{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2018:N47ZTDSWHCWIF25KRTHTB45NOV","short_pith_number":"pith:N47ZTDSW","schema_version":"1.0","canonical_sha256":"6f3f998e5638ac82ebaa8ccf30f3ad757b8208291527a016d91f5ad6bec0799a","source":{"kind":"arxiv","id":"1806.08649","version":1},"attestation_state":"computed","paper":{"title":"The clinical target distribution: a probabilistic alternative to the clinical target volume","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"David Craft, Helen Shih, Nadya Shusharina, Thomas Bortfeld, Yen-Lin Chen","submitted_at":"2018-06-22T13:20:42Z","abstract_excerpt":"Definition of the clinical target volume (CTV) is one of the weakest links in the radiation therapy chain. In particular, inability to account for uncertainties is a severe limitation in the traditional CTV delineation approach. Here, we introduce and test a new concept for tumor target definition, the clinical target distribution (CTD). The CTD is a continuous distribution of the probability of voxels to be tumorous. We describe an approach to incorporate the CTD in treatment plan optimization algorithms, and implement it in a commercial treatment planning system. We test the approach in two "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1806.08649","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2018-06-22T13:20:42Z","cross_cats_sorted":[],"title_canon_sha256":"45d326359c053e71b2303099800923d34fae61af51a413718c21b4fb921039d3","abstract_canon_sha256":"759d1d77eecc3ca8dd553201d1b48b5bde3aedde1081e55d60754526824682c1"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:08:06.296424Z","signature_b64":"yjo+aQbudH5ABPj47bYQgjmNgCt5H9zSxxoDeMEvnmOPHPSZMpqWO7W9ERYDNNiLvGM+lFs5FTVx4PMNDZxTDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6f3f998e5638ac82ebaa8ccf30f3ad757b8208291527a016d91f5ad6bec0799a","last_reissued_at":"2026-05-18T00:08:06.295972Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:08:06.295972Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"The clinical target distribution: a probabilistic alternative to the clinical target volume","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"David Craft, Helen Shih, Nadya Shusharina, Thomas Bortfeld, Yen-Lin Chen","submitted_at":"2018-06-22T13:20:42Z","abstract_excerpt":"Definition of the clinical target volume (CTV) is one of the weakest links in the radiation therapy chain. In particular, inability to account for uncertainties is a severe limitation in the traditional CTV delineation approach. Here, we introduce and test a new concept for tumor target definition, the clinical target distribution (CTD). The CTD is a continuous distribution of the probability of voxels to be tumorous. We describe an approach to incorporate the CTD in treatment plan optimization algorithms, and implement it in a commercial treatment planning system. We test the approach in two "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1806.08649","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1806.08649","created_at":"2026-05-18T00:08:06.296040+00:00"},{"alias_kind":"arxiv_version","alias_value":"1806.08649v1","created_at":"2026-05-18T00:08:06.296040+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1806.08649","created_at":"2026-05-18T00:08:06.296040+00:00"},{"alias_kind":"pith_short_12","alias_value":"N47ZTDSWHCWI","created_at":"2026-05-18T12:32:40.477152+00:00"},{"alias_kind":"pith_short_16","alias_value":"N47ZTDSWHCWIF25K","created_at":"2026-05-18T12:32:40.477152+00:00"},{"alias_kind":"pith_short_8","alias_value":"N47ZTDSW","created_at":"2026-05-18T12:32:40.477152+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV","json":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV.json","graph_json":"https://pith.science/api/pith-number/N47ZTDSWHCWIF25KRTHTB45NOV/graph.json","events_json":"https://pith.science/api/pith-number/N47ZTDSWHCWIF25KRTHTB45NOV/events.json","paper":"https://pith.science/paper/N47ZTDSW"},"agent_actions":{"view_html":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV","download_json":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV.json","view_paper":"https://pith.science/paper/N47ZTDSW","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1806.08649&json=true","fetch_graph":"https://pith.science/api/pith-number/N47ZTDSWHCWIF25KRTHTB45NOV/graph.json","fetch_events":"https://pith.science/api/pith-number/N47ZTDSWHCWIF25KRTHTB45NOV/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV/action/timestamp_anchor","attest_storage":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV/action/storage_attestation","attest_author":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV/action/author_attestation","sign_citation":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV/action/citation_signature","submit_replication":"https://pith.science/pith/N47ZTDSWHCWIF25KRTHTB45NOV/action/replication_record"}},"created_at":"2026-05-18T00:08:06.296040+00:00","updated_at":"2026-05-18T00:08:06.296040+00:00"}