{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:MOCPZ3WSE3DJFO2ZNM27U6IAPA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"908a2cc59247be60e72a316d86f2bd961b1508758a7fcd5721e7656c6adf3c84","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-02-13T02:46:29Z","title_canon_sha256":"36e6fa7259be79934db11510a34530a77c81f6962c33212acbee8a955434c257"},"schema_version":"1.0","source":{"id":"2602.20176","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2602.20176","created_at":"2026-05-29T01:05:05Z"},{"alias_kind":"arxiv_version","alias_value":"2602.20176v2","created_at":"2026-05-29T01:05:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2602.20176","created_at":"2026-05-29T01:05:05Z"},{"alias_kind":"pith_short_12","alias_value":"MOCPZ3WSE3DJ","created_at":"2026-05-29T01:05:05Z"},{"alias_kind":"pith_short_16","alias_value":"MOCPZ3WSE3DJFO2Z","created_at":"2026-05-29T01:05:05Z"},{"alias_kind":"pith_short_8","alias_value":"MOCPZ3WS","created_at":"2026-05-29T01:05:05Z"}],"graph_snapshots":[{"event_id":"sha256:b16680cba7e65126613febc041715319dd19d1a35aef3ae07b54fdeb0f4bcd2c","target":"graph","created_at":"2026-05-29T01:05:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2602.20176/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"D-peptide binders targeting L-proteins have promising therapeutic potential. Despite rapid advances in machine learning-based target-conditioned peptide design, generating D-peptide binders remains largely unexplored. In this work, we show that by injecting axial features to $E(3)$-equivariant (polar) vector features, it is feasible to achieve cross-chirality generalization from homo-chiral (L--L) training data to hetero-chiral (D--L) design tasks. By implementing this method within a latent diffusion model, we achieved D-peptide binder design that not only outperforms existing tools in \\texti","authors_text":"Hao Wang, Jiqing Zheng, Juncai He, Lei Liu, Tianyi Zhang, Yanyan Lan, Yinjun Jia, Yubu Su, Zitong Tian, Ziyi Yang","cross_cats":["cs.LG"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-02-13T02:46:29Z","title":"Cross-Chirality Generalization by Axial Vectors for Hetero-Chiral Protein-Peptide Interaction Design"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2602.20176","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8f4724eb5ba773791c1cce9bd7627d334549eebd7a1ea20297078dbd22f7db22","target":"record","created_at":"2026-05-29T01:05:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"908a2cc59247be60e72a316d86f2bd961b1508758a7fcd5721e7656c6adf3c84","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-02-13T02:46:29Z","title_canon_sha256":"36e6fa7259be79934db11510a34530a77c81f6962c33212acbee8a955434c257"},"schema_version":"1.0","source":{"id":"2602.20176","kind":"arxiv","version":2}},"canonical_sha256":"6384fceed226c692bb596b35fa79007836b531a92c4f3b90573ea4361a7a44c1","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6384fceed226c692bb596b35fa79007836b531a92c4f3b90573ea4361a7a44c1","first_computed_at":"2026-05-29T01:05:05.453989Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-29T01:05:05.453989Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"o5Gxoy9565aZDLixl8P2hrg8pymkQpeAydxLgmcDDHOYEisvxLuLUwNbSgvWnlMV2sfV7+FWjsXfd2Gvw4qBDA==","signature_status":"signed_v1","signed_at":"2026-05-29T01:05:05.454726Z","signed_message":"canonical_sha256_bytes"},"source_id":"2602.20176","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8f4724eb5ba773791c1cce9bd7627d334549eebd7a1ea20297078dbd22f7db22","sha256:b16680cba7e65126613febc041715319dd19d1a35aef3ae07b54fdeb0f4bcd2c"],"state_sha256":"a8fb64537e565f4a6eb1f2b4a8122135c2d89c51d3b8ad2dbc7b3ac08fbe5a53"}