{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:MRAO7GX64CNU4FWBLLCAJOWM3E","short_pith_number":"pith:MRAO7GX6","canonical_record":{"source":{"id":"2202.07533","kind":"arxiv","version":4},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.PE","submitted_at":"2022-02-15T16:05:37Z","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"title_canon_sha256":"bce9484584ee797e95c6da7e76bca83716feedca48378eab0bf22a8d2016e130","abstract_canon_sha256":"99c0d1ea92102e8a99cf20ab9d9276c7150a927c2b8d98674cf27cbe61f7f645"},"schema_version":"1.0"},"canonical_sha256":"6440ef9afee09b4e16c15ac404baccd93792a4da0e55b3e5c262a9e9b64b26bb","source":{"kind":"arxiv","id":"2202.07533","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2202.07533","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"arxiv_version","alias_value":"2202.07533v4","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2202.07533","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"pith_short_12","alias_value":"MRAO7GX64CNU","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"pith_short_16","alias_value":"MRAO7GX64CNU4FWB","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"pith_short_8","alias_value":"MRAO7GX6","created_at":"2026-07-05T08:31:38Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:MRAO7GX64CNU4FWBLLCAJOWM3E","target":"record","payload":{"canonical_record":{"source":{"id":"2202.07533","kind":"arxiv","version":4},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.PE","submitted_at":"2022-02-15T16:05:37Z","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"title_canon_sha256":"bce9484584ee797e95c6da7e76bca83716feedca48378eab0bf22a8d2016e130","abstract_canon_sha256":"99c0d1ea92102e8a99cf20ab9d9276c7150a927c2b8d98674cf27cbe61f7f645"},"schema_version":"1.0"},"canonical_sha256":"6440ef9afee09b4e16c15ac404baccd93792a4da0e55b3e5c262a9e9b64b26bb","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T08:31:38.035264Z","signature_b64":"JNQf4POFIK4udjyLERct9IgMmJQB8r52vk64+34LTMnCoi3NyABPQfKbBmrD7InqEVugixDHGEmLG6b1tJoOBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6440ef9afee09b4e16c15ac404baccd93792a4da0e55b3e5c262a9e9b64b26bb","last_reissued_at":"2026-07-05T08:31:38.034789Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T08:31:38.034789Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2202.07533","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:31:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PX3dL56jnMvFFYi+4l0F1r8XK7DiWz3MFavlhUtOhpraVu0G1eNLMQGi84x4c3iTzafzYdo9Fucp0mfs4lMtDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T06:21:04.395391Z"},"content_sha256":"1d4d28287aa4db61b915a4e6df4be1bbae7a288a39941e2e3e3c2e8f1159d8bf","schema_version":"1.0","event_id":"sha256:1d4d28287aa4db61b915a4e6df4be1bbae7a288a39941e2e3e3c2e8f1159d8bf"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:MRAO7GX64CNU4FWBLLCAJOWM3E","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Limits on the Evolutionary Rates of Biological Traits","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"primary_cat":"q-bio.PE","authors_text":"Luis Pedro Garc\\'ia-Pintos","submitted_at":"2022-02-15T16:05:37Z","abstract_excerpt":"This paper focuses on the maximum speed at which biological evolution can occur. I derive inequalities that limit the rate of evolutionary processes driven by natural selection, mutations, or genetic drift. These \\emph{rate limits} link the variability in a population to evolutionary rates. In particular, high variances in the fitness of a population and of a quantitative trait allow for fast changes in the trait's average. In contrast, low variability makes a trait less susceptible to random changes due to genetic drift. The results in this article generalize Fisher's fundamental theorem of n"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2202.07533","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2202.07533/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:31:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Uf37Suzr+mV6iMpXYOEB/DMqF4z/M09vwJwPacTxwyd4GIN/BdekNXZ6qW0P0xfSGoDKrHMFgDgJZpWwsw17CA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T06:21:04.396551Z"},"content_sha256":"1176f348a05d5bfb0d6f510f6b6041e750bbcee64acdf64be427317f707460e2","schema_version":"1.0","event_id":"sha256:1176f348a05d5bfb0d6f510f6b6041e750bbcee64acdf64be427317f707460e2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/MRAO7GX64CNU4FWBLLCAJOWM3E/bundle.json","state_url":"https://pith.science/pith/MRAO7GX64CNU4FWBLLCAJOWM3E/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/MRAO7GX64CNU4FWBLLCAJOWM3E/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-13T06:21:04Z","links":{"resolver":"https://pith.science/pith/MRAO7GX64CNU4FWBLLCAJOWM3E","bundle":"https://pith.science/pith/MRAO7GX64CNU4FWBLLCAJOWM3E/bundle.json","state":"https://pith.science/pith/MRAO7GX64CNU4FWBLLCAJOWM3E/state.json","well_known_bundle":"https://pith.science/.well-known/pith/MRAO7GX64CNU4FWBLLCAJOWM3E/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:MRAO7GX64CNU4FWBLLCAJOWM3E","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"99c0d1ea92102e8a99cf20ab9d9276c7150a927c2b8d98674cf27cbe61f7f645","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.PE","submitted_at":"2022-02-15T16:05:37Z","title_canon_sha256":"bce9484584ee797e95c6da7e76bca83716feedca48378eab0bf22a8d2016e130"},"schema_version":"1.0","source":{"id":"2202.07533","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2202.07533","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"arxiv_version","alias_value":"2202.07533v4","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2202.07533","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"pith_short_12","alias_value":"MRAO7GX64CNU","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"pith_short_16","alias_value":"MRAO7GX64CNU4FWB","created_at":"2026-07-05T08:31:38Z"},{"alias_kind":"pith_short_8","alias_value":"MRAO7GX6","created_at":"2026-07-05T08:31:38Z"}],"graph_snapshots":[{"event_id":"sha256:1176f348a05d5bfb0d6f510f6b6041e750bbcee64acdf64be427317f707460e2","target":"graph","created_at":"2026-07-05T08:31:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2202.07533/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"This paper focuses on the maximum speed at which biological evolution can occur. I derive inequalities that limit the rate of evolutionary processes driven by natural selection, mutations, or genetic drift. These \\emph{rate limits} link the variability in a population to evolutionary rates. In particular, high variances in the fitness of a population and of a quantitative trait allow for fast changes in the trait's average. In contrast, low variability makes a trait less susceptible to random changes due to genetic drift. The results in this article generalize Fisher's fundamental theorem of n","authors_text":"Luis Pedro Garc\\'ia-Pintos","cross_cats":["cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.PE","submitted_at":"2022-02-15T16:05:37Z","title":"Limits on the Evolutionary Rates of Biological Traits"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2202.07533","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1d4d28287aa4db61b915a4e6df4be1bbae7a288a39941e2e3e3c2e8f1159d8bf","target":"record","created_at":"2026-07-05T08:31:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"99c0d1ea92102e8a99cf20ab9d9276c7150a927c2b8d98674cf27cbe61f7f645","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph","q-bio.QM"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.PE","submitted_at":"2022-02-15T16:05:37Z","title_canon_sha256":"bce9484584ee797e95c6da7e76bca83716feedca48378eab0bf22a8d2016e130"},"schema_version":"1.0","source":{"id":"2202.07533","kind":"arxiv","version":4}},"canonical_sha256":"6440ef9afee09b4e16c15ac404baccd93792a4da0e55b3e5c262a9e9b64b26bb","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6440ef9afee09b4e16c15ac404baccd93792a4da0e55b3e5c262a9e9b64b26bb","first_computed_at":"2026-07-05T08:31:38.034789Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T08:31:38.034789Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"JNQf4POFIK4udjyLERct9IgMmJQB8r52vk64+34LTMnCoi3NyABPQfKbBmrD7InqEVugixDHGEmLG6b1tJoOBg==","signature_status":"signed_v1","signed_at":"2026-07-05T08:31:38.035264Z","signed_message":"canonical_sha256_bytes"},"source_id":"2202.07533","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1d4d28287aa4db61b915a4e6df4be1bbae7a288a39941e2e3e3c2e8f1159d8bf","sha256:1176f348a05d5bfb0d6f510f6b6041e750bbcee64acdf64be427317f707460e2"],"state_sha256":"5429ea2b0c8ce7d442cd6ef08b36512cd2914dfc0718e3b160d314da1d127a18"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rIjiIOi7/TCymlAbxTpLOVJnjCXzR+o5HSFePSyUf9Xn5WyZ0+iN6/GncqYx1005kQVEV18LQLqMVpzSvb3KAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-13T06:21:04.430605Z","bundle_sha256":"20af49b463cbb9bd629575d472b80a837acc209e1f7ae0480e52a3d26c64b7ac"}}