{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2014:MRYNPUURX26HLXH225TI234RVJ","short_pith_number":"pith:MRYNPUUR","schema_version":"1.0","canonical_sha256":"6470d7d291bebc75dcfad7668d6f91aa610231b27fed73284918867c7fee4bfe","source":{"kind":"arxiv","id":"1402.1781","version":1},"attestation_state":"computed","paper":{"title":"Discovering functional DNA elements using population genomic information: A proof of concept using human mtDNA","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.PE","authors_text":"Andrew D. Kern, Daniel R. Schrider","submitted_at":"2014-02-07T21:56:43Z","abstract_excerpt":"Identifying the complete set of functional elements within the human genome would be a windfall for multiple areas of biological research including medicine, molecular biology, and evolution. Complete knowledge of function would aid in the prioritization of loci when searching for the genetic bases of disease or adaptive phenotypes. Because mutations that disrupt function are disfavored by natural selection, purifying selection leaves a detectable signature within functional elements; accordingly this signal has been exploited through the use of genomic comparisons of distantly related species"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1402.1781","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2014-02-07T21:56:43Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"635f6180a0b98bcd5bac01298bb0eba74742298672affc75e1d9bced11a3341c","abstract_canon_sha256":"dee92c12ea3a39fb33365c09617eeab35716211819e06a4c3a2e12bf3226f731"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:26:19.058852Z","signature_b64":"lcBWuwvA31j6jFhbnTdA8IXu4t4jQGvomfBxMRndGn4UHiUhNUqi+eKiLmtYgUUx5fbcvyyqlFfRAoOL8REeDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6470d7d291bebc75dcfad7668d6f91aa610231b27fed73284918867c7fee4bfe","last_reissued_at":"2026-05-18T01:26:19.058353Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:26:19.058353Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Discovering functional DNA elements using population genomic information: A proof of concept using human mtDNA","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.PE","authors_text":"Andrew D. Kern, Daniel R. Schrider","submitted_at":"2014-02-07T21:56:43Z","abstract_excerpt":"Identifying the complete set of functional elements within the human genome would be a windfall for multiple areas of biological research including medicine, molecular biology, and evolution. Complete knowledge of function would aid in the prioritization of loci when searching for the genetic bases of disease or adaptive phenotypes. Because mutations that disrupt function are disfavored by natural selection, purifying selection leaves a detectable signature within functional elements; accordingly this signal has been exploited through the use of genomic comparisons of distantly related species"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1402.1781","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1402.1781","created_at":"2026-05-18T01:26:19.058444+00:00"},{"alias_kind":"arxiv_version","alias_value":"1402.1781v1","created_at":"2026-05-18T01:26:19.058444+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1402.1781","created_at":"2026-05-18T01:26:19.058444+00:00"},{"alias_kind":"pith_short_12","alias_value":"MRYNPUURX26H","created_at":"2026-05-18T12:28:38.356838+00:00"},{"alias_kind":"pith_short_16","alias_value":"MRYNPUURX26HLXH2","created_at":"2026-05-18T12:28:38.356838+00:00"},{"alias_kind":"pith_short_8","alias_value":"MRYNPUUR","created_at":"2026-05-18T12:28:38.356838+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ","json":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ.json","graph_json":"https://pith.science/api/pith-number/MRYNPUURX26HLXH225TI234RVJ/graph.json","events_json":"https://pith.science/api/pith-number/MRYNPUURX26HLXH225TI234RVJ/events.json","paper":"https://pith.science/paper/MRYNPUUR"},"agent_actions":{"view_html":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ","download_json":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ.json","view_paper":"https://pith.science/paper/MRYNPUUR","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1402.1781&json=true","fetch_graph":"https://pith.science/api/pith-number/MRYNPUURX26HLXH225TI234RVJ/graph.json","fetch_events":"https://pith.science/api/pith-number/MRYNPUURX26HLXH225TI234RVJ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ/action/storage_attestation","attest_author":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ/action/author_attestation","sign_citation":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ/action/citation_signature","submit_replication":"https://pith.science/pith/MRYNPUURX26HLXH225TI234RVJ/action/replication_record"}},"created_at":"2026-05-18T01:26:19.058444+00:00","updated_at":"2026-05-18T01:26:19.058444+00:00"}