{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2011:NBO5M6IEQ2MIURREDFJRVR5EJU","short_pith_number":"pith:NBO5M6IE","schema_version":"1.0","canonical_sha256":"685dd6790486988a462419531ac7a44d2e1fcbe1feb0e18f8b514bc4b4fd20e9","source":{"kind":"arxiv","id":"1108.4121","version":2},"attestation_state":"computed","paper":{"title":"Non-equilibrium phase transitions in biomolecular signal transduction","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech"],"primary_cat":"q-bio.SC","authors_text":"David Krakauer, Eric Smith, Supriya Krishnamurthy, Walter Fontana","submitted_at":"2011-08-20T15:36:51Z","abstract_excerpt":"We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of any molecule, by means of which the switch is implemented, are highly stochastic. The emergence of switching is a nonequilibrium phase transition in an energetically driven, dissipative system described by a master equation. We use operator and functional integral methods from reaction-diffusion theory to solve for the phase structure, noise s"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1108.4121","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2011-08-20T15:36:51Z","cross_cats_sorted":["cond-mat.stat-mech"],"title_canon_sha256":"2572cc3f0ac2a5f52a52da61463b12154ce070d7792ef4866b971413da202af9","abstract_canon_sha256":"f9355045cb6977be05a647437252a62944ba0ac674273b00a3e8b0d97daec64a"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:00:50.165103Z","signature_b64":"CSwGDo51z+zWLYDTiY1kIO4d8MFpEyOQ0EkW6YMYFJgXETFitTeWx/NvGmnIK1ldPwjTG6SA0ovtw+/UoGKYDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"685dd6790486988a462419531ac7a44d2e1fcbe1feb0e18f8b514bc4b4fd20e9","last_reissued_at":"2026-05-18T02:00:50.164654Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:00:50.164654Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Non-equilibrium phase transitions in biomolecular signal transduction","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech"],"primary_cat":"q-bio.SC","authors_text":"David Krakauer, Eric Smith, Supriya Krishnamurthy, Walter Fontana","submitted_at":"2011-08-20T15:36:51Z","abstract_excerpt":"We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of any molecule, by means of which the switch is implemented, are highly stochastic. The emergence of switching is a nonequilibrium phase transition in an energetically driven, dissipative system described by a master equation. We use operator and functional integral methods from reaction-diffusion theory to solve for the phase structure, noise s"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1108.4121","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1108.4121","created_at":"2026-05-18T02:00:50.164726+00:00"},{"alias_kind":"arxiv_version","alias_value":"1108.4121v2","created_at":"2026-05-18T02:00:50.164726+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1108.4121","created_at":"2026-05-18T02:00:50.164726+00:00"},{"alias_kind":"pith_short_12","alias_value":"NBO5M6IEQ2MI","created_at":"2026-05-18T12:26:37.096874+00:00"},{"alias_kind":"pith_short_16","alias_value":"NBO5M6IEQ2MIURRE","created_at":"2026-05-18T12:26:37.096874+00:00"},{"alias_kind":"pith_short_8","alias_value":"NBO5M6IE","created_at":"2026-05-18T12:26:37.096874+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU","json":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU.json","graph_json":"https://pith.science/api/pith-number/NBO5M6IEQ2MIURREDFJRVR5EJU/graph.json","events_json":"https://pith.science/api/pith-number/NBO5M6IEQ2MIURREDFJRVR5EJU/events.json","paper":"https://pith.science/paper/NBO5M6IE"},"agent_actions":{"view_html":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU","download_json":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU.json","view_paper":"https://pith.science/paper/NBO5M6IE","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1108.4121&json=true","fetch_graph":"https://pith.science/api/pith-number/NBO5M6IEQ2MIURREDFJRVR5EJU/graph.json","fetch_events":"https://pith.science/api/pith-number/NBO5M6IEQ2MIURREDFJRVR5EJU/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU/action/timestamp_anchor","attest_storage":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU/action/storage_attestation","attest_author":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU/action/author_attestation","sign_citation":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU/action/citation_signature","submit_replication":"https://pith.science/pith/NBO5M6IEQ2MIURREDFJRVR5EJU/action/replication_record"}},"created_at":"2026-05-18T02:00:50.164726+00:00","updated_at":"2026-05-18T02:00:50.164726+00:00"}