{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2012:N4MEHB6XO4DXBXJQIPU5LX7GU6","short_pith_number":"pith:N4MEHB6X","schema_version":"1.0","canonical_sha256":"6f184387d7770770dd3043e9d5dfe6a7a820d9007d47eaf89e623e69c8dc81a8","source":{"kind":"arxiv","id":"1210.7006","version":1},"attestation_state":"computed","paper":{"title":"A Multi-Criteria Framework with Voxel-Dependent Parameters for Radiotherapy Treatment Plan Optimization","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Andres F. Uribe-Sanchez, Masoud Zarepisheh, Nan Li, Steve B. Jiang, Xun Jia","submitted_at":"2012-10-25T22:03:14Z","abstract_excerpt":"In a treatment plan optimization problem for radiotherapy, a clinically acceptable plan is usually generated by an optimization process with weighting factors or reference doses adjusted for organs. Recent discoveries indicate that adjusting parameters associated with each voxel may lead to better plan quality. However, it is still unclear regarding the mathematical reasons behind it. To answer questions related to this problem, we establish in this work a new mathematical framework equipped with two theorems. The new framework clarifies the different consequences of adjusting organ-dependent "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1210.7006","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2012-10-25T22:03:14Z","cross_cats_sorted":[],"title_canon_sha256":"42df61248062587e9a8e1ae5d30ee539ef86dff767edca3e8f9900dae408c15e","abstract_canon_sha256":"f2ffce38d339c046cf68b2e0c113b04498cbb9994dfc2f2afcf1c894c90cdca8"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:42:22.056232Z","signature_b64":"mCCa2j52Wvhu3iz1FdSEcA0MZ3/aOMKWioVdQYKv1oUdBjLE14Myd220kWm/+eUlZrOmbbZXdvw1FwSSxZ7OBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6f184387d7770770dd3043e9d5dfe6a7a820d9007d47eaf89e623e69c8dc81a8","last_reissued_at":"2026-05-18T03:42:22.055239Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:42:22.055239Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"A Multi-Criteria Framework with Voxel-Dependent Parameters for Radiotherapy Treatment Plan Optimization","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Andres F. Uribe-Sanchez, Masoud Zarepisheh, Nan Li, Steve B. Jiang, Xun Jia","submitted_at":"2012-10-25T22:03:14Z","abstract_excerpt":"In a treatment plan optimization problem for radiotherapy, a clinically acceptable plan is usually generated by an optimization process with weighting factors or reference doses adjusted for organs. Recent discoveries indicate that adjusting parameters associated with each voxel may lead to better plan quality. However, it is still unclear regarding the mathematical reasons behind it. To answer questions related to this problem, we establish in this work a new mathematical framework equipped with two theorems. The new framework clarifies the different consequences of adjusting organ-dependent "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1210.7006","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1210.7006","created_at":"2026-05-18T03:42:22.055377+00:00"},{"alias_kind":"arxiv_version","alias_value":"1210.7006v1","created_at":"2026-05-18T03:42:22.055377+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1210.7006","created_at":"2026-05-18T03:42:22.055377+00:00"},{"alias_kind":"pith_short_12","alias_value":"N4MEHB6XO4DX","created_at":"2026-05-18T12:27:16.716162+00:00"},{"alias_kind":"pith_short_16","alias_value":"N4MEHB6XO4DXBXJQ","created_at":"2026-05-18T12:27:16.716162+00:00"},{"alias_kind":"pith_short_8","alias_value":"N4MEHB6X","created_at":"2026-05-18T12:27:16.716162+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6","json":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6.json","graph_json":"https://pith.science/api/pith-number/N4MEHB6XO4DXBXJQIPU5LX7GU6/graph.json","events_json":"https://pith.science/api/pith-number/N4MEHB6XO4DXBXJQIPU5LX7GU6/events.json","paper":"https://pith.science/paper/N4MEHB6X"},"agent_actions":{"view_html":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6","download_json":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6.json","view_paper":"https://pith.science/paper/N4MEHB6X","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1210.7006&json=true","fetch_graph":"https://pith.science/api/pith-number/N4MEHB6XO4DXBXJQIPU5LX7GU6/graph.json","fetch_events":"https://pith.science/api/pith-number/N4MEHB6XO4DXBXJQIPU5LX7GU6/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6/action/timestamp_anchor","attest_storage":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6/action/storage_attestation","attest_author":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6/action/author_attestation","sign_citation":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6/action/citation_signature","submit_replication":"https://pith.science/pith/N4MEHB6XO4DXBXJQIPU5LX7GU6/action/replication_record"}},"created_at":"2026-05-18T03:42:22.055377+00:00","updated_at":"2026-05-18T03:42:22.055377+00:00"}