5153be95547362a4e14738d9bd73b2ceb2db02b1017e2","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2016-07-25T13:26:38Z","title_canon_sha256":"42c38ab13b5b1814297466b16666a07b76d9b0108af3b6c4a076e76d6795e178"},"schema_version":"1.0","source":{"id":"1607.07259","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1607.07259","created_at":"2026-05-18T01:10:34Z"},{"alias_kind":"arxiv_version","alias_value":"1607.07259v1","created_at":"2026-05-18T01:10:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1607.07259","created_at":"2026-05-18T01:10:34Z"},{"alias_kind":"pith_short_12","alias_value":"M3TQCTFRU3Y7","created_at":"2026-05-18T12:30:29Z"},{"alias_kind":"pith_short_16","alias_value":"M3TQCTFRU3Y7E27P","created_at":"2026-05-18T12:30:29Z"},{"alias_kind":"pith_short_8","alias_value":"M3TQCTFR","created_at":"2026-05-18T12:30:29Z"}],"graph_snapshots":[{"event_id":"sha256:86fd9461e0fe6ee2790538afe2fe0b794e6b53487f21b47dfd39770f07782b66","target":"graph","created_at":"2026-05-18T01:10:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Control of an inflammatory immune response is still an ongoing research. Here, a strategy consisting of manipulating a pro and anti-inflammatory mediator is considered. Already existing and promising model-based techniques suffer unfortunately from a most difficult calibration. This is due to the different types of inflammations and to the strong parameter variation between patients. This communication explores another route via the new model-free control and its corresponding \"intelligent\" controllers. A \"virtual\" patient, i.e., a mathematical model, is only employed for digital simulations. ","authors_text":"C\\'edric Join, Judy Day, Michel Fliess, Ouassim Bara, Seddik M. Djouadi","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2016-07-25T13:26:38Z","title":"Model-free immune therapy: A control approach to acute inflammation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1607.07259","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c4e67517bb55d5cb8daede89a281f38758d681b5f911ee770453f44af7900112","target":"record","created_at":"2026-05-18T01:10:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"499a13af02159ae21fc5153be95547362a4e14738d9bd73b2ceb2db02b1017e2","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2016-07-25T13:26:38Z","title_canon_sha256":"42c38ab13b5b1814297466b16666a07b76d9b0108af3b6c4a076e76d6795e178"},"schema_version":"1.0","source":{"id":"1607.07259","kind":"arxiv","version":1}},"canonical_sha256":"66e7014cb1a6f1f26bef071fae6754465e2b6444a9e3282981a69721fec7d874","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"66e7014cb1a6f1f26bef071fae6754465e2b6444a9e3282981a69721fec7d874","first_computed_at":"2026-05-18T01:10:34.378991Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:10:34.378991Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"SXuWnGiD19XLqdH1zq5NcvZ4OgPZAXNxWNcxlRA3rYOx4+rOJ6NAy2eZW72fp5Ppxvne7iq2CK6Klr7gptgWDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:10:34.379504Z","signed_message":"canonical_sha256_bytes"},"source_id":"1607.07259","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c4e67517bb55d5cb8daede89a281f38758d681b5f911ee770453f44af7900112","sha256:86fd9461e0fe6ee2790538afe2fe0b794e6b53487f21b47dfd39770f07782b66"],"state_sha256":"1d77af6d910293a772227c8dfb9cffae2a81d3456e02ae21cd6b4758942bd46d"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ubTwge9mpFw5fe6yv660UD50rBB7N5zMUlbFwYl8OCYE+Mtlt0l5vxpZpKxT5qeL4HI4FdBzlseG1mDL7yrsAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-19T08:11:16.627195Z","bundle_sha256":"463f51ebdcdd882580e47f5c7e7d506c040842a0bc4133f3294cf44cf1588283"}}