{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:NAMHLL3LWYBHYHWISEA7OGBOPX","short_pith_number":"pith:NAMHLL3L","canonical_record":{"source":{"id":"2211.07398","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-11-11T15:23:09Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"c434aa745ea314bd608c3d67243ee6e4851bc541d3039943df05f422e84a4533","abstract_canon_sha256":"135dcaffd2dd5ae7329c444c6eec2f6bc4c757d7418fa39c6c96572f9d216926"},"schema_version":"1.0"},"canonical_sha256":"681875af6bb6027c1ec89101f7182e7ddfd1aceef3017e43f783af2cd076537b","source":{"kind":"arxiv","id":"2211.07398","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2211.07398","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"arxiv_version","alias_value":"2211.07398v2","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2211.07398","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"pith_short_12","alias_value":"NAMHLL3LWYBH","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"pith_short_16","alias_value":"NAMHLL3LWYBHYHWI","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"pith_short_8","alias_value":"NAMHLL3L","created_at":"2026-07-05T06:27:43Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:NAMHLL3LWYBHYHWISEA7OGBOPX","target":"record","payload":{"canonical_record":{"source":{"id":"2211.07398","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-11-11T15:23:09Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"c434aa745ea314bd608c3d67243ee6e4851bc541d3039943df05f422e84a4533","abstract_canon_sha256":"135dcaffd2dd5ae7329c444c6eec2f6bc4c757d7418fa39c6c96572f9d216926"},"schema_version":"1.0"},"canonical_sha256":"681875af6bb6027c1ec89101f7182e7ddfd1aceef3017e43f783af2cd076537b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T06:27:43.526413Z","signature_b64":"xbRri5C10zzwOeQVMuSsmJGCGjlrqCWcQPRxyoxzh5cSE3Fyi0vthIRlgkSmLOcbMepOYP70wN19HJv+cm3xBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"681875af6bb6027c1ec89101f7182e7ddfd1aceef3017e43f783af2cd076537b","last_reissued_at":"2026-07-05T06:27:43.525923Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T06:27:43.525923Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2211.07398","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T06:27:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"oeohveB/DHuhMFNkA/Bpi0adzK/YyHwtgy8wp1BPAlAnwNwtkVFOCU40UGY9eW1zd9ftSuUAKza3EiSd8NLkAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-18T23:48:44.337040Z"},"content_sha256":"a8991bfafcc202884e9b9a0c78196e91157afad01c9537e48e3a8472cbe51f0c","schema_version":"1.0","event_id":"sha256:a8991bfafcc202884e9b9a0c78196e91157afad01c9537e48e3a8472cbe51f0c"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:NAMHLL3LWYBHYHWISEA7OGBOPX","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Age Prediction Performance Varies Across Deep, Superficial, and Cerebellar White Matter Connections","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.LG"],"primary_cat":"q-bio.NC","authors_text":"Fan Zhang, Lauren J. O'Donnell, Nikos Makris, Tengfei Xue, Yogesh Rathi, Yuxiang Wei","submitted_at":"2022-11-11T15:23:09Z","abstract_excerpt":"The brain's white matter (WM) undergoes developmental and degenerative processes during the human lifespan. To investigate the relationship between WM anatomical regions and age, we study diffusion magnetic resonance imaging tractography that is finely parcellated into fiber clusters in the deep, superficial, and cerebellar WM. We propose a deep-learning-based age prediction model that leverages large convolutional kernels and inverted bottlenecks. We improve performance using novel discrete multi-faceted mix data augmentation and a novel prior-knowledge-based loss function that encourages age"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2211.07398","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2211.07398/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T06:27:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"zM7Bzs2mfS1+CmK/3htOIaW+3utNsJwemLFdXR0Ejvgcm4rH4ObjvL+rcIZgA81LLbvHMPzVk7Y/cKh7VO6xCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-18T23:48:44.337911Z"},"content_sha256":"21c7597a5816adf69768ec035f7fbe3dcef66ff6caeb8e53b82629ed53d4adc1","schema_version":"1.0","event_id":"sha256:21c7597a5816adf69768ec035f7fbe3dcef66ff6caeb8e53b82629ed53d4adc1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/NAMHLL3LWYBHYHWISEA7OGBOPX/bundle.json","state_url":"https://pith.science/pith/NAMHLL3LWYBHYHWISEA7OGBOPX/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/NAMHLL3LWYBHYHWISEA7OGBOPX/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-18T23:48:44Z","links":{"resolver":"https://pith.science/pith/NAMHLL3LWYBHYHWISEA7OGBOPX","bundle":"https://pith.science/pith/NAMHLL3LWYBHYHWISEA7OGBOPX/bundle.json","state":"https://pith.science/pith/NAMHLL3LWYBHYHWISEA7OGBOPX/state.json","well_known_bundle":"https://pith.science/.well-known/pith/NAMHLL3LWYBHYHWISEA7OGBOPX/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:NAMHLL3LWYBHYHWISEA7OGBOPX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"135dcaffd2dd5ae7329c444c6eec2f6bc4c757d7418fa39c6c96572f9d216926","cross_cats_sorted":["cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-11-11T15:23:09Z","title_canon_sha256":"c434aa745ea314bd608c3d67243ee6e4851bc541d3039943df05f422e84a4533"},"schema_version":"1.0","source":{"id":"2211.07398","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2211.07398","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"arxiv_version","alias_value":"2211.07398v2","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2211.07398","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"pith_short_12","alias_value":"NAMHLL3LWYBH","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"pith_short_16","alias_value":"NAMHLL3LWYBHYHWI","created_at":"2026-07-05T06:27:43Z"},{"alias_kind":"pith_short_8","alias_value":"NAMHLL3L","created_at":"2026-07-05T06:27:43Z"}],"graph_snapshots":[{"event_id":"sha256:21c7597a5816adf69768ec035f7fbe3dcef66ff6caeb8e53b82629ed53d4adc1","target":"graph","created_at":"2026-07-05T06:27:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2211.07398/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The brain's white matter (WM) undergoes developmental and degenerative processes during the human lifespan. To investigate the relationship between WM anatomical regions and age, we study diffusion magnetic resonance imaging tractography that is finely parcellated into fiber clusters in the deep, superficial, and cerebellar WM. We propose a deep-learning-based age prediction model that leverages large convolutional kernels and inverted bottlenecks. We improve performance using novel discrete multi-faceted mix data augmentation and a novel prior-knowledge-based loss function that encourages age","authors_text":"Fan Zhang, Lauren J. O'Donnell, Nikos Makris, Tengfei Xue, Yogesh Rathi, Yuxiang Wei","cross_cats":["cs.LG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-11-11T15:23:09Z","title":"Age Prediction Performance Varies Across Deep, Superficial, and Cerebellar White Matter Connections"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2211.07398","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a8991bfafcc202884e9b9a0c78196e91157afad01c9537e48e3a8472cbe51f0c","target":"record","created_at":"2026-07-05T06:27:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"135dcaffd2dd5ae7329c444c6eec2f6bc4c757d7418fa39c6c96572f9d216926","cross_cats_sorted":["cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2022-11-11T15:23:09Z","title_canon_sha256":"c434aa745ea314bd608c3d67243ee6e4851bc541d3039943df05f422e84a4533"},"schema_version":"1.0","source":{"id":"2211.07398","kind":"arxiv","version":2}},"canonical_sha256":"681875af6bb6027c1ec89101f7182e7ddfd1aceef3017e43f783af2cd076537b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"681875af6bb6027c1ec89101f7182e7ddfd1aceef3017e43f783af2cd076537b","first_computed_at":"2026-07-05T06:27:43.525923Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T06:27:43.525923Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"xbRri5C10zzwOeQVMuSsmJGCGjlrqCWcQPRxyoxzh5cSE3Fyi0vthIRlgkSmLOcbMepOYP70wN19HJv+cm3xBA==","signature_status":"signed_v1","signed_at":"2026-07-05T06:27:43.526413Z","signed_message":"canonical_sha256_bytes"},"source_id":"2211.07398","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a8991bfafcc202884e9b9a0c78196e91157afad01c9537e48e3a8472cbe51f0c","sha256:21c7597a5816adf69768ec035f7fbe3dcef66ff6caeb8e53b82629ed53d4adc1"],"state_sha256":"b0611d5802c3514dfaf81a421ab62d51e6db790b550e6e5614f9ffe22da634eb"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"HWJi9wgwfbNkn9b20BjlHV1ni+Sv1ATLsZ/2cnQfLRZpga4p7etbrkbsd7OnAYaz5FDmRk+FC1Cwl6IYHUahAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-18T23:48:44.355209Z","bundle_sha256":"950aea20a86af77f7eda26e0949aa8652b0fe6e534834edcf7d5faa82b8914b3"}}