{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:MPHTDABB5JL7CUOLOVHSTBFMGX","short_pith_number":"pith:MPHTDABB","canonical_record":{"source":{"id":"2406.07061","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-06-11T08:42:07Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"62924015f6661e571049f8d4e02b9074418d45fc0bb365308de66129f5061335","abstract_canon_sha256":"5c2ed06069f4484b221bfd13a24b40468719aedaa350ec9af37bb03426ef2545"},"schema_version":"1.0"},"canonical_sha256":"63cf318021ea57f151cb754f2984ac35c692033de06c4a545dae59e591524316","source":{"kind":"arxiv","id":"2406.07061","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2406.07061","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"arxiv_version","alias_value":"2406.07061v1","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2406.07061","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"pith_short_12","alias_value":"MPHTDABB5JL7","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"pith_short_16","alias_value":"MPHTDABB5JL7CUOL","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"pith_short_8","alias_value":"MPHTDABB","created_at":"2026-07-05T08:30:17Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:MPHTDABB5JL7CUOLOVHSTBFMGX","target":"record","payload":{"canonical_record":{"source":{"id":"2406.07061","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-06-11T08:42:07Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"62924015f6661e571049f8d4e02b9074418d45fc0bb365308de66129f5061335","abstract_canon_sha256":"5c2ed06069f4484b221bfd13a24b40468719aedaa350ec9af37bb03426ef2545"},"schema_version":"1.0"},"canonical_sha256":"63cf318021ea57f151cb754f2984ac35c692033de06c4a545dae59e591524316","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T08:30:17.717628Z","signature_b64":"0XYGx3buFvUavYIBeKG1y0Jpj0MxscPWBqmWlMCmp6AKz9uYCoT6eV6NMrApXmzLtIPBzu7wfwAz72qynbI2Aw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"63cf318021ea57f151cb754f2984ac35c692033de06c4a545dae59e591524316","last_reissued_at":"2026-07-05T08:30:17.717164Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T08:30:17.717164Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2406.07061","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:30:17Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"b7kZ8J4EkCbsVwH4wK76HO2LiU/aLVptL7vmjFoGlhZd7nDE0B5mwO6N3Sj7WgZs4xUjh45urnfa7PZEaPaTDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-08T21:09:55.009823Z"},"content_sha256":"667916c50a79ad433d40d5cfda467d100a15c6ae96d97cf48899d4c16f1f8862","schema_version":"1.0","event_id":"sha256:667916c50a79ad433d40d5cfda467d100a15c6ae96d97cf48899d4c16f1f8862"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:MPHTDABB5JL7CUOLOVHSTBFMGX","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Triage of 3D pathology data via 2.5D multiple-instance learning to guide pathologist assessments","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.CV"],"primary_cat":"eess.IV","authors_text":"Andrew H. Song, David Brenes, Faisal Mahmood, Fiona Wang, Gan Gao, Jonathan T.C. Liu, Kevin W. Bishop, Lawrence D. True, Rui Wang, Sarah S.L. Chow","submitted_at":"2024-06-11T08:42:07Z","abstract_excerpt":"Accurate patient diagnoses based on human tissue biopsies are hindered by current clinical practice, where pathologists assess only a limited number of thin 2D tissue slices sectioned from 3D volumetric tissue. Recent advances in non-destructive 3D pathology, such as open-top light-sheet microscopy, enable comprehensive imaging of spatially heterogeneous tissue morphologies, offering the feasibility to improve diagnostic determinations. A potential early route towards clinical adoption for 3D pathology is to rely on pathologists for final diagnosis based on viewing familiar 2D H&E-like image s"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2406.07061","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2406.07061/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:30:17Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"UInEcZse5ap5syPbEXMBUkAdSWfxivf/5+XEYaM2SaZZAdiT3SGp27LNaPS9LYX8RYbupT8E4bhTubOOa0yQCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-08T21:09:55.010200Z"},"content_sha256":"c0bb4ec1f587499627b1d5055748c3ec6f786443a599f58594c4e4fd90f0d725","schema_version":"1.0","event_id":"sha256:c0bb4ec1f587499627b1d5055748c3ec6f786443a599f58594c4e4fd90f0d725"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/MPHTDABB5JL7CUOLOVHSTBFMGX/bundle.json","state_url":"https://pith.science/pith/MPHTDABB5JL7CUOLOVHSTBFMGX/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/MPHTDABB5JL7CUOLOVHSTBFMGX/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-08T21:09:55Z","links":{"resolver":"https://pith.science/pith/MPHTDABB5JL7CUOLOVHSTBFMGX","bundle":"https://pith.science/pith/MPHTDABB5JL7CUOLOVHSTBFMGX/bundle.json","state":"https://pith.science/pith/MPHTDABB5JL7CUOLOVHSTBFMGX/state.json","well_known_bundle":"https://pith.science/.well-known/pith/MPHTDABB5JL7CUOLOVHSTBFMGX/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:MPHTDABB5JL7CUOLOVHSTBFMGX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5c2ed06069f4484b221bfd13a24b40468719aedaa350ec9af37bb03426ef2545","cross_cats_sorted":["cs.CV"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-06-11T08:42:07Z","title_canon_sha256":"62924015f6661e571049f8d4e02b9074418d45fc0bb365308de66129f5061335"},"schema_version":"1.0","source":{"id":"2406.07061","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2406.07061","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"arxiv_version","alias_value":"2406.07061v1","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2406.07061","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"pith_short_12","alias_value":"MPHTDABB5JL7","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"pith_short_16","alias_value":"MPHTDABB5JL7CUOL","created_at":"2026-07-05T08:30:17Z"},{"alias_kind":"pith_short_8","alias_value":"MPHTDABB","created_at":"2026-07-05T08:30:17Z"}],"graph_snapshots":[{"event_id":"sha256:c0bb4ec1f587499627b1d5055748c3ec6f786443a599f58594c4e4fd90f0d725","target":"graph","created_at":"2026-07-05T08:30:17Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2406.07061/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Accurate patient diagnoses based on human tissue biopsies are hindered by current clinical practice, where pathologists assess only a limited number of thin 2D tissue slices sectioned from 3D volumetric tissue. Recent advances in non-destructive 3D pathology, such as open-top light-sheet microscopy, enable comprehensive imaging of spatially heterogeneous tissue morphologies, offering the feasibility to improve diagnostic determinations. A potential early route towards clinical adoption for 3D pathology is to rely on pathologists for final diagnosis based on viewing familiar 2D H&E-like image s","authors_text":"Andrew H. Song, David Brenes, Faisal Mahmood, Fiona Wang, Gan Gao, Jonathan T.C. Liu, Kevin W. Bishop, Lawrence D. True, Rui Wang, Sarah S.L. Chow","cross_cats":["cs.CV"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-06-11T08:42:07Z","title":"Triage of 3D pathology data via 2.5D multiple-instance learning to guide pathologist assessments"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2406.07061","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:667916c50a79ad433d40d5cfda467d100a15c6ae96d97cf48899d4c16f1f8862","target":"record","created_at":"2026-07-05T08:30:17Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5c2ed06069f4484b221bfd13a24b40468719aedaa350ec9af37bb03426ef2545","cross_cats_sorted":["cs.CV"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2024-06-11T08:42:07Z","title_canon_sha256":"62924015f6661e571049f8d4e02b9074418d45fc0bb365308de66129f5061335"},"schema_version":"1.0","source":{"id":"2406.07061","kind":"arxiv","version":1}},"canonical_sha256":"63cf318021ea57f151cb754f2984ac35c692033de06c4a545dae59e591524316","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"63cf318021ea57f151cb754f2984ac35c692033de06c4a545dae59e591524316","first_computed_at":"2026-07-05T08:30:17.717164Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T08:30:17.717164Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"0XYGx3buFvUavYIBeKG1y0Jpj0MxscPWBqmWlMCmp6AKz9uYCoT6eV6NMrApXmzLtIPBzu7wfwAz72qynbI2Aw==","signature_status":"signed_v1","signed_at":"2026-07-05T08:30:17.717628Z","signed_message":"canonical_sha256_bytes"},"source_id":"2406.07061","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:667916c50a79ad433d40d5cfda467d100a15c6ae96d97cf48899d4c16f1f8862","sha256:c0bb4ec1f587499627b1d5055748c3ec6f786443a599f58594c4e4fd90f0d725"],"state_sha256":"de0ce62ee377c549e5b3ed525c51edd439b7f83855d6e397e1e3c8f1572fad7a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iqdVGuZmlKIMAQAVsko+Z2Uu2ZD8QHY3Er6oLhjhArAx0YYsLE4GmGkMei6Xv81GY5CybvuM7KNNTWOeXW60Ag==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-08T21:09:55.012442Z","bundle_sha256":"42dcc1c312891bb3e987f1366224b4702cc5b811391ca8c243bf1c5e85a59f33"}}