{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:N7BI6TPAIXZAGP3GCG4WESKXNX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"3967ad82ec917ff4636db640ff036c6c6dec8f7f7b2286b0b9ec71884019ae05","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2025-08-06T08:52:03Z","title_canon_sha256":"7e310b464a9599cd71fd6bb1b361eae9a492564e6d6cb6205cc4073edfe24280"},"schema_version":"1.0","source":{"id":"2508.04749","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.04749","created_at":"2026-07-05T11:50:01Z"},{"alias_kind":"arxiv_version","alias_value":"2508.04749v1","created_at":"2026-07-05T11:50:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.04749","created_at":"2026-07-05T11:50:01Z"},{"alias_kind":"pith_short_12","alias_value":"N7BI6TPAIXZA","created_at":"2026-07-05T11:50:01Z"},{"alias_kind":"pith_short_16","alias_value":"N7BI6TPAIXZAGP3G","created_at":"2026-07-05T11:50:01Z"},{"alias_kind":"pith_short_8","alias_value":"N7BI6TPA","created_at":"2026-07-05T11:50:01Z"}],"graph_snapshots":[{"event_id":"sha256:00f069844a92ec743e76c8d4ce5ea3c22643e1b393fda427b71d0b4a897ac90e","target":"graph","created_at":"2026-07-05T11:50:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2508.04749/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The striking alignment between large language models (LLMs) and human brain activity positions them as powerful models of healthy cognition. This parallel raises a fundamental question: if LLMs can model the intact brain, can we lesion them to simulate the linguistic deficits of the injured brain? In this work, we introduce a methodology to model aphasia - a complex language disorder caused by neural injury - by selectively disabling components in a modular Mixture-of-Experts (MoE) language model. We simulate distinct aphasia subtypes, validate their linguistic outputs against real patient spe","authors_text":"Chengqing Zong, Chunyu Ye, Jichen Zheng, Jingyuan Sun, Jixing Li, Shaonan Wang, Yifan Wang, Yunhao Zhang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2025-08-06T08:52:03Z","title":"Bridging Brains and Models: MoE-Based Functional Lesions for Simulating and Rehabilitating Aphasia"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.04749","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4649f366716ad2e7a917a7bf6a4e50e018301c6e5279344f79a3bc4993bd542f","target":"record","created_at":"2026-07-05T11:50:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"3967ad82ec917ff4636db640ff036c6c6dec8f7f7b2286b0b9ec71884019ae05","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2025-08-06T08:52:03Z","title_canon_sha256":"7e310b464a9599cd71fd6bb1b361eae9a492564e6d6cb6205cc4073edfe24280"},"schema_version":"1.0","source":{"id":"2508.04749","kind":"arxiv","version":1}},"canonical_sha256":"6fc28f4de045f2033f6611b96249576dce651b77a0b5e44ba906558e6e359e58","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6fc28f4de045f2033f6611b96249576dce651b77a0b5e44ba906558e6e359e58","first_computed_at":"2026-07-05T11:50:01.134278Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:50:01.134278Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"u4KLr2+7wIhhhdqGfHmSWhrbNzexvTSFtbaTVq7JGmJheNPkXSAV6RtcpK5UxvsojBk5FTPQOfFDk2egkU9cCw==","signature_status":"signed_v1","signed_at":"2026-07-05T11:50:01.134725Z","signed_message":"canonical_sha256_bytes"},"source_id":"2508.04749","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4649f366716ad2e7a917a7bf6a4e50e018301c6e5279344f79a3bc4993bd542f","sha256:00f069844a92ec743e76c8d4ce5ea3c22643e1b393fda427b71d0b4a897ac90e"],"state_sha256":"fbf85b9d6224e31ad41e13082f71cdcedbf8f4934b1c01e539f0296a4332e71e"}