{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:MXVAYN62YZ3PIOMA43ETEKEXJC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d2205dcf0970bf12b5f8708c66ae4fbec3b78632c987f609cdf10ccf20a592a4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2009-02-17T13:02:42Z","title_canon_sha256":"114396b2a65dfd18c803ee6ebb333e16487ef8f8e8515c0fca005f9e4cf27b53"},"schema_version":"1.0","source":{"id":"0902.2918","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0902.2918","created_at":"2026-05-18T02:14:47Z"},{"alias_kind":"arxiv_version","alias_value":"0902.2918v1","created_at":"2026-05-18T02:14:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0902.2918","created_at":"2026-05-18T02:14:47Z"},{"alias_kind":"pith_short_12","alias_value":"MXVAYN62YZ3P","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_16","alias_value":"MXVAYN62YZ3PIOMA","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_8","alias_value":"MXVAYN62","created_at":"2026-05-18T12:26:00Z"}],"graph_snapshots":[{"event_id":"sha256:ca643a5d1a0c29e61794ebfa7a5ed68be99568f4fdfc44b7133fd4b795531b07","target":"graph","created_at":"2026-05-18T02:14:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Regulatory interactions between genes show a large amount of cross-species variability, even when the underlying functions are conserved: There are many ways to achieve the same function. Here we investigate the ability of regulatory networks to reproduce given expression levels within a simple model of gene regulation. We find an exponentially large space of regulatory networks compatible with a given set of expression levels, giving rise to an extensive entropy of networks. Typical realisations of regulatory networks are found to share a bias towards symmetric interactions, in line with empi","authors_text":"Franck Stauffer, Johannes Berg","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2009-02-17T13:02:42Z","title":"Adaptive gene regulatory networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0902.2918","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b4b983f37b9b2f01b431c7ad363bf221b15708bbfae77584b5fbe839e330bec1","target":"record","created_at":"2026-05-18T02:14:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d2205dcf0970bf12b5f8708c66ae4fbec3b78632c987f609cdf10ccf20a592a4","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2009-02-17T13:02:42Z","title_canon_sha256":"114396b2a65dfd18c803ee6ebb333e16487ef8f8e8515c0fca005f9e4cf27b53"},"schema_version":"1.0","source":{"id":"0902.2918","kind":"arxiv","version":1}},"canonical_sha256":"65ea0c37dac676f43980e6c932289748b784905e2c7d2f3b61354363a88c6c28","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"65ea0c37dac676f43980e6c932289748b784905e2c7d2f3b61354363a88c6c28","first_computed_at":"2026-05-18T02:14:47.358577Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:14:47.358577Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"vdXJp6e99dwvwaRzAYCL+25zEMpddQZC1hWCge1Hzy3Y0Xj6YaXisvWevmDY59dSUoU9WI6kD49hpgVZVoDsBA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:14:47.359119Z","signed_message":"canonical_sha256_bytes"},"source_id":"0902.2918","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b4b983f37b9b2f01b431c7ad363bf221b15708bbfae77584b5fbe839e330bec1","sha256:ca643a5d1a0c29e61794ebfa7a5ed68be99568f4fdfc44b7133fd4b795531b07"],"state_sha256":"661de682601c432e80e44a43064c723186e562fea5a88b1c91a8e3e9345b5761"}