{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:MAINENTRD2PAR7URDA2B4KJRDO","short_pith_number":"pith:MAINENTR","canonical_record":{"source":{"id":"2410.01072","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-10-01T21:02:16Z","cross_cats_sorted":["cs.CV","q-bio.QM"],"title_canon_sha256":"e74c515e079f96f0f1bf6af8429e9c2df7ece599324f507c72ce587e60fdebcb","abstract_canon_sha256":"97bce1eefa5836613c45b221a8003f532f4b29f6eb89be241f72a84ab8dbd5ae"},"schema_version":"1.0"},"canonical_sha256":"6010d236711e9e08fe9118341e29311b8b386428b1493102358afeff05bdff00","source":{"kind":"arxiv","id":"2410.01072","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2410.01072","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"arxiv_version","alias_value":"2410.01072v1","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2410.01072","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"pith_short_12","alias_value":"MAINENTRD2PA","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"pith_short_16","alias_value":"MAINENTRD2PAR7UR","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"pith_short_8","alias_value":"MAINENTR","created_at":"2026-07-05T09:14:42Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:MAINENTRD2PAR7URDA2B4KJRDO","target":"record","payload":{"canonical_record":{"source":{"id":"2410.01072","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-10-01T21:02:16Z","cross_cats_sorted":["cs.CV","q-bio.QM"],"title_canon_sha256":"e74c515e079f96f0f1bf6af8429e9c2df7ece599324f507c72ce587e60fdebcb","abstract_canon_sha256":"97bce1eefa5836613c45b221a8003f532f4b29f6eb89be241f72a84ab8dbd5ae"},"schema_version":"1.0"},"canonical_sha256":"6010d236711e9e08fe9118341e29311b8b386428b1493102358afeff05bdff00","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:14:42.978056Z","signature_b64":"oM5iJOlsFfHe6Zl/G/Hx5WU9HJ0k3qFGbl6TF5kPLz63EaNfPzabR2T8xv/8N4XHtKHJgUEZ2i91ZFjVkDvCCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6010d236711e9e08fe9118341e29311b8b386428b1493102358afeff05bdff00","last_reissued_at":"2026-07-05T09:14:42.977584Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:14:42.977584Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2410.01072","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:14:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"YKvoyvvMQwmyjW0H7xRgd/FtYUJmPjf9sP+CLIC6+Mlg7kZr/cvWks0232GRDKscDlIUzTj0WR4NKJ3b0LucDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T10:07:12.541706Z"},"content_sha256":"37f4d83e3094dfc0dff48c04d618b2c36e0b8644c962bb9d7f045e12bffc9752","schema_version":"1.0","event_id":"sha256:37f4d83e3094dfc0dff48c04d618b2c36e0b8644c962bb9d7f045e12bffc9752"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:MAINENTRD2PAR7URDA2B4KJRDO","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Generating Seamless Virtual Immunohistochemical Whole Slide Images with Content and Color Consistency","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.CV","q-bio.QM"],"primary_cat":"eess.IV","authors_text":"David E Elder, Joann G Elmore, Kechun Liu, Linda Shapiro, Megan M. Eguchi, Samuel Margolis, Sitong Liu, Stevan R. Knezevich, Wenjun Wu","submitted_at":"2024-10-01T21:02:16Z","abstract_excerpt":"Immunohistochemical (IHC) stains play a vital role in a pathologist's analysis of medical images, providing crucial diagnostic information for various diseases. Virtual staining from hematoxylin and eosin (H&E)-stained whole slide images (WSIs) allows the automatic production of other useful IHC stains without the expensive physical staining process. However, current virtual WSI generation methods based on tile-wise processing often suffer from inconsistencies in content, texture, and color at tile boundaries. These inconsistencies lead to artifacts that compromise image quality and potentiall"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2410.01072","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2410.01072/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:14:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5RnC6GQx46KG+uRuQY1PS/hOetik68JORz4254zuc4Rx/nQf3w1KMNBWydAk9f+9G13jx1+GBYgy91ZreH3wAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T10:07:12.542219Z"},"content_sha256":"fc3c85aa8c295975ed27258ff4b27eee9deb84b3e6c7fcf70786ad8d9d99d514","schema_version":"1.0","event_id":"sha256:fc3c85aa8c295975ed27258ff4b27eee9deb84b3e6c7fcf70786ad8d9d99d514"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/MAINENTRD2PAR7URDA2B4KJRDO/bundle.json","state_url":"https://pith.science/pith/MAINENTRD2PAR7URDA2B4KJRDO/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/MAINENTRD2PAR7URDA2B4KJRDO/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-19T10:07:12Z","links":{"resolver":"https://pith.science/pith/MAINENTRD2PAR7URDA2B4KJRDO","bundle":"https://pith.science/pith/MAINENTRD2PAR7URDA2B4KJRDO/bundle.json","state":"https://pith.science/pith/MAINENTRD2PAR7URDA2B4KJRDO/state.json","well_known_bundle":"https://pith.science/.well-known/pith/MAINENTRD2PAR7URDA2B4KJRDO/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:MAINENTRD2PAR7URDA2B4KJRDO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"97bce1eefa5836613c45b221a8003f532f4b29f6eb89be241f72a84ab8dbd5ae","cross_cats_sorted":["cs.CV","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-10-01T21:02:16Z","title_canon_sha256":"e74c515e079f96f0f1bf6af8429e9c2df7ece599324f507c72ce587e60fdebcb"},"schema_version":"1.0","source":{"id":"2410.01072","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2410.01072","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"arxiv_version","alias_value":"2410.01072v1","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2410.01072","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"pith_short_12","alias_value":"MAINENTRD2PA","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"pith_short_16","alias_value":"MAINENTRD2PAR7UR","created_at":"2026-07-05T09:14:42Z"},{"alias_kind":"pith_short_8","alias_value":"MAINENTR","created_at":"2026-07-05T09:14:42Z"}],"graph_snapshots":[{"event_id":"sha256:fc3c85aa8c295975ed27258ff4b27eee9deb84b3e6c7fcf70786ad8d9d99d514","target":"graph","created_at":"2026-07-05T09:14:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2410.01072/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Immunohistochemical (IHC) stains play a vital role in a pathologist's analysis of medical images, providing crucial diagnostic information for various diseases. Virtual staining from hematoxylin and eosin (H&E)-stained whole slide images (WSIs) allows the automatic production of other useful IHC stains without the expensive physical staining process. However, current virtual WSI generation methods based on tile-wise processing often suffer from inconsistencies in content, texture, and color at tile boundaries. These inconsistencies lead to artifacts that compromise image quality and potentiall","authors_text":"David E Elder, Joann G Elmore, Kechun Liu, Linda Shapiro, Megan M. Eguchi, Samuel Margolis, Sitong Liu, Stevan R. Knezevich, Wenjun Wu","cross_cats":["cs.CV","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-10-01T21:02:16Z","title":"Generating Seamless Virtual Immunohistochemical Whole Slide Images with Content and Color Consistency"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2410.01072","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:37f4d83e3094dfc0dff48c04d618b2c36e0b8644c962bb9d7f045e12bffc9752","target":"record","created_at":"2026-07-05T09:14:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"97bce1eefa5836613c45b221a8003f532f4b29f6eb89be241f72a84ab8dbd5ae","cross_cats_sorted":["cs.CV","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-10-01T21:02:16Z","title_canon_sha256":"e74c515e079f96f0f1bf6af8429e9c2df7ece599324f507c72ce587e60fdebcb"},"schema_version":"1.0","source":{"id":"2410.01072","kind":"arxiv","version":1}},"canonical_sha256":"6010d236711e9e08fe9118341e29311b8b386428b1493102358afeff05bdff00","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6010d236711e9e08fe9118341e29311b8b386428b1493102358afeff05bdff00","first_computed_at":"2026-07-05T09:14:42.977584Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:14:42.977584Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"oM5iJOlsFfHe6Zl/G/Hx5WU9HJ0k3qFGbl6TF5kPLz63EaNfPzabR2T8xv/8N4XHtKHJgUEZ2i91ZFjVkDvCCQ==","signature_status":"signed_v1","signed_at":"2026-07-05T09:14:42.978056Z","signed_message":"canonical_sha256_bytes"},"source_id":"2410.01072","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:37f4d83e3094dfc0dff48c04d618b2c36e0b8644c962bb9d7f045e12bffc9752","sha256:fc3c85aa8c295975ed27258ff4b27eee9deb84b3e6c7fcf70786ad8d9d99d514"],"state_sha256":"7d3bd5888708b6c946e3663b40b9487987adb20a6e40e25840a4e1d03d93f8a1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OXRJJx34QqjGw9XQVTka4XVF9+Qj3mJXhWJXMW7382AKSt0BZw9uP5Rgd9Db67nexTPSyuFoxRSIHLEJlCb2DA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-19T10:07:12.545800Z","bundle_sha256":"bab460985962f59ad83fcbfbd2fd98073375ca7dfc6c575b5c9cf1974a919e36"}}