{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2017:MPS2SUMZCRRQIGQHPJMI42VEKK","short_pith_number":"pith:MPS2SUMZ","schema_version":"1.0","canonical_sha256":"63e5a951991463041a077a588e6aa452b32ca525f56d2a7393e11bbaacf57dfd","source":{"kind":"arxiv","id":"1708.00942","version":2},"attestation_state":"computed","paper":{"title":"Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Andrew C. Titman, Fang Wan, Thomas F. Jaki","submitted_at":"2017-08-02T21:48:18Z","abstract_excerpt":"Analysing subgroups defined by biomarkers is of increasing importance in clinical research. In some situations the biomarker is subject to misclassification error, meaning the true subgroups are identified with imperfect sensitivity and specificity. For time-to-event data, it is improper to assume the Cox proportional hazards model for the effects with respect to the true subgroups, since the survival distributions with respect to the diagnosed subgroups will not adhere to the proportional hazards assumption. This precludes the possibility of using simple adjustment procedures. Instead, we pre"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1708.00942","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2017-08-02T21:48:18Z","cross_cats_sorted":[],"title_canon_sha256":"5617b00a52dd023d497b1d1931dc6350b6e367f146ee080b398808b3e44d84e7","abstract_canon_sha256":"36daa431696327129c6081ac881f26de33150beb0af3ca502ac6fc0e7e73e141"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:26:07.812906Z","signature_b64":"ifgSI6k8iQgW6XHmXLxefnVsMgzOZOp9b6W286/EI+kpRd4WL/oFwCVZ9YO4UnfA0aQv3xGMl7CJtlSCjrSUCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"63e5a951991463041a077a588e6aa452b32ca525f56d2a7393e11bbaacf57dfd","last_reissued_at":"2026-05-18T00:26:07.812234Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:26:07.812234Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Andrew C. Titman, Fang Wan, Thomas F. Jaki","submitted_at":"2017-08-02T21:48:18Z","abstract_excerpt":"Analysing subgroups defined by biomarkers is of increasing importance in clinical research. In some situations the biomarker is subject to misclassification error, meaning the true subgroups are identified with imperfect sensitivity and specificity. For time-to-event data, it is improper to assume the Cox proportional hazards model for the effects with respect to the true subgroups, since the survival distributions with respect to the diagnosed subgroups will not adhere to the proportional hazards assumption. This precludes the possibility of using simple adjustment procedures. Instead, we pre"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1708.00942","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1708.00942","created_at":"2026-05-18T00:26:07.812338+00:00"},{"alias_kind":"arxiv_version","alias_value":"1708.00942v2","created_at":"2026-05-18T00:26:07.812338+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1708.00942","created_at":"2026-05-18T00:26:07.812338+00:00"},{"alias_kind":"pith_short_12","alias_value":"MPS2SUMZCRRQ","created_at":"2026-05-18T12:31:31.346846+00:00"},{"alias_kind":"pith_short_16","alias_value":"MPS2SUMZCRRQIGQH","created_at":"2026-05-18T12:31:31.346846+00:00"},{"alias_kind":"pith_short_8","alias_value":"MPS2SUMZ","created_at":"2026-05-18T12:31:31.346846+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK","json":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK.json","graph_json":"https://pith.science/api/pith-number/MPS2SUMZCRRQIGQHPJMI42VEKK/graph.json","events_json":"https://pith.science/api/pith-number/MPS2SUMZCRRQIGQHPJMI42VEKK/events.json","paper":"https://pith.science/paper/MPS2SUMZ"},"agent_actions":{"view_html":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK","download_json":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK.json","view_paper":"https://pith.science/paper/MPS2SUMZ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1708.00942&json=true","fetch_graph":"https://pith.science/api/pith-number/MPS2SUMZCRRQIGQHPJMI42VEKK/graph.json","fetch_events":"https://pith.science/api/pith-number/MPS2SUMZCRRQIGQHPJMI42VEKK/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK/action/timestamp_anchor","attest_storage":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK/action/storage_attestation","attest_author":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK/action/author_attestation","sign_citation":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK/action/citation_signature","submit_replication":"https://pith.science/pith/MPS2SUMZCRRQIGQHPJMI42VEKK/action/replication_record"}},"created_at":"2026-05-18T00:26:07.812338+00:00","updated_at":"2026-05-18T00:26:07.812338+00:00"}