{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:MQJ6TUFL5SHLCF3ZW6ZI24O6DQ","short_pith_number":"pith:MQJ6TUFL","canonical_record":{"source":{"id":"2508.06644","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-08T18:45:54Z","cross_cats_sorted":["eess.IV"],"title_canon_sha256":"3bda11887b468a0eb0d9ee8f7f0d6d0829221f9377cf120e06a3e34a5441d91a","abstract_canon_sha256":"1db579bbc5cc23ca99882d23462cebe8c815c30ebcb4c395f1854d05c6718994"},"schema_version":"1.0"},"canonical_sha256":"6413e9d0abec8eb11779b7b28d71de1c2bfae2f7dc07af26971bcb30e24c1fd9","source":{"kind":"arxiv","id":"2508.06644","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.06644","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"arxiv_version","alias_value":"2508.06644v1","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.06644","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"pith_short_12","alias_value":"MQJ6TUFL5SHL","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"pith_short_16","alias_value":"MQJ6TUFL5SHLCF3Z","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"pith_short_8","alias_value":"MQJ6TUFL","created_at":"2026-07-05T11:51:04Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:MQJ6TUFL5SHLCF3ZW6ZI24O6DQ","target":"record","payload":{"canonical_record":{"source":{"id":"2508.06644","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-08T18:45:54Z","cross_cats_sorted":["eess.IV"],"title_canon_sha256":"3bda11887b468a0eb0d9ee8f7f0d6d0829221f9377cf120e06a3e34a5441d91a","abstract_canon_sha256":"1db579bbc5cc23ca99882d23462cebe8c815c30ebcb4c395f1854d05c6718994"},"schema_version":"1.0"},"canonical_sha256":"6413e9d0abec8eb11779b7b28d71de1c2bfae2f7dc07af26971bcb30e24c1fd9","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:51:04.236885Z","signature_b64":"XOahWE6Y7fphtI8n4yW9Y/+noWSLNOmBhWOjZWlsF7TIQHrcgJr0lkCNuERjXOGIFHvBckaPEfMrC3cr5nyADA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6413e9d0abec8eb11779b7b28d71de1c2bfae2f7dc07af26971bcb30e24c1fd9","last_reissued_at":"2026-07-05T11:51:04.236423Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:51:04.236423Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2508.06644","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:51:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lI1UkZB7e2fxqOHssncXvC9MZxXobqOYggXUOLXrwpr8CJ/ePN/8PX+pP6qH5tH19GEWwOQLa8wSpfk4XVefAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-03T21:44:01.618973Z"},"content_sha256":"24fc5614547d7de5f4f4574ed0f8ad504fa09fcf1ea2eb3a42fb7553587f58fc","schema_version":"1.0","event_id":"sha256:24fc5614547d7de5f4f4574ed0f8ad504fa09fcf1ea2eb3a42fb7553587f58fc"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:MQJ6TUFL5SHLCF3ZW6ZI24O6DQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Detecting Early Kidney Allograft Fibrosis with Multi-b-value Spectral Diffusion MRI","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["eess.IV"],"primary_cat":"physics.med-ph","authors_text":"Bachir Taouli, Ian Bolger, Isaac Stillman, Jonas Jasse, Jonathan Dyke, Mira M. Liu, Octavia Bane, Samira Farouk, Sara Lewis, Sergio Calle, Steven Salvatore, Surya Seshan, Swathi Pavuluri, Tanner Crews, Thangamani Muthukumar, Thomas Gladytz","submitted_at":"2025-08-08T18:45:54Z","abstract_excerpt":"Kidney allograft fibrosis is a marker of chronic kidney disease (CKD) and predicts functional decline, and eventual allograft failure. This study evaluates if spectral diffusion MRI can help detect early development and mild/moderate fibrosis in kidney allografts. In a prospective two-center study of kidney allografts, interstitial fibrosis and tubular atrophy (IFTA) was scored and eGFR was calculated from serum creatinine. Multi-b-value DWI (bvalues=[0,10,30,50,80,120,200,400,800mm2/s]) was post-processed with spectral diffusion, intravoxel incoherent motion (IVIM), and apparent diffusion coe"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.06644","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2508.06644/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:51:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"eLPxFcTKWLeT+tJT3dkvQjfzxkbp3UJz2076ZXd8gD4jl7iU/+Qwx3oXFEJeOleH3Qz5uu1TRsP56bgNnE2TDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-03T21:44:01.619590Z"},"content_sha256":"770ae7627a0984062228ad9a187f1136abe9f238513bcb88b6b17a2770dbaae1","schema_version":"1.0","event_id":"sha256:770ae7627a0984062228ad9a187f1136abe9f238513bcb88b6b17a2770dbaae1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/MQJ6TUFL5SHLCF3ZW6ZI24O6DQ/bundle.json","state_url":"https://pith.science/pith/MQJ6TUFL5SHLCF3ZW6ZI24O6DQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/MQJ6TUFL5SHLCF3ZW6ZI24O6DQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-03T21:44:01Z","links":{"resolver":"https://pith.science/pith/MQJ6TUFL5SHLCF3ZW6ZI24O6DQ","bundle":"https://pith.science/pith/MQJ6TUFL5SHLCF3ZW6ZI24O6DQ/bundle.json","state":"https://pith.science/pith/MQJ6TUFL5SHLCF3ZW6ZI24O6DQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/MQJ6TUFL5SHLCF3ZW6ZI24O6DQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:MQJ6TUFL5SHLCF3ZW6ZI24O6DQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1db579bbc5cc23ca99882d23462cebe8c815c30ebcb4c395f1854d05c6718994","cross_cats_sorted":["eess.IV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-08T18:45:54Z","title_canon_sha256":"3bda11887b468a0eb0d9ee8f7f0d6d0829221f9377cf120e06a3e34a5441d91a"},"schema_version":"1.0","source":{"id":"2508.06644","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.06644","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"arxiv_version","alias_value":"2508.06644v1","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.06644","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"pith_short_12","alias_value":"MQJ6TUFL5SHL","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"pith_short_16","alias_value":"MQJ6TUFL5SHLCF3Z","created_at":"2026-07-05T11:51:04Z"},{"alias_kind":"pith_short_8","alias_value":"MQJ6TUFL","created_at":"2026-07-05T11:51:04Z"}],"graph_snapshots":[{"event_id":"sha256:770ae7627a0984062228ad9a187f1136abe9f238513bcb88b6b17a2770dbaae1","target":"graph","created_at":"2026-07-05T11:51:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2508.06644/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Kidney allograft fibrosis is a marker of chronic kidney disease (CKD) and predicts functional decline, and eventual allograft failure. This study evaluates if spectral diffusion MRI can help detect early development and mild/moderate fibrosis in kidney allografts. In a prospective two-center study of kidney allografts, interstitial fibrosis and tubular atrophy (IFTA) was scored and eGFR was calculated from serum creatinine. Multi-b-value DWI (bvalues=[0,10,30,50,80,120,200,400,800mm2/s]) was post-processed with spectral diffusion, intravoxel incoherent motion (IVIM), and apparent diffusion coe","authors_text":"Bachir Taouli, Ian Bolger, Isaac Stillman, Jonas Jasse, Jonathan Dyke, Mira M. Liu, Octavia Bane, Samira Farouk, Sara Lewis, Sergio Calle, Steven Salvatore, Surya Seshan, Swathi Pavuluri, Tanner Crews, Thangamani Muthukumar, Thomas Gladytz","cross_cats":["eess.IV"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-08T18:45:54Z","title":"Detecting Early Kidney Allograft Fibrosis with Multi-b-value Spectral Diffusion MRI"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.06644","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:24fc5614547d7de5f4f4574ed0f8ad504fa09fcf1ea2eb3a42fb7553587f58fc","target":"record","created_at":"2026-07-05T11:51:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1db579bbc5cc23ca99882d23462cebe8c815c30ebcb4c395f1854d05c6718994","cross_cats_sorted":["eess.IV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2025-08-08T18:45:54Z","title_canon_sha256":"3bda11887b468a0eb0d9ee8f7f0d6d0829221f9377cf120e06a3e34a5441d91a"},"schema_version":"1.0","source":{"id":"2508.06644","kind":"arxiv","version":1}},"canonical_sha256":"6413e9d0abec8eb11779b7b28d71de1c2bfae2f7dc07af26971bcb30e24c1fd9","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6413e9d0abec8eb11779b7b28d71de1c2bfae2f7dc07af26971bcb30e24c1fd9","first_computed_at":"2026-07-05T11:51:04.236423Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:51:04.236423Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XOahWE6Y7fphtI8n4yW9Y/+noWSLNOmBhWOjZWlsF7TIQHrcgJr0lkCNuERjXOGIFHvBckaPEfMrC3cr5nyADA==","signature_status":"signed_v1","signed_at":"2026-07-05T11:51:04.236885Z","signed_message":"canonical_sha256_bytes"},"source_id":"2508.06644","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:24fc5614547d7de5f4f4574ed0f8ad504fa09fcf1ea2eb3a42fb7553587f58fc","sha256:770ae7627a0984062228ad9a187f1136abe9f238513bcb88b6b17a2770dbaae1"],"state_sha256":"a8d02aacfa8f9960162d52524a6a601e63d50e0451b2b4c85d13e869ed1c64f2"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DWTb4UVlOSYIjdZz9x5peCGPYTq3Sph8PQkUO6AIAZna3DHslXnn5gAxHwLTTHu0AHIdwwAJipaoDMp27Rb8Aw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-03T21:44:01.623816Z","bundle_sha256":"31c87a4b8a5b84c75930ebc38ed5bb3c4529c92d5ebf1064579c23983dcc7be0"}}