{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2011:MBPYTWNUABYERFTWFRCLZRVKWW","short_pith_number":"pith:MBPYTWNU","schema_version":"1.0","canonical_sha256":"605f89d9b400704896762c44bcc6aab5b1c938a149412a0b6fbe8769d9a68433","source":{"kind":"arxiv","id":"1103.2834","version":1},"attestation_state":"computed","paper":{"title":"Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.SC","authors_text":"Anirvan M. Sengupta, Paul D. Schedl, Swagatam Mukhopadhyay, Vasily M. Studitsky","submitted_at":"2011-03-15T03:09:12Z","abstract_excerpt":"Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long distance regulatory interactions. The mechanistic basis for insulator activity and how it relates to enhancer action-at-a-distance remains unclear. Here we explore the idea that topological loops could simultaneously account for regulatory interactions of distal enhancers and the insulating activity of boundary elements. We show that while loop formation is not in itself sufficient to explain action at a distance, "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1103.2834","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2011-03-15T03:09:12Z","cross_cats_sorted":[],"title_canon_sha256":"bd62bc2c9657d5affc144a83e4859944ec46e76e6a2f9d97563e636f7cfd58c6","abstract_canon_sha256":"9b81a28636287440221c073372949ca574776bdaa149499c71c744787e1b23f7"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:02:53.480204Z","signature_b64":"hUDt2BTIEOWlC67XsWy9BZTD9uLg5tmaMddW+S4tGfzn2U3dODSOhriErj88eDrhV/OmdlDG4r2kpplD0kXHCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"605f89d9b400704896762c44bcc6aab5b1c938a149412a0b6fbe8769d9a68433","last_reissued_at":"2026-05-18T02:02:53.479564Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:02:53.479564Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.SC","authors_text":"Anirvan M. Sengupta, Paul D. Schedl, Swagatam Mukhopadhyay, Vasily M. Studitsky","submitted_at":"2011-03-15T03:09:12Z","abstract_excerpt":"Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long distance regulatory interactions. The mechanistic basis for insulator activity and how it relates to enhancer action-at-a-distance remains unclear. Here we explore the idea that topological loops could simultaneously account for regulatory interactions of distal enhancers and the insulating activity of boundary elements. We show that while loop formation is not in itself sufficient to explain action at a distance, "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1103.2834","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1103.2834","created_at":"2026-05-18T02:02:53.479658+00:00"},{"alias_kind":"arxiv_version","alias_value":"1103.2834v1","created_at":"2026-05-18T02:02:53.479658+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1103.2834","created_at":"2026-05-18T02:02:53.479658+00:00"},{"alias_kind":"pith_short_12","alias_value":"MBPYTWNUABYE","created_at":"2026-05-18T12:26:34.985390+00:00"},{"alias_kind":"pith_short_16","alias_value":"MBPYTWNUABYERFTW","created_at":"2026-05-18T12:26:34.985390+00:00"},{"alias_kind":"pith_short_8","alias_value":"MBPYTWNU","created_at":"2026-05-18T12:26:34.985390+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW","json":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW.json","graph_json":"https://pith.science/api/pith-number/MBPYTWNUABYERFTWFRCLZRVKWW/graph.json","events_json":"https://pith.science/api/pith-number/MBPYTWNUABYERFTWFRCLZRVKWW/events.json","paper":"https://pith.science/paper/MBPYTWNU"},"agent_actions":{"view_html":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW","download_json":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW.json","view_paper":"https://pith.science/paper/MBPYTWNU","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1103.2834&json=true","fetch_graph":"https://pith.science/api/pith-number/MBPYTWNUABYERFTWFRCLZRVKWW/graph.json","fetch_events":"https://pith.science/api/pith-number/MBPYTWNUABYERFTWFRCLZRVKWW/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW/action/timestamp_anchor","attest_storage":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW/action/storage_attestation","attest_author":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW/action/author_attestation","sign_citation":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW/action/citation_signature","submit_replication":"https://pith.science/pith/MBPYTWNUABYERFTWFRCLZRVKWW/action/replication_record"}},"created_at":"2026-05-18T02:02:53.479658+00:00","updated_at":"2026-05-18T02:02:53.479658+00:00"}