{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:MPXC6VYANQ37WZBDJ3TYZRCCFB","short_pith_number":"pith:MPXC6VYA","canonical_record":{"source":{"id":"1611.05344","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-16T16:22:48Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"bb20d57888c315152c210b373161f888b5df68f07166319b6026d05be3d07901","abstract_canon_sha256":"1bcaeb331d48b040e084189646f8b0d65fd078b06327589f040f552d9ad0d8f4"},"schema_version":"1.0"},"canonical_sha256":"63ee2f57006c37fb64234ee78cc442284e34105ec6e69a0e76976f213846e45f","source":{"kind":"arxiv","id":"1611.05344","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1611.05344","created_at":"2026-05-18T00:11:00Z"},{"alias_kind":"arxiv_version","alias_value":"1611.05344v2","created_at":"2026-05-18T00:11:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1611.05344","created_at":"2026-05-18T00:11:00Z"},{"alias_kind":"pith_short_12","alias_value":"MPXC6VYANQ37","created_at":"2026-05-18T12:30:32Z"},{"alias_kind":"pith_short_16","alias_value":"MPXC6VYANQ37WZBD","created_at":"2026-05-18T12:30:32Z"},{"alias_kind":"pith_short_8","alias_value":"MPXC6VYA","created_at":"2026-05-18T12:30:32Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:MPXC6VYANQ37WZBDJ3TYZRCCFB","target":"record","payload":{"canonical_record":{"source":{"id":"1611.05344","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-16T16:22:48Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"bb20d57888c315152c210b373161f888b5df68f07166319b6026d05be3d07901","abstract_canon_sha256":"1bcaeb331d48b040e084189646f8b0d65fd078b06327589f040f552d9ad0d8f4"},"schema_version":"1.0"},"canonical_sha256":"63ee2f57006c37fb64234ee78cc442284e34105ec6e69a0e76976f213846e45f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:11:00.662198Z","signature_b64":"IlobWdmYqbAATEHZUfkZNtqjukExw3yQzPuNYb0yd4bn81hjf2GsTCd/1P3WEAN40ifJr4HUiXiy3waQMXJEDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"63ee2f57006c37fb64234ee78cc442284e34105ec6e69a0e76976f213846e45f","last_reissued_at":"2026-05-18T00:11:00.661351Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:11:00.661351Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1611.05344","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:11:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"aZYPSe+2OEl2Whs9qPUpT9sS9OfSwEMrdxH1USTK4TS/7XYetHUKqeflH3iOfsg16gOsK6LNofkxtw2gb7eYBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-10T01:26:28.460173Z"},"content_sha256":"136be74a98ae407b62b8b0e67bdc120132185c911caad06e240371436ee8dbcf","schema_version":"1.0","event_id":"sha256:136be74a98ae407b62b8b0e67bdc120132185c911caad06e240371436ee8dbcf"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:MPXC6VYANQ37WZBDJ3TYZRCCFB","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"On composite likelihood in bivariate meta-analysis of diagnostic test accuracy studies","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.AP"],"primary_cat":"stat.ME","authors_text":"Aristidis K. Nikoloulopoulos","submitted_at":"2016-11-16T16:22:48Z","abstract_excerpt":"The composite likelihood (CL) is amongst the computational methods used for estimation of the generalized linear mixed model (GLMM) in the context of bivariate meta-analysis of diagnostic test accuracy studies. Its advantage is that the likelihood can be derived conveniently under the assumption of independence between the random effects, but there has not been a clear analysis of the merit or necessity of this method. For synthesis of diagnostic test accuracy studies, a copula mixed model has been proposed in the biostatistics literature. This general model includes the GLMM as a special case"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1611.05344","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:11:00Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"I12dj6ysuPDws4wtewXTd15I9FdKgdtV7BDUZC58zH08AF0DbdW0Yv+zfJNjI4k08Lec1PHwR0TYJkhJlHz3Ag==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-10T01:26:28.460867Z"},"content_sha256":"a6bd7baa9cf3eda6db40cebc15b346cf8e268d1417365a3f93a4cb508eba7d30","schema_version":"1.0","event_id":"sha256:a6bd7baa9cf3eda6db40cebc15b346cf8e268d1417365a3f93a4cb508eba7d30"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/MPXC6VYANQ37WZBDJ3TYZRCCFB/bundle.json","state_url":"https://pith.science/pith/MPXC6VYANQ37WZBDJ3TYZRCCFB/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/MPXC6VYANQ37WZBDJ3TYZRCCFB/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-10T01:26:28Z","links":{"resolver":"https://pith.science/pith/MPXC6VYANQ37WZBDJ3TYZRCCFB","bundle":"https://pith.science/pith/MPXC6VYANQ37WZBDJ3TYZRCCFB/bundle.json","state":"https://pith.science/pith/MPXC6VYANQ37WZBDJ3TYZRCCFB/state.json","well_known_bundle":"https://pith.science/.well-known/pith/MPXC6VYANQ37WZBDJ3TYZRCCFB/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:MPXC6VYANQ37WZBDJ3TYZRCCFB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1bcaeb331d48b040e084189646f8b0d65fd078b06327589f040f552d9ad0d8f4","cross_cats_sorted":["stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-16T16:22:48Z","title_canon_sha256":"bb20d57888c315152c210b373161f888b5df68f07166319b6026d05be3d07901"},"schema_version":"1.0","source":{"id":"1611.05344","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1611.05344","created_at":"2026-05-18T00:11:00Z"},{"alias_kind":"arxiv_version","alias_value":"1611.05344v2","created_at":"2026-05-18T00:11:00Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1611.05344","created_at":"2026-05-18T00:11:00Z"},{"alias_kind":"pith_short_12","alias_value":"MPXC6VYANQ37","created_at":"2026-05-18T12:30:32Z"},{"alias_kind":"pith_short_16","alias_value":"MPXC6VYANQ37WZBD","created_at":"2026-05-18T12:30:32Z"},{"alias_kind":"pith_short_8","alias_value":"MPXC6VYA","created_at":"2026-05-18T12:30:32Z"}],"graph_snapshots":[{"event_id":"sha256:a6bd7baa9cf3eda6db40cebc15b346cf8e268d1417365a3f93a4cb508eba7d30","target":"graph","created_at":"2026-05-18T00:11:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The composite likelihood (CL) is amongst the computational methods used for estimation of the generalized linear mixed model (GLMM) in the context of bivariate meta-analysis of diagnostic test accuracy studies. Its advantage is that the likelihood can be derived conveniently under the assumption of independence between the random effects, but there has not been a clear analysis of the merit or necessity of this method. For synthesis of diagnostic test accuracy studies, a copula mixed model has been proposed in the biostatistics literature. This general model includes the GLMM as a special case","authors_text":"Aristidis K. Nikoloulopoulos","cross_cats":["stat.AP"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-16T16:22:48Z","title":"On composite likelihood in bivariate meta-analysis of diagnostic test accuracy studies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1611.05344","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:136be74a98ae407b62b8b0e67bdc120132185c911caad06e240371436ee8dbcf","target":"record","created_at":"2026-05-18T00:11:00Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1bcaeb331d48b040e084189646f8b0d65fd078b06327589f040f552d9ad0d8f4","cross_cats_sorted":["stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-16T16:22:48Z","title_canon_sha256":"bb20d57888c315152c210b373161f888b5df68f07166319b6026d05be3d07901"},"schema_version":"1.0","source":{"id":"1611.05344","kind":"arxiv","version":2}},"canonical_sha256":"63ee2f57006c37fb64234ee78cc442284e34105ec6e69a0e76976f213846e45f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"63ee2f57006c37fb64234ee78cc442284e34105ec6e69a0e76976f213846e45f","first_computed_at":"2026-05-18T00:11:00.661351Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:11:00.661351Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"IlobWdmYqbAATEHZUfkZNtqjukExw3yQzPuNYb0yd4bn81hjf2GsTCd/1P3WEAN40ifJr4HUiXiy3waQMXJEDw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:11:00.662198Z","signed_message":"canonical_sha256_bytes"},"source_id":"1611.05344","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:136be74a98ae407b62b8b0e67bdc120132185c911caad06e240371436ee8dbcf","sha256:a6bd7baa9cf3eda6db40cebc15b346cf8e268d1417365a3f93a4cb508eba7d30"],"state_sha256":"a7f061dda1f606f2f719395d319dbe8c29e929c9670488593b307971a5c65097"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QJwoKMNVOEVy1IRjAr9rpftI2guw/wttLICOGneuBW97A/wz9quOz2ByYJcn1TnSfaqcQgTCYrPZ+QBI59i9Ag==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-10T01:26:28.464661Z","bundle_sha256":"bcf7c091453dea2b1649c72e8c1dca567b2e06856874095b97596e00908d75c2"}}