{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:MUYF3IPHTNV4EF4RHD7YBAOLCE","short_pith_number":"pith:MUYF3IPH","canonical_record":{"source":{"id":"2411.17242","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2024-11-26T09:13:28Z","cross_cats_sorted":[],"title_canon_sha256":"2c6ab86ee1ee2f7771fd4c8a8df079e8eb6b1a7afe581324babffae9c57b95a1","abstract_canon_sha256":"2722c54b24d643b32534f27c9ddf9f9c74128cc3a839566009409d8e90d3683c"},"schema_version":"1.0"},"canonical_sha256":"65305da1e79b6bc2179138ff8081cb11074aee85d1ca500e6a974eb63e576610","source":{"kind":"arxiv","id":"2411.17242","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.17242","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"arxiv_version","alias_value":"2411.17242v1","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.17242","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"pith_short_12","alias_value":"MUYF3IPHTNV4","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"pith_short_16","alias_value":"MUYF3IPHTNV4EF4R","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"pith_short_8","alias_value":"MUYF3IPH","created_at":"2026-07-05T09:40:45Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:MUYF3IPHTNV4EF4RHD7YBAOLCE","target":"record","payload":{"canonical_record":{"source":{"id":"2411.17242","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2024-11-26T09:13:28Z","cross_cats_sorted":[],"title_canon_sha256":"2c6ab86ee1ee2f7771fd4c8a8df079e8eb6b1a7afe581324babffae9c57b95a1","abstract_canon_sha256":"2722c54b24d643b32534f27c9ddf9f9c74128cc3a839566009409d8e90d3683c"},"schema_version":"1.0"},"canonical_sha256":"65305da1e79b6bc2179138ff8081cb11074aee85d1ca500e6a974eb63e576610","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:40:45.901997Z","signature_b64":"KEq7l6rDDnG2Sro5oucwe8pXF6YTPTx+8U1gXpOPQKo2T7iP3En9E6Sb0lzKbUElupOIBbe3r2AqCR9SIM9rCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"65305da1e79b6bc2179138ff8081cb11074aee85d1ca500e6a974eb63e576610","last_reissued_at":"2026-07-05T09:40:45.901585Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:40:45.901585Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2411.17242","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:40:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rNfgJEYad+b1eefzN5AzVFI/15TH+otLiqJa3/2p5hVkEzE04WSAnMb6bwc+Ftnj8Ezn/u1KnU5jiiEN65rRDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-12T23:09:23.912031Z"},"content_sha256":"c69c5bc8404b3edc18f4ddc72053f3e4b5b80dbde078817867a9e2507dc97abd","schema_version":"1.0","event_id":"sha256:c69c5bc8404b3edc18f4ddc72053f3e4b5b80dbde078817867a9e2507dc97abd"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:MUYF3IPHTNV4EF4RHD7YBAOLCE","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Critically assessing atavism, an evolution-centered and deterministic hypothesis on cancer","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Bertrand Daignan-Fornier, Thomas Pradeu (ImmunoConcept)","submitted_at":"2024-11-26T09:13:28Z","abstract_excerpt":"Cancer is most commonly viewed as resulting from somatic mutations enhancing proliferation and invasion. Some hypotheses further propose that these new capacities reveal a breakdown of multicellularity allowing cancer cells to escape proliferation and cooperation control mechanisms that were implemented during evolution of multicellularity. Here we critically review one such hypothesis, named ``atavism,'' which puts forward the idea that cancer results from the re-expression of normally repressed genes forming a program, or toolbox, inherited from unicellular or simple multicellular ancestors."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.17242","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2411.17242/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:40:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Rmh7Zuqh36ijhuqSxvrbcSFKrQCgji8XYfczRpjnGPVFYmnK2Pmt/CsatOn2PFgxdYwQbSfj079BcrUC/Q1sDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-12T23:09:23.912589Z"},"content_sha256":"dc839d6ded2627ada510848dc657813eb1db82ad9171bd718b25e1a038973d0d","schema_version":"1.0","event_id":"sha256:dc839d6ded2627ada510848dc657813eb1db82ad9171bd718b25e1a038973d0d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/MUYF3IPHTNV4EF4RHD7YBAOLCE/bundle.json","state_url":"https://pith.science/pith/MUYF3IPHTNV4EF4RHD7YBAOLCE/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/MUYF3IPHTNV4EF4RHD7YBAOLCE/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-12T23:09:23Z","links":{"resolver":"https://pith.science/pith/MUYF3IPHTNV4EF4RHD7YBAOLCE","bundle":"https://pith.science/pith/MUYF3IPHTNV4EF4RHD7YBAOLCE/bundle.json","state":"https://pith.science/pith/MUYF3IPHTNV4EF4RHD7YBAOLCE/state.json","well_known_bundle":"https://pith.science/.well-known/pith/MUYF3IPHTNV4EF4RHD7YBAOLCE/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:MUYF3IPHTNV4EF4RHD7YBAOLCE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2722c54b24d643b32534f27c9ddf9f9c74128cc3a839566009409d8e90d3683c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2024-11-26T09:13:28Z","title_canon_sha256":"2c6ab86ee1ee2f7771fd4c8a8df079e8eb6b1a7afe581324babffae9c57b95a1"},"schema_version":"1.0","source":{"id":"2411.17242","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.17242","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"arxiv_version","alias_value":"2411.17242v1","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.17242","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"pith_short_12","alias_value":"MUYF3IPHTNV4","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"pith_short_16","alias_value":"MUYF3IPHTNV4EF4R","created_at":"2026-07-05T09:40:45Z"},{"alias_kind":"pith_short_8","alias_value":"MUYF3IPH","created_at":"2026-07-05T09:40:45Z"}],"graph_snapshots":[{"event_id":"sha256:dc839d6ded2627ada510848dc657813eb1db82ad9171bd718b25e1a038973d0d","target":"graph","created_at":"2026-07-05T09:40:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2411.17242/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Cancer is most commonly viewed as resulting from somatic mutations enhancing proliferation and invasion. Some hypotheses further propose that these new capacities reveal a breakdown of multicellularity allowing cancer cells to escape proliferation and cooperation control mechanisms that were implemented during evolution of multicellularity. Here we critically review one such hypothesis, named ``atavism,'' which puts forward the idea that cancer results from the re-expression of normally repressed genes forming a program, or toolbox, inherited from unicellular or simple multicellular ancestors.","authors_text":"Bertrand Daignan-Fornier, Thomas Pradeu (ImmunoConcept)","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2024-11-26T09:13:28Z","title":"Critically assessing atavism, an evolution-centered and deterministic hypothesis on cancer"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.17242","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c69c5bc8404b3edc18f4ddc72053f3e4b5b80dbde078817867a9e2507dc97abd","target":"record","created_at":"2026-07-05T09:40:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2722c54b24d643b32534f27c9ddf9f9c74128cc3a839566009409d8e90d3683c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2024-11-26T09:13:28Z","title_canon_sha256":"2c6ab86ee1ee2f7771fd4c8a8df079e8eb6b1a7afe581324babffae9c57b95a1"},"schema_version":"1.0","source":{"id":"2411.17242","kind":"arxiv","version":1}},"canonical_sha256":"65305da1e79b6bc2179138ff8081cb11074aee85d1ca500e6a974eb63e576610","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"65305da1e79b6bc2179138ff8081cb11074aee85d1ca500e6a974eb63e576610","first_computed_at":"2026-07-05T09:40:45.901585Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:40:45.901585Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"KEq7l6rDDnG2Sro5oucwe8pXF6YTPTx+8U1gXpOPQKo2T7iP3En9E6Sb0lzKbUElupOIBbe3r2AqCR9SIM9rCA==","signature_status":"signed_v1","signed_at":"2026-07-05T09:40:45.901997Z","signed_message":"canonical_sha256_bytes"},"source_id":"2411.17242","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c69c5bc8404b3edc18f4ddc72053f3e4b5b80dbde078817867a9e2507dc97abd","sha256:dc839d6ded2627ada510848dc657813eb1db82ad9171bd718b25e1a038973d0d"],"state_sha256":"0aa8f484ed324a887ad390addbedb6d28bb5a8828b94f1ff9ee892d5f6a587ad"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TT60XTV3XQcWZj62046D+YOx+WHviLaiUdBkNxI4mndnxMDhMhBtPOcna+XFtNenmHQg44M2j0+nKMFhqPCrCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-12T23:09:23.917738Z","bundle_sha256":"5bdd33edd9256059d19456e2b93738fb1f02409e6be92d97a652b60289e535a1"}}