{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:MWMAJTJEA7SQX7TO5FHRYHVVVE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"781c43d08541f4410b0936016926c79d7d564c59a0d019ac8a9da20d92b99361","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2017-06-25T16:19:18Z","title_canon_sha256":"0bfa8756aca1c9eab56960186d579620a01222025c3ede94138e75b1f27a115d"},"schema_version":"1.0","source":{"id":"1706.08836","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1706.08836","created_at":"2026-05-18T00:41:12Z"},{"alias_kind":"arxiv_version","alias_value":"1706.08836v2","created_at":"2026-05-18T00:41:12Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1706.08836","created_at":"2026-05-18T00:41:12Z"},{"alias_kind":"pith_short_12","alias_value":"MWMAJTJEA7SQ","created_at":"2026-05-18T12:31:31Z"},{"alias_kind":"pith_short_16","alias_value":"MWMAJTJEA7SQX7TO","created_at":"2026-05-18T12:31:31Z"},{"alias_kind":"pith_short_8","alias_value":"MWMAJTJE","created_at":"2026-05-18T12:31:31Z"}],"graph_snapshots":[{"event_id":"sha256:5a13908767d1a20bff5c4d3fabd82eec9604d8a67b5089ccf2c6d002c558d3e5","target":"graph","created_at":"2026-05-18T00:41:12Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Characterization of host responses associated with severe malaria through an integrative approach is necessary to understand the dynamics of a \\textit{Plasmodium cynomolgi} infection. In this study, we conducted temporal immune profiling, cytokine profiling and transcriptomic analysis of five \\textit{Macaca mulatta} infected with \\textit{P. cynomolgi}. This experiment resulted in two severe infections, and two mild infections. Our analysis reveals that differential transcriptional up-regulation of genes linked with response to pathogen-associated molecular pattern (PAMP) and pro-inflammatory c","authors_text":"Diego M. Moncada, Elizabeth D. Trippe, Juan B. Gutierrez, Yi H. Yan","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2017-06-25T16:19:18Z","title":"Correlates of severity of disease in Macaca mulatta infected with Plasmodium cynomolgi"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1706.08836","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:412d3f21d0c262bbcd06c11f485973e30cf87937847ff7046933602cf4d15961","target":"record","created_at":"2026-05-18T00:41:12Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"781c43d08541f4410b0936016926c79d7d564c59a0d019ac8a9da20d92b99361","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2017-06-25T16:19:18Z","title_canon_sha256":"0bfa8756aca1c9eab56960186d579620a01222025c3ede94138e75b1f27a115d"},"schema_version":"1.0","source":{"id":"1706.08836","kind":"arxiv","version":2}},"canonical_sha256":"659804cd2407e50bfe6ee94f1c1eb5a91a5860ca9ba9a677a89bb3826c34b5c0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"659804cd2407e50bfe6ee94f1c1eb5a91a5860ca9ba9a677a89bb3826c34b5c0","first_computed_at":"2026-05-18T00:41:12.134814Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:41:12.134814Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"8RkkRKGbEhr8et23iEhwSl30K1AgOB8iIwaPGJEnhVcB/Mk/q6JWu/PE7TdjPu+zJuFanZuh2cj/09lWmc5BDg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:41:12.135486Z","signed_message":"canonical_sha256_bytes"},"source_id":"1706.08836","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:412d3f21d0c262bbcd06c11f485973e30cf87937847ff7046933602cf4d15961","sha256:5a13908767d1a20bff5c4d3fabd82eec9604d8a67b5089ccf2c6d002c558d3e5"],"state_sha256":"db2bbaf83deca4be31f901b9349d4ac66bce845073ffdc7042b20e17e77e4483"}