{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:MVGKU3TWDUKASGOKNUCO7WSIFZ","short_pith_number":"pith:MVGKU3TW","schema_version":"1.0","canonical_sha256":"654caa6e761d140919ca6d04efda482e6a1174885fb4ba0edadc1d8bcab5dcb4","source":{"kind":"arxiv","id":"1512.03094","version":1},"attestation_state":"computed","paper":{"title":"Theoretical knock-outs on biological networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Giuliano Gadioli La Guardia, Murilo da Silva Baptista, Pedro Jeferson Miranda, Sandro Ely de Souza Pinto","submitted_at":"2015-12-01T04:01:01Z","abstract_excerpt":"In this work we formalize a method to compute the degree of importance of biological agents that participates on the dynamics of a biological phenomenon build upon a complex network. We call this new procedure by theoretical knock-out (KO). To devise this method, we make two approaches: algebraically and algorithmically. In both cases we compute a vector on an asymptotic state, called flux vector. The flux is given by a random walk on a directed graph that represents a biological phenomenon. This vector gives us the information about the relative flux of walkers on a vertex which represents a "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1512.03094","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-12-01T04:01:01Z","cross_cats_sorted":[],"title_canon_sha256":"0c042ca64b4c4a07224b98fe351b59a60bae4753b81257bab0173f4936cb80ce","abstract_canon_sha256":"21c0917e8580cda11d6d9e31e42b54f790698583240d00974ff9fba195011edd"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:24:37.899148Z","signature_b64":"Bznd3uCE5Rw6yqnxoMJGEYuZFRKumtnP1QXBvDKzUJrOQLkF6zm96O+c0uD8UM+6jDyO0PBblmssyadX8uW0Bg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"654caa6e761d140919ca6d04efda482e6a1174885fb4ba0edadc1d8bcab5dcb4","last_reissued_at":"2026-05-18T01:24:37.898657Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:24:37.898657Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Theoretical knock-outs on biological networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Giuliano Gadioli La Guardia, Murilo da Silva Baptista, Pedro Jeferson Miranda, Sandro Ely de Souza Pinto","submitted_at":"2015-12-01T04:01:01Z","abstract_excerpt":"In this work we formalize a method to compute the degree of importance of biological agents that participates on the dynamics of a biological phenomenon build upon a complex network. We call this new procedure by theoretical knock-out (KO). To devise this method, we make two approaches: algebraically and algorithmically. In both cases we compute a vector on an asymptotic state, called flux vector. The flux is given by a random walk on a directed graph that represents a biological phenomenon. This vector gives us the information about the relative flux of walkers on a vertex which represents a "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.03094","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1512.03094","created_at":"2026-05-18T01:24:37.898734+00:00"},{"alias_kind":"arxiv_version","alias_value":"1512.03094v1","created_at":"2026-05-18T01:24:37.898734+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.03094","created_at":"2026-05-18T01:24:37.898734+00:00"},{"alias_kind":"pith_short_12","alias_value":"MVGKU3TWDUKA","created_at":"2026-05-18T12:29:32.376354+00:00"},{"alias_kind":"pith_short_16","alias_value":"MVGKU3TWDUKASGOK","created_at":"2026-05-18T12:29:32.376354+00:00"},{"alias_kind":"pith_short_8","alias_value":"MVGKU3TW","created_at":"2026-05-18T12:29:32.376354+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ","json":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ.json","graph_json":"https://pith.science/api/pith-number/MVGKU3TWDUKASGOKNUCO7WSIFZ/graph.json","events_json":"https://pith.science/api/pith-number/MVGKU3TWDUKASGOKNUCO7WSIFZ/events.json","paper":"https://pith.science/paper/MVGKU3TW"},"agent_actions":{"view_html":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ","download_json":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ.json","view_paper":"https://pith.science/paper/MVGKU3TW","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1512.03094&json=true","fetch_graph":"https://pith.science/api/pith-number/MVGKU3TWDUKASGOKNUCO7WSIFZ/graph.json","fetch_events":"https://pith.science/api/pith-number/MVGKU3TWDUKASGOKNUCO7WSIFZ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ/action/storage_attestation","attest_author":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ/action/author_attestation","sign_citation":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ/action/citation_signature","submit_replication":"https://pith.science/pith/MVGKU3TWDUKASGOKNUCO7WSIFZ/action/replication_record"}},"created_at":"2026-05-18T01:24:37.898734+00:00","updated_at":"2026-05-18T01:24:37.898734+00:00"}