{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:MM2NUDEU74THZCIZCG4AHNFORN","merge_version":"pith-open-graph-merge-v1","event_count":5,"valid_event_count":5,"invalid_event_count":0,"equivocation_count":1,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"603142c1e9093f6430e852b619fcbd877d3a3773950a33de547807df1aedcb38","cross_cats_sorted":["cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2026-05-12T22:16:00Z","title_canon_sha256":"8569c116100dcf90790c5169f7425d307709d127d70eba6cfcef7db84acda133"},"schema_version":"1.0","source":{"id":"2605.18831","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2605.18831","created_at":"2026-05-20T00:06:24Z"},{"alias_kind":"arxiv_version","alias_value":"2605.18831v1","created_at":"2026-05-20T00:06:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2605.18831","created_at":"2026-05-20T00:06:24Z"},{"alias_kind":"pith_short_12","alias_value":"MM2NUDEU74TH","created_at":"2026-05-20T00:06:24Z"},{"alias_kind":"pith_short_16","alias_value":"MM2NUDEU74THZCIZ","created_at":"2026-05-20T00:06:24Z"},{"alias_kind":"pith_short_8","alias_value":"MM2NUDEU","created_at":"2026-05-20T00:06:24Z"}],"graph_snapshots":[{"event_id":"sha256:3fff85e834f03ef797ed21f3304844ca865a5277fb8eea35805e071b235d25cd","target":"graph","created_at":"2026-05-20T00:06:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2605.18831/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Cold-chain storage limits access to insulin for hundreds of millions of people; a thermally protective patch polymer could help, but the design space is too large for exhaustive experiment. Starting from that problem, we narrow to an agentic workflow: a large language model (LLM) calls physics-based tools through the Model Context Protocol (MCP), searching the discrete PSMILES space under a budget of OpenMM Packmol-matrix evaluations. The LLM acts as an implicit acquisition function conditioned on a persistent \"discovery world\": hypotheses, literature claims, and simulation outcomes updated ea","authors_text":"Martins Otun","cross_cats":["cs.LG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2026-05-12T22:16:00Z","title":"Towards Discovery of Polymers for Insulin Delivery via Physics-Grounded Agentic Workflows"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2605.18831","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0bf8c21d58b945b5fc90d4f63e7b0a82b37d44be51356dd44d5d8bb409a04dbc","target":"record","created_at":"2026-05-20T00:06:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"603142c1e9093f6430e852b619fcbd877d3a3773950a33de547807df1aedcb38","cross_cats_sorted":["cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2026-05-12T22:16:00Z","title_canon_sha256":"8569c116100dcf90790c5169f7425d307709d127d70eba6cfcef7db84acda133"},"schema_version":"1.0","source":{"id":"2605.18831","kind":"arxiv","version":1}},"canonical_sha256":"6334da0c94ff267c891911b803b4ae8b7af8ec69143aad878e700511d51a0bd3","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6334da0c94ff267c891911b803b4ae8b7af8ec69143aad878e700511d51a0bd3","first_computed_at":"2026-05-20T00:06:24.848065Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-20T00:06:24.848065Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"oBEhl1nGu5negNztFOPFPERc4K9V2GX/79Rn1sBwN2gBkScyBh/eMQ9v1uXxNMOKpWZrG8TuDte6MFzT408eBA==","signature_status":"signed_v1","signed_at":"2026-05-20T00:06:24.848769Z","signed_message":"canonical_sha256_bytes"},"source_id":"2605.18831","source_kind":"arxiv","source_version":1}}},"equivocations":[{"signer_id":"pith.science","event_type":"integrity_finding","target":"integrity","event_ids":["sha256:46c0ffd9ee7fb80a73b5b7e1cf48f8bd08f32f1c648471d07f748c50c2cc1fc8","sha256:874b8b251b2dfd072cf6417bab4636f5e24ce9d703685f8f3836da04da8b5d33","sha256:a706468a9d03f0659795ead282a0284338609906e6964bdd7c88172244d5309e"]}],"invalid_events":[],"applied_event_ids":["sha256:0bf8c21d58b945b5fc90d4f63e7b0a82b37d44be51356dd44d5d8bb409a04dbc","sha256:3fff85e834f03ef797ed21f3304844ca865a5277fb8eea35805e071b235d25cd"],"state_sha256":"8c6e1c7220d00cbde990f3b0432f68a9bfc171535d254083ecb11c1703df418e"}