{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:MHOTHFL3ISRIPV54Z7AO4LP36A","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"49ecaa5d27acef20d0b417c4fb646a21ca5e2ac2ab4642e91e77c137ea3d778e","cross_cats_sorted":["cs.AI","cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.CV","submitted_at":"2026-02-02T14:07:33Z","title_canon_sha256":"7c3bfd4c00e700dd6ee2c2a2b9bea2772d1febe08309ba0f901cf098c3dffa57"},"schema_version":"1.0","source":{"id":"2602.02124","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2602.02124","created_at":"2026-07-01T01:17:13Z"},{"alias_kind":"arxiv_version","alias_value":"2602.02124v2","created_at":"2026-07-01T01:17:13Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2602.02124","created_at":"2026-07-01T01:17:13Z"},{"alias_kind":"pith_short_12","alias_value":"MHOTHFL3ISRI","created_at":"2026-07-01T01:17:13Z"},{"alias_kind":"pith_short_16","alias_value":"MHOTHFL3ISRIPV54","created_at":"2026-07-01T01:17:13Z"},{"alias_kind":"pith_short_8","alias_value":"MHOTHFL3","created_at":"2026-07-01T01:17:13Z"}],"graph_snapshots":[{"event_id":"sha256:3f9a555e07ad8a96cfa2b78424a127af5001edd4a197caf83ac2162c37ef145c","target":"graph","created_at":"2026-07-01T01:17:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2602.02124/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Drug-induced toxicity is a leading cause of preclinical and early-clinical failure, making early detection critical. Histopathology is the gold standard for toxicity assessment but relies on expert pathologists, creating a bottleneck for large-scale screening. We introduce an AI-based anomaly detection framework for whole-slide images (WSIs) of rodent liver that identifies healthy tissue and known pathologies (anomalies) and flags samples without training data as out-of-distribution (OOD). We evaluate OOD detection on two held-out categories: apoptosis (single-cell, near-OOD) and staining/proc","authors_text":"Charlotte Lempp, Dhrupal Patel, Fabian Heinemann, Matthias Hein, Olga Graf, Peter Gro{\\ss}","cross_cats":["cs.AI","cs.LG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.CV","submitted_at":"2026-02-02T14:07:33Z","title":"Toxicity Assessment in Preclinical Histopathology via Class-Aware Mahalanobis Distance for Known and Novel Anomalies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2602.02124","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:577edf1e470d2d470a0146a76097d732b26b4944062610f4992e4a07b5463dc1","target":"record","created_at":"2026-07-01T01:17:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"49ecaa5d27acef20d0b417c4fb646a21ca5e2ac2ab4642e91e77c137ea3d778e","cross_cats_sorted":["cs.AI","cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.CV","submitted_at":"2026-02-02T14:07:33Z","title_canon_sha256":"7c3bfd4c00e700dd6ee2c2a2b9bea2772d1febe08309ba0f901cf098c3dffa57"},"schema_version":"1.0","source":{"id":"2602.02124","kind":"arxiv","version":2}},"canonical_sha256":"61dd33957b44a287d7bccfc0ee2dfbf03bd6ea5ae8bfac507d0d11b66fd916d8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"61dd33957b44a287d7bccfc0ee2dfbf03bd6ea5ae8bfac507d0d11b66fd916d8","first_computed_at":"2026-07-01T01:17:13.228071Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-01T01:17:13.228071Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"jKdHzLIIiZ4uU8FWIz3EHxTtcBrPNde03lh3mI9P1L/NShJAZ0LdqvQD9KIi/eGnMwGdOgGy6V2TNzIIqs4mDA==","signature_status":"signed_v1","signed_at":"2026-07-01T01:17:13.228597Z","signed_message":"canonical_sha256_bytes"},"source_id":"2602.02124","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:577edf1e470d2d470a0146a76097d732b26b4944062610f4992e4a07b5463dc1","sha256:3f9a555e07ad8a96cfa2b78424a127af5001edd4a197caf83ac2162c37ef145c"],"state_sha256":"d891441ae6087510fd592f2857a5da96703c7c84d3ac6a3465ab66e21390ead9"}