{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:MT6NWULL2YM6DLCBLIZDWGF5CX","short_pith_number":"pith:MT6NWULL","canonical_record":{"source":{"id":"2201.09647","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2022-01-21T07:35:24Z","cross_cats_sorted":["cs.AI","cs.LG","q-bio.MN"],"title_canon_sha256":"310585343a6ecaf11eb79ce4478ee717c6dee9377b7181927c8cd2bd1d1f9a00","abstract_canon_sha256":"959fd013b35ec8e20812a132017a0a4cc366adb7dcb8b865299e55be140aee30"},"schema_version":"1.0"},"canonical_sha256":"64fcdb516bd619e1ac415a323b18bd15d868aec3462b50a522ec708cb158b003","source":{"kind":"arxiv","id":"2201.09647","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2201.09647","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"arxiv_version","alias_value":"2201.09647v2","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2201.09647","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"pith_short_12","alias_value":"MT6NWULL2YM6","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"pith_short_16","alias_value":"MT6NWULL2YM6DLCB","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"pith_short_8","alias_value":"MT6NWULL","created_at":"2026-07-05T03:56:33Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:MT6NWULL2YM6DLCBLIZDWGF5CX","target":"record","payload":{"canonical_record":{"source":{"id":"2201.09647","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2022-01-21T07:35:24Z","cross_cats_sorted":["cs.AI","cs.LG","q-bio.MN"],"title_canon_sha256":"310585343a6ecaf11eb79ce4478ee717c6dee9377b7181927c8cd2bd1d1f9a00","abstract_canon_sha256":"959fd013b35ec8e20812a132017a0a4cc366adb7dcb8b865299e55be140aee30"},"schema_version":"1.0"},"canonical_sha256":"64fcdb516bd619e1ac415a323b18bd15d868aec3462b50a522ec708cb158b003","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:56:33.893513Z","signature_b64":"Ne+unQ+famO8LEn7XQO9rkj8Neh7k4z4HkAoJwNCB2S5wMaLcqLwc+HB1Mm2Fut3CVtaSnlEvGqs9N2KCJ9GAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"64fcdb516bd619e1ac415a323b18bd15d868aec3462b50a522ec708cb158b003","last_reissued_at":"2026-07-05T03:56:33.893024Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:56:33.893024Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2201.09647","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:56:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+DWwQgdLWs/sJLKLKuHtsPlnuANKDtq4WyWdEHpIbGGp78S/DjeunR+hOVNK7/ZrQO49v7sgNqyF8G4djvYKCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-05T10:39:46.565348Z"},"content_sha256":"0b06aeac4fe775c65a8d595606a4ce5e0341b95dd9b832827105a1d3ee0e1393","schema_version":"1.0","event_id":"sha256:0b06aeac4fe775c65a8d595606a4ce5e0341b95dd9b832827105a1d3ee0e1393"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:MT6NWULL2YM6DLCBLIZDWGF5CX","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"AlphaFold Accelerates Artificial Intelligence Powered Drug Discovery: Efficient Discovery of a Novel Cyclin-dependent Kinase 20 (CDK20) Small Molecule Inhibitor","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["cs.AI","cs.LG","q-bio.MN"],"primary_cat":"q-bio.BM","authors_text":"Alan Aspuru-Guzik, Alex Aliper, Alexey Mantsyzov, Alex Zhavoronkov, Anastasia Shneyderman, Bonnie Hei Man Liu, Feng Ren, Frank W. Pun, Ivan V. Ozerov, Ju Wang, Michael Levitt, Mikhail Korzinkin, Min Zheng, Shanshan Kong, Vladimir Aladinskiy, Vladimir Naumov, Wei Zhu, Xiao Ding, Xi Long, Xin Cai, Yingtao Liu, Zhongying Cao","submitted_at":"2022-01-21T07:35:24Z","abstract_excerpt":"The AlphaFold computer program predicted protein structures for the whole human genome, which has been considered as a remarkable breakthrough both in artificial intelligence (AI) application and structural biology. Despite the varying confidence level, these predicted structures still could significantly contribute to structure-based drug design of novel targets, especially the ones with no or limited structural information. In this work, we successfully applied AlphaFold in our end-to-end AI-powered drug discovery engines constituted of a biocomputational platform PandaOmics and a generative"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2201.09647","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2201.09647/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:56:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JiCQFN2gzy0WmAg9LQoW0vNolCvg3qC12PKjOYca7sdH/H93uhyi+ssN0xVxmhrxNZVsYcRTYHx9pxILtlKGBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-05T10:39:46.566302Z"},"content_sha256":"2c512475c94589071a5c6527614f68258c321de4c37f218f898b6b64b929ec47","schema_version":"1.0","event_id":"sha256:2c512475c94589071a5c6527614f68258c321de4c37f218f898b6b64b929ec47"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/MT6NWULL2YM6DLCBLIZDWGF5CX/bundle.json","state_url":"https://pith.science/pith/MT6NWULL2YM6DLCBLIZDWGF5CX/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/MT6NWULL2YM6DLCBLIZDWGF5CX/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-05T10:39:46Z","links":{"resolver":"https://pith.science/pith/MT6NWULL2YM6DLCBLIZDWGF5CX","bundle":"https://pith.science/pith/MT6NWULL2YM6DLCBLIZDWGF5CX/bundle.json","state":"https://pith.science/pith/MT6NWULL2YM6DLCBLIZDWGF5CX/state.json","well_known_bundle":"https://pith.science/.well-known/pith/MT6NWULL2YM6DLCBLIZDWGF5CX/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:MT6NWULL2YM6DLCBLIZDWGF5CX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"959fd013b35ec8e20812a132017a0a4cc366adb7dcb8b865299e55be140aee30","cross_cats_sorted":["cs.AI","cs.LG","q-bio.MN"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2022-01-21T07:35:24Z","title_canon_sha256":"310585343a6ecaf11eb79ce4478ee717c6dee9377b7181927c8cd2bd1d1f9a00"},"schema_version":"1.0","source":{"id":"2201.09647","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2201.09647","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"arxiv_version","alias_value":"2201.09647v2","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2201.09647","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"pith_short_12","alias_value":"MT6NWULL2YM6","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"pith_short_16","alias_value":"MT6NWULL2YM6DLCB","created_at":"2026-07-05T03:56:33Z"},{"alias_kind":"pith_short_8","alias_value":"MT6NWULL","created_at":"2026-07-05T03:56:33Z"}],"graph_snapshots":[{"event_id":"sha256:2c512475c94589071a5c6527614f68258c321de4c37f218f898b6b64b929ec47","target":"graph","created_at":"2026-07-05T03:56:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2201.09647/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The AlphaFold computer program predicted protein structures for the whole human genome, which has been considered as a remarkable breakthrough both in artificial intelligence (AI) application and structural biology. Despite the varying confidence level, these predicted structures still could significantly contribute to structure-based drug design of novel targets, especially the ones with no or limited structural information. In this work, we successfully applied AlphaFold in our end-to-end AI-powered drug discovery engines constituted of a biocomputational platform PandaOmics and a generative","authors_text":"Alan Aspuru-Guzik, Alex Aliper, Alexey Mantsyzov, Alex Zhavoronkov, Anastasia Shneyderman, Bonnie Hei Man Liu, Feng Ren, Frank W. Pun, Ivan V. Ozerov, Ju Wang, Michael Levitt, Mikhail Korzinkin, Min Zheng, Shanshan Kong, Vladimir Aladinskiy, Vladimir Naumov, Wei Zhu, Xiao Ding, Xi Long, Xin Cai, Yingtao Liu, Zhongying Cao","cross_cats":["cs.AI","cs.LG","q-bio.MN"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2022-01-21T07:35:24Z","title":"AlphaFold Accelerates Artificial Intelligence Powered Drug Discovery: Efficient Discovery of a Novel Cyclin-dependent Kinase 20 (CDK20) Small Molecule Inhibitor"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2201.09647","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0b06aeac4fe775c65a8d595606a4ce5e0341b95dd9b832827105a1d3ee0e1393","target":"record","created_at":"2026-07-05T03:56:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"959fd013b35ec8e20812a132017a0a4cc366adb7dcb8b865299e55be140aee30","cross_cats_sorted":["cs.AI","cs.LG","q-bio.MN"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2022-01-21T07:35:24Z","title_canon_sha256":"310585343a6ecaf11eb79ce4478ee717c6dee9377b7181927c8cd2bd1d1f9a00"},"schema_version":"1.0","source":{"id":"2201.09647","kind":"arxiv","version":2}},"canonical_sha256":"64fcdb516bd619e1ac415a323b18bd15d868aec3462b50a522ec708cb158b003","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"64fcdb516bd619e1ac415a323b18bd15d868aec3462b50a522ec708cb158b003","first_computed_at":"2026-07-05T03:56:33.893024Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:56:33.893024Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Ne+unQ+famO8LEn7XQO9rkj8Neh7k4z4HkAoJwNCB2S5wMaLcqLwc+HB1Mm2Fut3CVtaSnlEvGqs9N2KCJ9GAQ==","signature_status":"signed_v1","signed_at":"2026-07-05T03:56:33.893513Z","signed_message":"canonical_sha256_bytes"},"source_id":"2201.09647","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0b06aeac4fe775c65a8d595606a4ce5e0341b95dd9b832827105a1d3ee0e1393","sha256:2c512475c94589071a5c6527614f68258c321de4c37f218f898b6b64b929ec47"],"state_sha256":"72847d5e1d4c0159cd6eadda82fd99125b47a2d3c0858b85aa7c73ca073c4dcb"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"yaNY6kF+WenmsWU6yolZTTMsiiXyZq/qIn8Y3dEQZ/2ss8/9vPD0k1yahkpeN+zmrD/tURux2WZWhhBfqwu3BA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-05T10:39:46.571955Z","bundle_sha256":"6b3eaf27ceced44f2abb1c741792b323ea7b2bf79265c6b9f21edf3add539672"}}