{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:MXQFQIANXZDI5AVKEYRVB7J6I4","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2006296e328cc944380d6020f7a9f248f2313fb1ca5af29f489b6855389fe0e6","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-03-13T01:53:41Z","title_canon_sha256":"9fd0c1928a0d07d32230fed78e7cc5f812ee78e31c14f488bab8702ce5ea7a02"},"schema_version":"1.0","source":{"id":"1503.03928","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1503.03928","created_at":"2026-05-18T01:07:49Z"},{"alias_kind":"arxiv_version","alias_value":"1503.03928v3","created_at":"2026-05-18T01:07:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.03928","created_at":"2026-05-18T01:07:49Z"},{"alias_kind":"pith_short_12","alias_value":"MXQFQIANXZDI","created_at":"2026-05-18T12:29:32Z"},{"alias_kind":"pith_short_16","alias_value":"MXQFQIANXZDI5AVK","created_at":"2026-05-18T12:29:32Z"},{"alias_kind":"pith_short_8","alias_value":"MXQFQIAN","created_at":"2026-05-18T12:29:32Z"}],"graph_snapshots":[{"event_id":"sha256:cc99e3671ac680d33e043ab65fd191d7f58c4774c2a00a98d259fcc7e89bdc97","target":"graph","created_at":"2026-05-18T01:07:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In bacteria such as $\\textit{Escherichia coli}$, DNA is compacted into a nucleoid near the cell center, while ribosomes$-$molecular complexes that translate messenger RNAs (mRNAs) into proteins$-$are mainly localized at the poles. We study the impact of this spatial organization using a minimal reaction-diffusion model for the cellular transcriptional-translational machinery. Our model predicts that $\\sim 90\\%$ of mRNAs are segregated to the poles and reveals a \"circulation\" of ribosomes driven by the flux of mRNAs, from synthesis in the nucleoid to degradation at the poles. To address the exi","authors_text":"Michele Castellana, Ned S. Wingreen, Sophia Hsin-Jung Li","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-03-13T01:53:41Z","title":"Spatial organization of bacterial transcription and translation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.03928","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:eb377c4fed08bfae7220872552184b4d31e78761bf1f0c72a12ca273179c1b0c","target":"record","created_at":"2026-05-18T01:07:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2006296e328cc944380d6020f7a9f248f2313fb1ca5af29f489b6855389fe0e6","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-03-13T01:53:41Z","title_canon_sha256":"9fd0c1928a0d07d32230fed78e7cc5f812ee78e31c14f488bab8702ce5ea7a02"},"schema_version":"1.0","source":{"id":"1503.03928","kind":"arxiv","version":3}},"canonical_sha256":"65e058200dbe468e82aa262350fd3e47382f523de3ee23cb507678a1e6d8c953","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"65e058200dbe468e82aa262350fd3e47382f523de3ee23cb507678a1e6d8c953","first_computed_at":"2026-05-18T01:07:49.097299Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:07:49.097299Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"xNZrkxWedqbNBx14AfZeq9B1QuystK6hS0NIUV+ZcG6BE8KLaV1owz1NY4REsU+VnAXVFoYZcRmjvYeY7gX+Dw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:07:49.097878Z","signed_message":"canonical_sha256_bytes"},"source_id":"1503.03928","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:eb377c4fed08bfae7220872552184b4d31e78761bf1f0c72a12ca273179c1b0c","sha256:cc99e3671ac680d33e043ab65fd191d7f58c4774c2a00a98d259fcc7e89bdc97"],"state_sha256":"394399d0139a8c9297017cdd209a71da99900887b279ee1fb28d6041a24c85d4"}